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Summary Evaluation of the Product Specific Standard Input Function for the IMP-ARG Method Tohru S

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Summary

Evaluation of the Product Specific Standard Input Function for the IMP-ARG Method

Tohru S

HIGA

*, Tomohito K

AJI

*, Tomoya K

OHNO

*, Hiroyuki K

AGEYAMA

*, Chietsugu K

ATOH

**, Jun H

ATAZAWA

***, Naohiko O

KU

***, Isamu N

ARABAYASHI

****, Hitoya O

HTA

****,

Tsuyoshi K

OMORI

****, Masuo H

AYASHI

**** and Nagara T

AMAKI

*

*Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine

**Department of Health Sciences, Hokkaido University School of Medicine

***Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine

****Department of Radiology, Osaka Medical College

To confirm the previous reports demonstrating the difference in the octanol extraction fractions between the currently available two N-isopropyl-4-iodoam- phetamine (123I) products (IMPA and IMPB), we newly developed the standard input function for IMPB in 19 healthy volunteers and compared it with the estab- lished standard input function, which has been origi- nally generated with IMPA.

The octanol extraction fractions of IMPB were stable from 5 minutes to 16 minutes post injection and significantly higher than those of IMPA. The mCBFs calculated with IMPB by using the established stan-

dard input function for IMPA tended to be higher than those with the combination of IMPA and the estab- lished standard input function though the difference was not significant.

When measured with IMPB combined with the correspondent standard input function, mCBFs were identical to those calculated with IMPA with the es- tablished standard input function, suggesting that the appropriate standard input function should be used according to the product used.

Key words: IMP, Standard input function, ARG method, CBF.

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