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IRUCAA@TDC : A new feedback loop for spatial patterning of the teeth

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Posted at the Institutional Resources for Unique Collection and Academic Archives at Tokyo Dental College, Available from http://ir.tdc.ac.jp/

Title

A new feedback loop for spatial patterning of the

teeth

Author(s)

Han-Sung, Jung

Journal

歯科学報, 111(4): 417-417

URL

http://hdl.handle.net/10130/2591

(2)

Each vertebrate species displays specific tooth patterns in each quadrant of the jaw : the mouse has one in-cisor and three molars, which develop at precise locations and at different times. The reason why multiple teeth form in the jaw of vertebrates and the way in which they develop separately from each other have been extensively studied, but the genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog（Shh）is one of the key signaling molecules involved in the spatial pattern-ing of teeth and other ectodermal organs such as hair, vibrissae and feathers. Sostdc１，a secreted inhibitor of the Wnt and Bmp pathways, also regulates the spatial patterning of teeth and hair. Here, by utilizing ma-ternal transfer of ５E１（an anti-Shh antibody）to mouse embryos through the placenta, we show that Sostdc １ is downstream of Shh signaling and suggest a Wnt-Shh-Sostdc１ negative feedback loop as a pivotal mechanism controlling the spatial patterning of teeth. Furthermore, we propose a new reaction-diffusion model in which Wnt, Shh and Sostdc１ act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse and can explain the various tooth patterns produced experimentally.

≪プロフィール≫

延世大学校歯科大学 口腔生物学教室 教授 鄭 翰聖

＜Profile＞

１９９５−１９９７ Research Assistant

Developmental Biology, University Col-lege London, UK（Ph.D.）

１９９７−１９９９ Post-Doctoral Research Fellow

University of Helsinki, Institute of Biotech-nology, Finland

１９９９−２０００ Instructor

Harvard Medical School, Cutaenous Biol-ogy Research Center, USA

２０００−present Instructor, Assistant Professor, Associ-ate Professor, and Professor

Dept. of Oral Biology, College of Den-tistry, Yonsei University

２００３−present Adjunct Professor, Tokyo Dental Col-lege, Japan

２０１０−present Vice Dean for Research Affairs Director for BK２１ Project of Yonsei Dental Science

A new feedback loop for spatial patterning of the teeth

Han-Sung Jung, DDS, PhD

Professor Dept of Oral Biology Yonsei University College of Dentistry

姉妹校合同シンポジウム ２０１１．

１０

「トランスレーショナルリサーチの現状」

歯科学報 Vol．１１１，No．４（２０１１） ４１７

参照

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