資源開発研究部門 天然物化学分野
Medicinal Resources
Natural Products Chemistry
教 授 森田 洋行 Hiroyuki Morita 助 教 ウォン チン ピアウ Chin Piow Wong 助 教 児玉 猛 Takeshi Kodama
◆ 原 著
1) Woo S*, Wong CP, Win NN, Hoshino S, Prema, Ngwe H, Abe I, Morita H. A new tetrahydrofuran type lignan from Premna serratifolia wood. Nat Prod Commun. 2019 Jan 1; 14: 113-6. doi: 10.1177/1934578X1901400130.
2) Woo S*, Hoshino S, Wong CP, Win NN, Awoufack MD, Prema, Ngwe H, Zhang H, Hayashi F, Abe I, Morita H.
Lignans with melanogenesis effects from Premna serratifolia wood. Fitoterapia. 2019 Mar; 133: 35-42. doi: 10.1016/
j.fitote.2018.12.008.
3) Ki D*, Awouafack MD, Wong CP, Nguyen HM, Thai QM, Nu LHT, Morita H. Brominated diphenyl ethers including a new tribromoiododiphenyl ether from a Vietnamese marine sponge Arenosclera sp. and their antibacterial activities. Chem Biodivers. 2019 Mar; 16(3): e1800593. doi: 10.1002/cbdv.201800593.
4) Win NN, Kodama T, Lae KZW, Win YY, Ngwe H, Abe I, Morita H. Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar. Fitoterapia. 2019 Apr; 134: 101-7. doi: 10.1016/j.fitote.2019.02.016.
5) Win NN, Kyaw MM, Prema, Ngwe H, Ito T, Asakawa Y, Okamoto Y, Tanaka M, Abe I, Morita H. Dinorcassane diterpenoid from Boesenbergia rotunda rhizomes collected in Lower Myanmar. Chem Biodivers. 2019 Apr; 16(4): e1800657. doi:
10.1002/cbdv.201800657.
6) Feng R, Satoh Y, Morita H, Ogasawara Y, Dairi T. Amino acid residues recognizing isomeric glutamate substrates in UDP-N-acetylmuramic acid-L-alanine-glutamate synthetases. ACS Chem Biol. 2019 May; 14(5): 975-8. doi: 10.1021/
acschembio.9b00159.
7) Prema*, Wong CP, Nugroho AE, Awouafack MD, Win YY, Win NN, Ngwe H, Morita Hiroshi, Morita Hiroyuki. Two new quassinoids and other constituents from Picrasma javanica wood and their biological activities. J Nat Med. 2019 Jun; 73(3):
589-96. doi: 10.1007/s11418-018-01279-z.
8) Hue BTB, Nguyen HM, Hieu MV, Thanh DLD, Son NH, De TQ, Morita H. Facile sodium metabisulfite mediated synthesis of 1,2-disubstituted benzimidazoles and cytotoxicity evaluation. Heterocycles. 2019 Jun 10; 98: 650-65. doi: 10.3987/COM- 19-14071.
9) Nguyen HT, Tran LTT, Ho DV, Phan KV, Raal A, Morita H. Three new inositol derivatives from Chisocheton paniculatus.
Tetrahedron Lett. 2019 Jul 11; 60: 1841-4. doi: 10.1016/j.tetlet.2019.06.015.
10) Hoshino S, Mitsuhashi T, Kikuchi T, Wong CP, Morita H, Awakawa T, Fujita M, Abe I. Structural elucidation of tenebrathin: Cytotoxic C5-substituted a-pyrone with nitroaryl side chain from Streptoalloteichus tenebrarius. Org Lett. 2019 Aug 16; 21(16): 6519-22. doi: 10.1021/acs.orglett.9b02443.
11) Woo S*, Wong CP, Win NN, Lae KZW, Woo B, Elsabbagh SA, Liu QQ, Ngwe H, Morita H. Anti-melanin deposition activity and active constituents of Jatropha multifida stems. J Nat Med. 2019 Sep; 73(4): 805-13. doi: 10.1007/s11418-019- 01314-7.
◆ 総説
1) Morita H, Wong CP, Abe I. How structural subtleties lead to molecular diversity for the type III polyketide synthases. J Biol Chem. 2019 Oct 11; 294(41): 15121-36. doi. 10.1074/jbc.REV119.006129.
◆ 学会報告
1) Morita H. Characterization of two novel plant type III polyketide synthase from Evodia rutaecarpa. 2nd China-Japan Joint
和漢医薬学総合研究所
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Symposium on Natural Product Biosynthesis; 2019 Jan 14-15; Guangzhou, China.（ポスター）．（2018年未掲載分）
2) Morita H. Synthesis of unnatural compounds by enzyme engineering. 2019 International Conference of The Plant Resources Society of Korea; 2019 Apr 25-26; Yeosu, Korea. （招待講演）
3) Wong CP. Inhibitors of AKT signaling pathway and their application. 2019 International Conference of The Plant Resources Society of Korea; 2019 Apr 25-26; Yeosu, Korea. （招待講演）
4) Woo S.*. Melanogenesis regulatory constituents from Prema serratifolia wood collected in Myanmar. 2019 International Conference of The Plant Resources Society of Korea; 2019 Apr 25-26; Yeosu, Korea. （招待講演）
5) Nguyen HM, Nguyen HT, Morita H. New sesquiterpene phenols from a Vietnamese marine sponge of Spongia sp. and their biological activities. Asia Pharm IV; 2019 Aug 28-29; Kuala Lumpur, Malaysian. （ポスター）．
6) Morita H. Engeering of olivetolic cyclase to generate new compounds JST-CRSC「日中分野別ハイレベル研究者交流会 2019」〜医薬･健康編〜；2019 Dec 21-22; Guangzhou, China. （招待講演）
7) Wong CP, Liu Q, Shi S, Morita H. X-ray crystal structure analysis of agarwood type III PKS PECPS 日本薬学会第139年会; 2019 Mar 21-23; 千葉．
8) 森田洋行．ポリケタイド閉環酵素とバイヤービリガー酵素の機能改変と新規化合物の創出．新学術領域生合成 リデザイン第6回公開シンポジウム；2019 May 25-26；札幌．
9) 森田洋行．有用物質生産を目指した二次代謝酵素の酵素工学．フォーラム富山「創薬」第49回研究会；2019
May 27；富山．（招待講演）
10) 森田洋行．天然型･非天然型化合物ライブラリーの構築を目指して．第36回和漢医薬学会学術大会；2019 Aug
31-Sep 1；富山．（シンポジウム・ワークショップパネル）．
11) Morita H, El-Desoky AH,. A new prenylated isoflavan from the Egypt ian wild medicinal plant Lotus Cre t i cus L. 日本生 薬学会代66回年会；2019 Sep 22-23；東京．（ポスター）．
12) 谷畑昂士郎，黒金智文，玉置大介，蒲池浩之，高尾泰昌，黒崎文也，田浦太志，Wong Chin Piow，森田洋行，
唐原一郎．過重力環境がマメ科薬用植物の生長に与える影響．日本宇宙生物科学会第33回大会；2019 Sep 21- 23；千葉．（ポスター）．
◆ その他
1) 森田洋行．Synthesis of unnatural compounds by enzyme engeering. 北京大学薬学院-富山大学和漢医薬学総合研究所 ジョイントセミナー；2019 Oct 10；富山．
2) Morita H. Synthesis of unnatural compounds by enzyme engeering. Sminar on University of Yangon; 2019 Oct 24; Yangon, Myanmar.
3) Morita H. Synthesis of unnatural compounds by enzyme engeering. 2nd Joint Egyptian-Japanese Symposium; 2019 Nov 25;
Cairo.
4) 森田洋行．植物と医薬品. 日本学術振興会カイロ研究連絡センター定例談話会；2019 Nov 26；カイロ．
5) Morita H. Synthesis of unnatural compounds by enzyme engineering. The 80th Anniversary of The Natural Products Research Institute at Seoul National University; 2019 Dec 12; Seoul.
6) Morita H. Engeering of olivetolic cyclase to generate new compounds. JST-CRSC「日中分野別ハイレベル研究者交流 会2019」〜医薬･健康編〜；2019 Dec 21-22; Guangzhou, China.
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