Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis

(1)

Title

Enhanced dendritic cells and regulatory T cells in the dermis of

_{porokeratosis( 要約版(Digest) )}

Author(s)

松山, かなこ

Report No.(Doctoral

Degree)

博士(医学) 甲第1087号

Issue Date

2018-09-12

Type

博士論文

Version

none

URL

http://hdl.handle.net/20.500.12099/77233

※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。

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࣏ࣜࢪࢺࣜ㛵ಀ㸦ู⣬㸲㸧

Repository㸦Form4㸧

Ꮫ఩ㄽᩥせ⣙

Extended Summary in Lieu of the Full Text of a Doctoral Thesis

Ặ ྡ㸸

Full Name

ᯇᒣ࠿࡞ࡇ

Kanako Matsuyama

Ꮫ఩ㄽᩥ㢟┠㸸

Thesis Title (QKDQFHGGHQGULWLFFHOOVDQGUHJXODWRU\7FHOOVLQWKHGHUPLVRI SRURNHUDWRVLV

Ꮫ఩ㄽᩥせ⣙㸸

Summary of Thesis ờᏍゅ໬⑕㸦SRURNHUDWRVLVࡣࠊ⮫ᗋⓗ࡟ࡣ㎶⦕ࡀሐ㜵≧࡟㝯㉳ࡋ୰ᚰ㒊ࡀⴎ⦰ᛶ࡛ࠊ㐲ᚰᛶ࡟ᣑ኱ࡍࡿ⡿ ⢏኱࠿ࡽᡭᣙ኱⛬ᗘࡲ࡛ࡢゅ໬ᛶ⎔≧⓶⑈ࢆ࿊ࡋࠊ⑓⌮Ꮫⓗ࡟ࡣ㎶⦕㒊࡟୍⮴ࡋ࡚ゅ໬෇ᰕ㸦 FRUQRLG ODPHOODࢆᣢࡘ≉ᚩࡀ࠶ࡿࠋᮏ⑌ᝈࡢ≉ᚩ࡛࠶ࡿ FRUQRLGODPHOOD ࡣ␗ᆺ⾲⓶ゅ໬⣽⬊ࡢࢡ࣮ࣟࣥࡀቑṪࡋ ⏕ࡌࡓ⌧㇟࡛࠶ࡿ࡜⪃࠼ࡽࢀࠊࡇࡢ⣽⬊ࡣ⣸እ⥺ࡸࠊእയࠊ+,9 ࡸ & ᆺ⫢⅖࢘࢖ࣝࢫឤᰁࠊච␿ᢚไ≧ែ࡞ ࡝ࡀዎᶵ࡜࡞ࡾቑṪࡍࡿ࡜ሗ࿌ࡉࢀ࡚࠸ࡿࠋ ≉࡟ࠊ⣸እ⥺ࡣ⓶⭵ࡢᒁᡤච␿⬟ࢆపୗࡉࡏࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊờᏍゅ໬⑕ࡢⓎ⑕࡟࠾ࡅࡿච␿ࡢ㔜せᛶࡀ᥎ ࡉࢀࡿࡀⓎ⑕⑓ᅉࡣᮍࡔ୙࡛᫂࠶ࡿࠋࢃࢀࢃࢀࡣࠊSRURNHUDWRVLV ࡢ⑓ᅉ࣭⑓ែࢆ᥈ࡿࡓࡵච␿ ⤌⧊Ꮫⓗ᳨ウࢆ⾜ࡗࡓࠋ ࠙ᑐ㇟࡜᪉ἲࠚ ᙜ㝔ࡢ་Ꮫ◊✲➼೔⌮ᑂᰝጤဨ఍ࡢᢎㄆࢆᚓ࡚ࠊ ᖺ࠿ࡽ ᖺࡲ࡛࡟ᙜ⛉࡛ờᏍゅ໬⑕࡜デ᩿ࡉࢀࡓ ⑕౛ࢆ᳨ウࡋࡓࠋ⑓ᆺࡢ࠺ࡕࢃࡅࡣྂ඾ᆺ㸦0LEHOL ᆺ㸧 ౛ࠊ᪥ග⾲ᅾ᧛✀ᆺ㸦'6$3 ౛ࠊ⾲ᅾ᧛✀ᆺ 㸦'63 ౛ࠊ⫠㛛࿘ᅖ࡟Ⓨ⑕ࡍࡿ 33 ᆺ ౛࡛࠶ࡗࡓࠋࡍ࡛࡟⮫ᗋⓗཬࡧ⑓⌮Ꮫⓗ࡟☜ᐃデ᩿ࡀࡉࢀࠊ࣍ࣝ ࣐ࣜࣥᅛᐃࡉࢀࡓ⑓⌮᳨యࢆ⏝࠸࡚ࠊච␿ᰁⰍࢆ⾜ࡗࡓࠋච␿⤌⧊໬ᏛᰁⰍࡢ᪉ἲࡣ /6$% ἲࢆ⏝࠸ࠊⓎⰍ࡟ ࡣ '$% ࢆ⏝࠸ࡓࠋ ᰁⰍࡋࡓᶆᮏࡢ᳨ウ᪉ἲࡣࠊ⾲⓶ࢆ ࠿ᡤ࡟㸦ձFRUQRLGODPHOOD&/ 㒊ࠊղ⑓ኚእഃࡢṇᖖ㒊ࢆ WKHDGMDFHQW QRUPDOVNLQ$16 㒊ࠊճ⑓ኚෆ㒊ࢆ WKHLQQHUSDUWRIWKHDQQXODUULGJH,& 㒊࡜༊ศࡋࠊ⾲⓶┤ୗࡢ ┿⓶ὸᒙࡶࠊ⾲⓶ྠᵝࡢ ࠿ᡤ࡟༊ศࡋࠊࡑࡢ୰࠿ࡽ ࠿ᡤࢆ↓సⅭ࡟㑅ࡧࠊ᳨ウࡍࡿ㡿ᇦࢆỴᐃࡋࡓࠋ᳨ ウࡋࡓᶆᮏࡢ㠃✚ࡢ ᐃࡢࡓࡵ࡟ %=ϩࢯࣇࢺࢆ฼⏝ࡋࡓࠋ3ࢆ᭷ព࡜ุᐃࡋࡓࠋ ࠙⤖ᯝࠚ ⾲⓶ゅ໬⣽⬊࡟༨ࡵࡿ .L 㝧ᛶ⣽⬊ࡢ๭ྜࡣࠊFRUQRLGODPHOOD 㒊࡛᭷ព࡟ቑຍࡋ࡚࠸ࡓ㸦3㸺㸧ࠋᢠ &'D ᢠయᰁⰍ࡛ࡣ⾲⓶ෆࡢ &'D 㝧ᛶ⣽⬊ᐦᗘࡣ FRUQRLGODPHOOD ࡜ࠊSRURNHUDWRVLV ࡢ⑓ኚෆ࡛᭷ព࡟ῶᑡ

ࡋ࡚࠾ࡾ㸦3㸧ࠊ୍᪉ࠊ┿⓶ෆ࡛ࡣቑຍࡋ࡚࠸ࡓ3ࠋ

ḟ࡟┿⓶࡬ᾐ₶ࡋ࡚࠸ࡿ⅖⑕⣽⬊ࢆᢠ &'&'&'&' ᢠయࠊᢠ )2;S ᢠయᰁⰍᶆᮏ࡛ホ౯ࡋࡓࠋᢠ &'&'&' ᢠయࠊᢠ )2;S ᢠయ㝧ᛶ⣽⬊ࡣ &/ 㒊࡛ቑຍࡋ࡚࠸ࡓࡀ⤫ィⓗ᭷ព࠿࡝࠺࠿ࡶ࡞ࡃᢠ &' ᢠయ 㝧ᛶ⣽⬊ࡣぢࡽࢀ࡞࠿ࡗࡓࠋ ࡘ࡙࠸࡚ &' 㝧ᛶ⣽⬊ᩘ࡜ࠊ)R[S 㝧ᛶ⣽⬊ᩘࡢẚ⋡ࢆ᳨ウࡋࡓ࡜ࡇࢁࠊ&/ 㒊࡛ࡣ᭷ព࡟ )R[S 㝧ᛶ⣽⬊ࡢ ༨ࡵࡿ๭ྜࡀቑຍࡋ࡚࠸ࡓࡀࠊ&' 㝧ᛶ⣽⬊࡜ࠊ&' 㝧ᛶ⣽⬊ᩘࡢ๭ྜ࡟ᕪࡣ↓࠿ࡗࡓࠋ ࢃࢀࢃࢀࡣ⾲⓶ෆࡢ &'D 㝧ᛶ⣽⬊ࠊࡍ࡞ࢃࡕ /DQJHUKDQV ⣽⬊ࡢῶᑡ࡜┿⓶ෆࡢไᚚᛶ 7 ⣽⬊ࡢቑຍ࡟ὀ┠ ࡋࡓࠋ㏆ᖺࠊWKHUHFHSWRUDFWLYDWRURIQXFOHDUIDFWRUN%5$1.5$1.OLJDQG5$1./࡟㛵ࡋ࡚ࠊ⾲⓶ゅ ໬⣽⬊ࡢ 5$1./ ࡢ RYHUH[SUHVVLRQ ࡀࠊ⾲⓶ࡢᶞ≧⣽⬊ࡢᶵ⬟ࢆኚ໬ࡉࡏไᚚᛶ 7 ⣽⬊ࢆቑຍࡉࡏࡿ࡜ࡢሗ࿌ ࡸࠊ⣸እ⥺ࡣ≉࡟ 5$1./ ࡢⓎ⌧ࢆᙉࡃㄏᑟࡍࡿᅉᏊ࡛࠶ࡿ࡜ࡢሗ࿌ࡀ࠶ࡿࠋࡇࢀࡽࡢሗ࿌ࢆࡶ࡜࡟ࠊ5$1./ ࡟ࡼࡿච␿ᰁⰍࢆ⾜ࡗࡓ࡜ࡇࢁ FRUQRLG ODPHOOD 㒊ࡢ⾲⓶ゅ໬⣽⬊࡟ᰁⰍࢆ☜ㄆࡋࠊ5$1./ ࡢⓎ⌧ࡀ࠶ࡿ࡜ ホ౯ࡋࡓࠋ ࠙⪃ᐹࠚ ௨ୖࡢ⤖ᯝ࠿ࡽ SRURNHUDWRVLV ࡢ⑓ᅉ࣭⑓ែ࡟㛵ࡋ࡚ࠊࡲࡎ㑇ఏⓗせᅉࢆྵࡴఱࡽ࠿ࡢཎᅉ࡛⾲⓶ෆ࡟␗ᆺ ⾲⓶ゅ໬⣽⬊ࡀฟ⌧ࡋࠊ⣸እ⥺↷ᑕ࡞࡝ࡢ่⃭࡛⾲⓶ゅ໬⣽⬊ࡀ 5$1./ ࢆⓎ⌧ࡋࠊ⾲⓶ෆ /DQJHUKDQV ⣽⬊ࢆ ่⃭ࡋࠊ7UHJ ࢆㄏᑟࡍࡿࡇ࡜࡛⓶⭵ᒁᡤࡢච␿ᢚไ࡟㛵୚ࡍࡿࠋ ࡑࡢච␿ᢚไ≧ែ࡟ࡼࡾ␗ᆺ⾲⓶ゅ໬⣽⬊ࡀቑṪࡋࠊFRUQRLGODPHOOD ࡀᙧᡂࡉࢀࠊ⑓ኚࡀᣑ኱ࡋ࡚࠸ࡃྍ ⬟ᛶࢆ⪃࠼ࡓࠋ

Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis

Title