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Effect of sulfonylureas on the changes in QTc interval in non-insulin dependent diabetes mellitus

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BullTMCT 25, 7"'-' 9 , 1996.

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Tadasu IKEDA, Kohsi NARAHASHI*, Keiko OHTAHARA ,* Sachiko TESHIMA'¥Hiroshi OCH

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Katsumi FUJIY A M A *

and Yasushi T A N AKA *

The Department of Nursing, Tottori University College of Medical Care Technology and *The First Department of 1nternal Medicine, Tottori University Faculty of Medicine,

Y onago 683,

J

apan

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The diabetic subjects with prolonged QT interval in electrocardiogram associated with autonomic neuropathy may die suddenly and unexpectedlyl-3l. Thus, the QT interval prolongation has been suggested to predict cardiovascular mortality not only in healthy population but also in diabetes mellitus with autonomic neuropathy4,5l. 1n a previous study6l, we reported that the QTc interval in

diabetic subjects treated with glibenclamide, one of hypoglycemic sulfonylurea drugs, was signifi聞

cantly longer than that treated with diet alone independently of diabetic autonomic neuropathy, and that glibenclamide treatment has been suggested to prolong the QT interva.lBecause of being simple and crosssectional, the previous study has remained equivocal results. Therefore, we made sure by the investigation of the QTc-interval change during two years if it is true or not that the prolongation in diabetic subjects occurs by glibenclamide.

Materials and methods

Subjects

Ninety-one subjects (aged 50-70 yr) with non輔insulindependent diabetes mellitus were enrolled for

the study, in whom the mode of therapy (for insulin, sulfonylureas, or diet) had not been changed over the last two years. Their diabetic condition was stable, and they were treated neither with diuretics, digitalis,β-blockers, nor antiarrhythmic drugs that could potentially interfere with the QT interval.They had no hypertension or abnormal findings on the electrocardiogram monitoring [recent or past myocardial infarction, right or left ventricular hypertrophy (RV 4> 45 min), arrhyth -mias, or ST-T changes]. Thirty幽onesubjects had been treated with insulin, 34 with sulfonylureas (20

with glibenc1amide and 14 with glic1azide), and 26 with diet alone. Clinical features of the subjects were shown in Table l.

M easurements 01 QT interval

All subjects had received every year a standard 12-1ead electrocardiogram. 1n them, 91 subjects with QTc-interval of 380-420 msec were selected from the ECG records in 1992. The records in 1992 were compared with those in 1994. The longest QT interval was measured in leads 1, 1,1or IIL which consists of the length from the first deflection of the QRS complex to the end of the T top, where it merges with the electric baseline. Adjustment for heart rate was made according to Bazett's formula: QTc=QT/JRR6l. Coefficient of variation for the R-R interval (CVR-R) was

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8 Ikeda T et al

determined from 150systoles by the off岨linecalculator of an R-R interval measuring device.

Statistical analyses

The data were expressed as the means土SD.Analysis of variance was used and twoωtailed

Student's nonpaired t test was also used for statistical evaluations.

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The age and the duration of diabetes were not significantly different from those among the four groups as shown in Table 1.The prevalence of diabetic complications was higher in diabetic subjects treated with insulin or sulfonylureas than in those treated with diet alone. HbA1 c value in diabetic subjects treated with insulin was significantly higher than that treated with diet alone.CV R-Rin diabetic subjects treated with insulin(1.78:1:0.80%) was significantly lower than that treated diet alone(2.68士1.22%).QTc interval was not significantly different among the four groups, although the.QTc interval in the subject treated with gliclazide was slightly longer than in other groups. Table1 Clinical features of non-insulin dependent diabetes mellitus

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az i de (n=31) (n=26) (n=20) (n=14) age(yr) 61.916. 2 62. 4士5.7 61.8士5.6 61.616. 4 duration of diabetes (yr) 17.3士7.4 12. 9土7.2 13.717. 1 12.818.2 peripheral neuropathy 26/31 15/26 16/20 9/14 retinopathy 20/31 7/26 12/20 6/14 nephropathy 10/31 5/26 4/20 3/14 serum K (mEq/l) 4.610.4 4.4土0.4 4. 610. 3 4. 510. 3 serum Ca (mg/dl) 8.310.6 8. 510. 6 8. 610. 5 8. 510. 5 HbA

c(児) 1992 8.712. 1本 7.411.0 7.8土0.9 7. 6土1.1 1994 9. 012. 2 7.4土1.1 7.9土1.1 8. 111.2 CVR-R(目) 1.78土0.80本 2. 68土1.22 2. 22土0.80 2.36土0.88 QTc(msec) 1992 410土27 410土25 413土12 411土23 1994 417土20 416土31 415士11 421131 The data are expressed as means土SD.

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Sulfonylureas and QTc interval 9 Discussion The present study clear1y demonstrated that the QTc interval gradually and naturally prolonged in diabetic subjects, and that the sulfonylurea drugs did not influence the prolongation of the QTc interval.The present results were contradictory to the result of our previous report that the QTc interval was significantly longer in the diabetic subject treated with glibenclamide6l . Our previous

report was a cross“sectional study, and it is possible that diabetic subjects who initially had

prolonged QTc interval were included in glibenclamide働treateddiabetic groups. Thus, the reexami -nation of our previous study revealed that three subjects who initially had prolonged QTc interval (> 420 msec) were included in glibenclamide-treated groups although such subjects were not included in diet-or insulin-treated groups. This may mainly be responsible for the previous results. We conclude that sulfonylurea drugs do not enhance the naturallengthening of the QTc interval in NIDDM subjects.

Summary

In a previous study, we reported that QTc interval in diabetic subjects treated with glibenclamide, one of hypoglycemic sulfonylurea drugs, was significantly longer than that treated with diet alone independently of diabetic autonomic neuropathy. We pursued the two years QTc-interval changes in diabetic subjects to elucidate whether or not glibenclamide lengthen the interval.Ninety-one subjects (aged 50-70 yr) with non-insulin dependent diabetes mellitus were enrolled for the study, who had received unchanged therapy (for insulin, sulfonylureas, or diet) over the last two years. The subjects were divided into four groups; 1) 31 subjects treated with insulin, 2) 20 with glivenclamide, 3) 14 with gliclazide, and 4) 26 with diet alone. After 2 years, there were no significant differences in the QTc interval among the four groups, although the QTc interval naturally and slightly prolonged in all groups during the same periods. These results suggest that sulfonylurea drugs do not enhance the naturallengthening of the QTc interval in NIDDM subjects. References

1. Kahn JK, Sisson JC and Vinik AI, J Clin Endocrinol Metabol, 64, 751・754,1987.

2. Chambers JB, Sampson MJ, Sprigings DC and Jackson G, Diabetic Med, 7, 105-110, 1990. 3. Ewing DJ and Clarke BF, Clin Endocrinol Metabol, 15, 855-888, 1986.

4. Schouten EG, Dekker JM, Meppelink P, Kok FJ, Vandenbroucke JP and Pool J, Circulation, 84, 1516-1523, 1991.

5. Ewing DJ, Boland 0, Neilson JMN, Cho CG and Clarke BF, Diabetologia, 34, 182-185, 1991. 6. Ikeda T, Diabete Metab, 20, 565-566, 1994.

7. Bazett HC, Heart, 7, 353-370, 1920.

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