ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌ࡢデ᩿࠾ࡼࡧ㔜ᗘศ㢮ࡢࡓࡵࡢㄪᰝ
ศᢸ◊✲⪅㸸 Ლ 㱟ඤ
ᡤᒓタྡ㸸 ᚨᓥᏛ⚄⤒ෆ⛉
◊✲せ᪨
ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌㸦6WLIISHUVRQV\QGURPH636㸧ࡣࠊయᖿࢆ㒊ࡋ࡚ࠊ 㛫Ḵⓗ➽◳┤ࡸ➽②ᨥࡀⓎ⏕ࡋࠊࡉࡽࡣ㌟≧ࡀ㐍⾜ࡍࡿᝈ࡛࠶ࡿࠋ
ᩘ ✀ 㢮 ࡢ ⮬ ᕫ ᢠ య ࡀ ཎ ᅉ ≀ ㉁ ࡉ ࢀ ࠊ *$%$ ࡢ ⏕ ᡂ 㛵 ࢃ ࡿ ᢠ *$' ᢠ య ࡸ ᢠ DPSKLSK\VLQ ᢠయࡀࠊ≉㔜せどࡉࢀ࡚࠸ࡿࠋᮏ㑥࠾࠸࡚ࡣᮍデ᩿ࡀᏑᅾࡍࡿ
ᐃࡉࢀࠊデ᩿ᇶ‽ࠊᆺศ㢮ࠊ㔜ᗘࢆసᡂࡋࠊᑗ᮶ࡢ㞴་⒪ไᗘࡢᣑᙺ❧
࡚ࡓ࠸ࠋ
㸿.◊✲┠ⓗ
ࢫ ࢸ ࢵ ࣇ ࣃ ࣮ ࢯ ࣥ ೃ ⩌ 㸦 6WLIISHUVRQ V\QGURPH636㸧ࡣࠊ㌟ࡢ➽◳┤ࡸ➽②ᨥ㸦ࡇࡴࡽ
ࡀ࠼ࡾ㸧ࢆࡁࡓࡍ⮬ᕫචᛶᝈ࡛࠶ࡿࠋᩘ✀㢮ࡢ
⮬ᕫᢠయࡀཎᅉ≀㉁ࡉࢀࠊ*$%$ ࡢ⏕ᡂ㛵ࢃࡿᢠ
*$' ᢠయࡸᢠ DPSKLSK\VLQ ᢠయࡀࠊ≉㔜せどࡉࢀ࡚
࠸ࡿࠋ636 ࡣࡁ⮴Ṛⓗ࡞ࡿࡇࡶ࠶ࡾࠊデ᩿ᇶ
‽⒪ࣝࢦࣜࢬ࣒ࡢ☜❧ࡀᛴົ࡛࠶ࡿࠋᅇ ᡃࠎࡣࠊ⮬㦂ࡢㄪᰝࡶࠊ636 ࡢデ᩿ᇶ‽ࠊ
ᆺศ㢮ࠊ㔜ᗘࢆసᡂࡋࡓࠋ 㹀.◊✲᪉ἲ
ࡲࡎࠊᙜタ࡛⤒㦂ࡋࡓ 636 ࡘ࠸࡚ࠊ⮫
ᗋീࢆ᳨ウࡋࡓࠋḟࠊデ᩿ᇶ‽ࠊᆺศ㢮ࠊ㔜
ᗘศ㢮ࢆసᡂࡋࡓࠋ 㸦⌮㠃ࡢ㓄៖㸧
ᅜḟㄪᰝࡢ㛤ጞඛ❧ࡕࠊᚨᓥᏛ㝔⌮
ጤဨࡢᢎㄆࢆᚓࡿࡇࡍࡿࠋ
㹁.◊✲⤖ᯝ
⮬㦂ࡢ᳨ウ㸸
⏨ᛶ ዪᛶ ࠋᖹᆒⓎᖺ㱋ࡣ ṓࠋᆺศ 㢮࡛ࡣࠊྂᆺ 636 ࠊ㝈ᒁᆺ 636 ࠊ⬻ᖿ≧
㝶కᆺ 636 ࠋࡍ࡚ᢠ *$' ᢠయ㝧ᛶᢠయ౯ 8POࠋ༙ᩘ ᆺ⢾ᒀࢆྜేࡋࡓࠋ
⒪ࡣࢫࢸࣟࢻࠊචᢚไࠊ⾑ᾮί⒪ἲࠊච
ࢢࣟࣈࣜࣥ㔞㟼ὀ⒪ἲ,9,Jࠊᢠ②ࡀᢞࡉ
ࢀ࡚࠸ࡓࠋࡑࡢᚋࠊ ࡀṚஸࠊ ࡀ⒪๓ᚋ࡛
PRGLILHG5DQNLQ6FDOHP56ኚ࡞ࡃࠊ ࡛ᨵ ၿP56Ѝࢆㄆࡵࡓࠋ
デ᩿ᇶ‽࣭ᆺศ㢮࣭㔜ᗘศ㢮㸸
࣓ࣜ࢝ᅜ❧⚄⤒ᝈ࣭⬻༞୰◊✲ᡤࡢ⚄⤒➽ᝈ 㒊㛛ࡢデ᩿ᇶ‽ࢆ୍㒊ᨵኚࡋࡓ 636 ࡢデ᩿ᇶ‽⾲
ࢆసᡂࡋࡓࠋࡲࡓࠊᆺศ㢮㸦⾲ 㸧ࠊ㔜ᗘศ㢮 㸦⾲ 㸧ࡘ࠸࡚ࡶ⟇ᐃࡋࡓࠋ
㹂.⪃ᐹ
ዪᛶከ࠸ⅬࡸᖹᆒⓎᖺ㱋ࡣ᪤ሗ࿌㢮ఝࡋ࡚࠸
ࡓ㸦ᩥ⊩ 㸧ࠋ⮬㦂࡛ࡣ᭱㔜ᮇ⾑ᾮί⒪ἲࢆ
⾜࠸ࠊࡑࡢᚋࢫࢸࣟࢻࠊචᢚไຍ࠼ࠊ,9,J
ࢆే⏝ࡋ࡚࠸ࡿࡢࡳࠊ㞀ᐖࢫࢣ࣮ࣝࡀ㛗ᮇⓗ
ᨵၿࡋ࡚࠾ࡾࠊ」ྜⓗ࡞ච⒪ἲࡀணᚋࢆᨵၿࡉࡏ
ࡿྍ⬟ᛶࡀ࠶ࡿࠋ
㏆ᖺࠊ636ࡢᆺࡢࡦࡘ࡛࠶ࡿ3(50࠾࠸࡚ᢠ*O\5 ᢠయࡀ㧗㢖ᗘ᳨ฟࡉࢀࡿࡇࡀሗ࿌ࡉࢀ࡚࠾ࡾࠊ ᮏ㑥࠾࠸࡚ࡶᢠయ⣔ࡢ☜❧ࡀᮃࡲࢀࡿࠋࡲࡓࠊ
ᅜㄪᰝࡢ⤖ᯝࡽࠊᝈ⪅ᩘࡢᢕᥱࠊデ᩿ᇶ‽ࡸ㔜
ᗘศ㢮ࡢ㐺ṇࡘ࠸࡚ࡶ᳨ウࡋࡓ࠸ࠋ 㹃.⤖ㄽ
636ࡢデ᩿ᇶ‽ࠊᆺศ㢮ࠊ㔜ᗘศ㢮ࢆసᡂࡋࡓࠋ
- 16 -
ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌ࡢデ᩿࠾ࡼࡧ㔜ᗘศ㢮ࡢࡓࡵࡢㄪᰝ
ศᢸ◊✲⪅㸸 Ლ 㱟ඤ
ᡤᒓタྡ㸸 ᚨᓥᏛ⚄⤒ෆ⛉
◊✲せ᪨
ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌㸦6WLIISHUVRQV\QGURPH636㸧ࡣࠊయᖿࢆ㒊ࡋ࡚ࠊ 㛫Ḵⓗ➽◳┤ࡸ➽②ᨥࡀⓎ⏕ࡋࠊࡉࡽࡣ㌟≧ࡀ㐍⾜ࡍࡿᝈ࡛࠶ࡿࠋ
ᩘ ✀ 㢮 ࡢ ⮬ ᕫ ᢠ య ࡀ ཎ ᅉ ≀ ㉁ ࡉ ࢀ ࠊ *$%$ ࡢ ⏕ ᡂ 㛵 ࢃ ࡿ ᢠ *$' ᢠ య ࡸ ᢠ DPSKLSK\VLQ ᢠయࡀࠊ≉㔜せどࡉࢀ࡚࠸ࡿࠋᮏ㑥࠾࠸࡚ࡣᮍデ᩿ࡀᏑᅾࡍࡿ
ᐃࡉࢀࠊデ᩿ᇶ‽ࠊᆺศ㢮ࠊ㔜ᗘࢆసᡂࡋࠊᑗ᮶ࡢ㞴་⒪ไᗘࡢᣑᙺ❧
࡚ࡓ࠸ࠋ
㸿.◊✲┠ⓗ
ࢫ ࢸ ࢵ ࣇ ࣃ ࣮ ࢯ ࣥ ೃ ⩌ 㸦 6WLIISHUVRQ V\QGURPH636㸧ࡣࠊ㌟ࡢ➽◳┤ࡸ➽②ᨥ㸦ࡇࡴࡽ
ࡀ࠼ࡾ㸧ࢆࡁࡓࡍ⮬ᕫචᛶᝈ࡛࠶ࡿࠋᩘ✀㢮ࡢ
⮬ᕫᢠయࡀཎᅉ≀㉁ࡉࢀࠊ*$%$ ࡢ⏕ᡂ㛵ࢃࡿᢠ
*$' ᢠయࡸᢠ DPSKLSK\VLQ ᢠయࡀࠊ≉㔜せどࡉࢀ࡚
࠸ࡿࠋ636 ࡣࡁ⮴Ṛⓗ࡞ࡿࡇࡶ࠶ࡾࠊデ᩿ᇶ
‽⒪ࣝࢦࣜࢬ࣒ࡢ☜❧ࡀᛴົ࡛࠶ࡿࠋᅇ ᡃࠎࡣࠊ⮬㦂ࡢㄪᰝࡶࠊ636 ࡢデ᩿ᇶ‽ࠊ
ᆺศ㢮ࠊ㔜ᗘࢆసᡂࡋࡓࠋ 㹀.◊✲᪉ἲ
ࡲࡎࠊᙜタ࡛⤒㦂ࡋࡓ 636 ࡘ࠸࡚ࠊ⮫
ᗋീࢆ᳨ウࡋࡓࠋḟࠊデ᩿ᇶ‽ࠊᆺศ㢮ࠊ㔜
ᗘศ㢮ࢆసᡂࡋࡓࠋ 㸦⌮㠃ࡢ㓄៖㸧
ᅜḟㄪᰝࡢ㛤ጞඛ❧ࡕࠊᚨᓥᏛ㝔⌮
ጤဨࡢᢎㄆࢆᚓࡿࡇࡍࡿࠋ
㹁.◊✲⤖ᯝ
⮬㦂ࡢ᳨ウ㸸
⏨ᛶ ዪᛶ ࠋᖹᆒⓎᖺ㱋ࡣ ṓࠋᆺศ 㢮࡛ࡣࠊྂᆺ 636 ࠊ㝈ᒁᆺ 636 ࠊ⬻ᖿ≧
㝶కᆺ 636 ࠋࡍ࡚ᢠ *$' ᢠయ㝧ᛶᢠయ౯ 8POࠋ༙ᩘ ᆺ⢾ᒀࢆྜేࡋࡓࠋ
⒪ࡣࢫࢸࣟࢻࠊචᢚไࠊ⾑ᾮί⒪ἲࠊච
ࢢࣟࣈࣜࣥ㔞㟼ὀ⒪ἲ,9,Jࠊᢠ②ࡀᢞࡉ
ࢀ࡚࠸ࡓࠋࡑࡢᚋࠊ ࡀṚஸࠊ ࡀ⒪๓ᚋ࡛
PRGLILHG5DQNLQ6FDOHP56ኚ࡞ࡃࠊ ࡛ᨵ ၿP56Ѝࢆㄆࡵࡓࠋ
デ᩿ᇶ‽࣭ᆺศ㢮࣭㔜ᗘศ㢮㸸
࣓ࣜ࢝ᅜ❧⚄⤒ᝈ࣭⬻༞୰◊✲ᡤࡢ⚄⤒➽ᝈ 㒊㛛ࡢデ᩿ᇶ‽ࢆ୍㒊ᨵኚࡋࡓ 636 ࡢデ᩿ᇶ‽⾲
ࢆసᡂࡋࡓࠋࡲࡓࠊᆺศ㢮㸦⾲ 㸧ࠊ㔜ᗘศ㢮 㸦⾲ 㸧ࡘ࠸࡚ࡶ⟇ᐃࡋࡓࠋ
㹂.⪃ᐹ
ዪᛶከ࠸ⅬࡸᖹᆒⓎᖺ㱋ࡣ᪤ሗ࿌㢮ఝࡋ࡚࠸
ࡓ㸦ᩥ⊩ 㸧ࠋ⮬㦂࡛ࡣ᭱㔜ᮇ⾑ᾮί⒪ἲࢆ
⾜࠸ࠊࡑࡢᚋࢫࢸࣟࢻࠊචᢚไຍ࠼ࠊ,9,J
ࢆే⏝ࡋ࡚࠸ࡿࡢࡳࠊ㞀ᐖࢫࢣ࣮ࣝࡀ㛗ᮇⓗ
ᨵၿࡋ࡚࠾ࡾࠊ」ྜⓗ࡞ච⒪ἲࡀணᚋࢆᨵၿࡉࡏ
ࡿྍ⬟ᛶࡀ࠶ࡿࠋ
㏆ᖺࠊ636ࡢᆺࡢࡦࡘ࡛࠶ࡿ3(50࠾࠸࡚ᢠ*O\5 ᢠయࡀ㧗㢖ᗘ᳨ฟࡉࢀࡿࡇࡀሗ࿌ࡉࢀ࡚࠾ࡾࠊ ᮏ㑥࠾࠸࡚ࡶᢠయ⣔ࡢ☜❧ࡀᮃࡲࢀࡿࠋࡲࡓࠊ
ᅜㄪᰝࡢ⤖ᯝࡽࠊᝈ⪅ᩘࡢᢕᥱࠊデ᩿ᇶ‽ࡸ㔜
ᗘศ㢮ࡢ㐺ṇࡘ࠸࡚ࡶ᳨ウࡋࡓ࠸ࠋ 㹃.⤖ㄽ
636ࡢデ᩿ᇶ‽ࠊᆺศ㢮ࠊ㔜ᗘศ㢮ࢆసᡂࡋࡓࠋ
⾲636ࡢデ᩿ᇶ‽ᩥ⊩ࢆᨵゞ
$ ⮫ᗋᇶ‽
ᅄ⫥࠾ࡼࡧయᖿ࠾ࡅࡿ㐍⾜ᛶࡢ➽◳┤
ᨭᣢᡤぢ⭡㒊࠾ࡼࡧ⬚⭜㒊ࡢഐ⬨ᰕ➽ࡣዲⓎ㒊
࡛࠶ࡾࠊయࡢᅇ㌿ᒅ᭤ࡀᅔ㞴࡞ࡿࠋࡓࡔࡋࠊୗ
⫥ࡢࡳ≧ࡀ㝈ᒁࡍࡿࡇࡶ࠶ࡿࠋ ➽◳┤㔜࡞ࡗ࡚⌧ࢀࡿつ๎࡞②ᨥ
ᨭᣢᡤぢணእࡢ㡢ࠊゐぬ่⃭ࠊឤⓗ࡞ືᦂ
ࡼࡾㄏⓎࡉࢀࡿࠋⓎసᛶࡢ②ᨥࡣ⪏࠼㞴࠸③ࡳࢆక
࠺ࡇࡀ࠶ࡿ
సື➽ᣕᢠ➽ࡢ㐃⥆ඹྠ⦰
㝶ព㐠ືࡀᅔ㞴࡞ࡿࡀࠊཎ๎ࡋ࡚ぬⓗ㐠
ື࣭ឤぬ⣔ࡣṇᖖ
⬻ᖿ≧║⌫㐠ື㞀ᐖࠊ㞴⫈ࠊᵓ㡢࣭ᄟୗ㞀ᐖ࡞
ࡸ࣑࢜ࢡ࣮ࣟࢾࢫࢆక࠺ࡇࡀ࠶ࡿ
%᳨ᰝᡤぢ
⮬ᕫᢠయࡢᏑᅾ
㟁Ẽ⏕⌮Ꮫⓗ᳨ᰝࡼࡿసື➽ᣕᢠ➽ࡢ㐃⥆
ඹྠ⦰ࡢ☜ㄆ
ࢪࢮࣃ࣒ᢞᚋࡶࡋࡃࡣ╧╀ࡼࡿ➽◳┤ࡢ ᨵၿ
*$'ࠊDPSKLSK\VLQࠊJHSKHULQࠊ*$%$$5ࠊ*O\5ࡢᢠ ཎᑐࡍࡿ⮬ᕫᢠయ
㸺௨ୗࡣཧ⪃ᡤぢ㸼
࣭ ᢠ *$' ᢠయ㝧ᛶ 636 ࡛ࡣࠊ ᆺ⢾ᒀᝈ⪅᳨࡛ฟ ࡉࢀࡿࡼ࠺࡞పຊ౯ࡢᢠ *$' ᢠయࡣᑐ↷ⓗ
㧗ຊ౯ࡢᢠ *$' ᢠయࡀ᳨ฟࡉࢀࡿ
࣭ ᢠ *$' ᢠయ㝧ᛶ 636 ࡛ࡣࠊ㧊⭍ෆ࡛ࡢᢠయ⏘⏕ࢆ
ㄆࡵࡿ
࣭ ࡑࡢࡢ⮬ᕫචᝈ⏥≧⭢⅖࡞ࠊ ᆺ⢾ᒀ
ࡢྜే
&㚷ูデ᩿
➽◳┤➽②ᨥࢆ≧ࡍࡿࡢᝈࢨࢵࢡ ࢫೃ⩌ࠊࢪࢫࢺࢽࠊ0F$UGOH࡞ࡢ㝖እ デ᩿ᇶ‽!
'HILQLWH㸸⮫ᗋᇶ‽᳨ᰝᡤぢࡢࡍ࡚‶ࡓࡋࠊ&
ࡢ㚷ูࡍࡁᝈࢆ㝖እ
3UREDEOH㸸⮫ᗋᇶ‽ࡢ᳨࡚ᰝᡤぢࡢ 㡯┠ࢆ‶
ࡓࡋࠊ& ࡢ㚷ูࡍࡁᝈࢆ㝖እ
3RVVLEOH㸸⮫ᗋᇶ‽ࡢ᳨࡚ᰝᡤぢࡢ࠺ࡕ 㡯┠
ࢆ‶ࡓࡋࠊ& ࡢ㚷ูࡍࡁᝈࢆ㝖እ
⾲636ࡢᆺ
ձྂᆺ㸸యᖿࢆయࡋࠊ㌟≧ࡀἼཬࡍࡿ
ྂᆺ 636
ղ㝈ᒁᆺ㸸ୗ⫥ẚ㍑ⓗ㝈ᒁࠊVWLIIOLPEೃ⩌
6/6ࡶ࠸࠺
ճSURJUHVVLYHHQFHSKDORP\HOLWLVZLWKULJLGLW\
DQGP\RFORQXV3(50㸸ᙉ┤࣑࢜ࢡ࣮ࣟࢾࢫࢆక
࠺⬻ᖿ≧㝶కᆺ
⾲ 636ࡢ㔜ᗘศ㢮
PRGLILHG5DQNLQ6FDOH ௨ୖࢆᑐ㇟ࡍࡿ
0F.HRQ$HWDO$UFK1HXURO 'DODNDV0&HWDO1HXURORJ\
- 17 -
㹄◊✲Ⓨ⾲
㸯㸧ᅜෆ
ཱྀ㢌Ⓨ⾲ 㸦㸧௳
ཎⴭㄽᩥࡼࡿⓎ⾲ 㸦㸧௳
ࡑࢀ௨እ㸦ࣞࣅ࣮ࣗ࡞㸧ࡢⓎ⾲㸦㸧௳
ࡑࡢ࠺ࡕ࡞ࡶࡢ ㄽᩥⓎ⾲
ᯇᑦᏊࠊ୰᰿ಇᡂࠊᲚ 㱟ඤ
≉㞟㸸චᛶ࣭⅖ᛶ⚄⤒ᝈѸែゎ᫂ࡽᝈ ಟ㣭⸆㛤Ⓨࡲ࡛ ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌
Modern Physician 2016;36(7):745-747 ᯇᑦᏊࠊᲚ㱟ඤ
≉㞟㸸චᛶ⚄⤒ᝈ
៏ᛶ⅖ᛶ⬺㧊ᛶከⓎ᰿ࢽ࣮ࣗࣟࣃࢳ࣮ࠊከᕢᛶ㐠
ືࢽ࣮ࣗࣟࣃࢳ࣮デ⒪࢞ࢻࣛࣥ2013ࡢせⅬ
᪥ᮏ⮫ᗋ2015;73(7):419-421 ᯇᑦᏊࠊᐑᇛឡࠊྂᕝ㈗
≉㞟㸸චᛶ⚄⤒ᝈ
ከᕢᛶ㐠ືࢽ࣮ࣗࣟࣃࢳ࣮(MMN)ࡢᏛ࣭≧⚄
⤒ೃ࣭Ⓨᶵᗎ
᪥ᮏ⮫ᗋ 4. ᯇᑦᏊࠊྂᕝ㈗ࠊᲚ㻌 㱟ඤ
ከᕢᛶ㐠ື䝙䝳䞊䝻䝟䝏䞊䠄MMN䠅㻌 ែ䛸᳨ᰝᡤぢ GBS䛸CIDP䌦デ⒪New Standards
Clinical Neuroscience㻌2014;32(3):324-326
ᏛⓎ⾲
Ṋෆಇ᫂䚸ᯇᑦᏊ䚸ྂᕝ㈗䚸୰᰿ಇᡂ䚸 す⏣႐ᙪ䚸Ლ㻌 㱟ඤ
ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌ࡢ⮫ᗋീ⒪ࡢ᳨ウ
➨57ᅇ᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ⚄ᡞࠊ2016 ᐑᓮ⏤㐨ࠊᯇᑦᏊࠊᲚ㱟ඤ
චᛶࢽ࣮ࣗࣟࣃࢳ࣮࠾ࡅࡿIVIg๓ᚋࡢ⾑ΎIgG
್ࡢኚື
➨57ᅇ᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ⚄ᡞࠊ2016 ᯇᑦᏊ䚸㔝ᑎ⿱அࠊ㧗ᯇ┤Ꮚࠊᑎ⃝⏤ెࠊ
᳃ᩔᏊࠊᓥ㇂ెගࠊᓮ⿱ுࠊᒣࢧࣛࢹ࣮ࢽᜨᏊࠊ
Ἠ၏ಙ䚸Ლ㻌 㱟ඤ
ୗ⭣୕㢌➽䛻䛚䛡䜛䜶䝁䞊㍤ᗘ䛾ゎ㞳䛿ᑒධయ➽⅖䛻≉
ᚩⓗ䛷䛒䜛
➨57ᅇ᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ⚄ᡞࠊ2016 4. ྂᕝ㈗ࠊᯇᑦᏊࠊᐑᇛឡࠊ㔝ᑎ⿱அࠊ⸨⏣ᾈ
ྖࠊἨ၏ಙࠊΎỈᩥ⚅䚸ᐑᮏ୍ࠊ㧗ᶫᖾࠊ⚄⏣
㝯ࠊᴋ㐍ࠊᲚ㱟ඤ
MMNࡢࢧࢺ࣭࢝ࣥࢣࣔ࢝ࣥࣉࣟࣇࣝ
➨56᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ᪂₲ࠊ2015
㸰㸧ᾏእ
ཱྀ㢌Ⓨ⾲ 㸦2㸧௳
ཎⴭㄽᩥࡼࡿⓎ⾲ 㸦7㸧௳
ࡑࢀ௨እ㸦ࣞࣅ࣮ࣗ࡞㸧ࡢⓎ⾲ 㸦0㸧௳
ࡑࡢ࠺ࡕ࡞ࡶࡢ ㄽᩥⓎ⾲
1. Nakane S, Furutani K, Harada M, Urushihara R, Matsui N, Izumi Y, Kaji R.
Multimodal analysis based on high-field magnetic resonance and motor evoked potentials: A case report of multiple sclerosis.
Clinical and Experimental Neuroimmunology 2016 doi: 10. 11 11/cen3.12352
2. Kamata M, Nakane S, Matsui N, Higuchi O, Sakai W, Fujita K, Izumi Y, Matsuo H, Kaji R.
Ocular myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies:
Two new cases and a systematic literature review.
Clinical and Experimental Neuroimmunology 2016 doi: 10. 11 11/cen3.12296
3. Nodera H, Takamatsu N, Matsui N, Mori A, Terasawa Y, Shimatani Y, Osaki Y, Maruyama K, Izumi Y, Kaji R.
Intramuscular dissociation of echogenicity in the triceps surae characterizes sporadic inclusion body myositis.
Eur J Neurol, 2016; 23(3): 588-596
4. Sakai W, Matsui N, Ishida M, Furukawa T, Miyazaki Y, Fujita K, Miyamoto R, Yamamoto N, Sako W, Sato K, Kondo K, Nishida Y, Mitsui T, Izumi Y, Kaji R.
Late-onset myasthenia gravis is predisposed to
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㹄◊✲Ⓨ⾲
㸯㸧ᅜෆ
ཱྀ㢌Ⓨ⾲ 㸦㸧௳
ཎⴭㄽᩥࡼࡿⓎ⾲ 㸦㸧௳
ࡑࢀ௨እ㸦ࣞࣅ࣮ࣗ࡞㸧ࡢⓎ⾲㸦㸧௳
ࡑࡢ࠺ࡕ࡞ࡶࡢ ㄽᩥⓎ⾲
ᯇᑦᏊࠊ୰᰿ಇᡂࠊᲚ 㱟ඤ
≉㞟㸸චᛶ࣭⅖ᛶ⚄⤒ᝈѸែゎ᫂ࡽᝈ ಟ㣭⸆㛤Ⓨࡲ࡛ ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌
Modern Physician 2016;36(7):745-747 ᯇᑦᏊࠊᲚ㱟ඤ
≉㞟㸸චᛶ⚄⤒ᝈ
៏ᛶ⅖ᛶ⬺㧊ᛶከⓎ᰿ࢽ࣮ࣗࣟࣃࢳ࣮ࠊከᕢᛶ㐠
ືࢽ࣮ࣗࣟࣃࢳ࣮デ⒪࢞ࢻࣛࣥ2013ࡢせⅬ
᪥ᮏ⮫ᗋ2015;73(7):419-421 ᯇᑦᏊࠊᐑᇛឡࠊྂᕝ㈗
≉㞟㸸චᛶ⚄⤒ᝈ
ከᕢᛶ㐠ືࢽ࣮ࣗࣟࣃࢳ࣮(MMN)ࡢᏛ࣭≧⚄
⤒ೃ࣭Ⓨᶵᗎ
᪥ᮏ⮫ᗋ 4. ᯇᑦᏊࠊྂᕝ㈗ࠊᲚ㻌 㱟ඤ
ከᕢᛶ㐠ື䝙䝳䞊䝻䝟䝏䞊䠄MMN䠅㻌 ែ䛸᳨ᰝᡤぢ GBS䛸CIDP䌦デ⒪New Standards
Clinical Neuroscience㻌2014;32(3):324-326
ᏛⓎ⾲
Ṋෆಇ᫂䚸ᯇᑦᏊ䚸ྂᕝ㈗䚸୰᰿ಇᡂ䚸 す⏣႐ᙪ䚸Ლ㻌 㱟ඤ
ࢫࢸࢵࣇࣃ࣮ࢯࣥೃ⩌ࡢ⮫ᗋീ⒪ࡢ᳨ウ
➨57ᅇ᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ⚄ᡞࠊ2016 ᐑᓮ⏤㐨ࠊᯇᑦᏊࠊᲚ㱟ඤ
චᛶࢽ࣮ࣗࣟࣃࢳ࣮࠾ࡅࡿIVIg๓ᚋࡢ⾑ΎIgG
್ࡢኚື
➨57ᅇ᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ⚄ᡞࠊ2016 ᯇᑦᏊ䚸㔝ᑎ⿱அࠊ㧗ᯇ┤Ꮚࠊᑎ⃝⏤ెࠊ
᳃ᩔᏊࠊᓥ㇂ెගࠊᓮ⿱ுࠊᒣࢧࣛࢹ࣮ࢽᜨᏊࠊ
Ἠ၏ಙ䚸Ლ㻌 㱟ඤ
ୗ⭣୕㢌➽䛻䛚䛡䜛䜶䝁䞊㍤ᗘ䛾ゎ㞳䛿ᑒධయ➽⅖䛻≉
ᚩⓗ䛷䛒䜛
➨57ᅇ᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ⚄ᡞࠊ2016 4. ྂᕝ㈗ࠊᯇᑦᏊࠊᐑᇛឡࠊ㔝ᑎ⿱அࠊ⸨⏣ᾈ
ྖࠊἨ၏ಙࠊΎỈᩥ⚅䚸ᐑᮏ୍ࠊ㧗ᶫᖾࠊ⚄⏣
㝯ࠊᴋ㐍ࠊᲚ㱟ඤ
MMNࡢࢧࢺ࣭࢝ࣥࢣࣔ࢝ࣥࣉࣟࣇࣝ
➨56᪥ᮏ⚄⤒ᏛᏛ⾡ࠊ᪂₲ࠊ2015
㸰㸧ᾏእ
ཱྀ㢌Ⓨ⾲ 㸦2㸧௳
ཎⴭㄽᩥࡼࡿⓎ⾲ 㸦7㸧௳
ࡑࢀ௨እ㸦ࣞࣅ࣮ࣗ࡞㸧ࡢⓎ⾲ 㸦0㸧௳
ࡑࡢ࠺ࡕ࡞ࡶࡢ ㄽᩥⓎ⾲
1. Nakane S, Furutani K, Harada M, Urushihara R, Matsui N, Izumi Y, Kaji R.
Multimodal analysis based on high-field magnetic resonance and motor evoked potentials: A case report of multiple sclerosis.
Clinical and Experimental Neuroimmunology 2016 doi: 10. 11 11/cen3.12352
2. Kamata M, Nakane S, Matsui N, Higuchi O, Sakai W, Fujita K, Izumi Y, Matsuo H, Kaji R.
Ocular myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies:
Two new cases and a systematic literature review.
Clinical and Experimental Neuroimmunology 2016 doi: 10. 11 11/cen3.12296
3. Nodera H, Takamatsu N, Matsui N, Mori A, Terasawa Y, Shimatani Y, Osaki Y, Maruyama K, Izumi Y, Kaji R.
Intramuscular dissociation of echogenicity in the triceps surae characterizes sporadic inclusion body myositis.
Eur J Neurol, 2016; 23(3): 588-596
4. Sakai W, Matsui N, Ishida M, Furukawa T, Miyazaki Y, Fujita K, Miyamoto R, Yamamoto N, Sako W, Sato K, Kondo K, Nishida Y, Mitsui T, Izumi Y, Kaji R.
Late-onset myasthenia gravis is predisposed to
become generalized in the elderly.
eNeurologicalSci, 2016;2:17-20
5. Furukawa T, Matsui N, Fujita K, Nodera H, Shimizu F, Miyamoto K, Takahashi Y, Kanda T, Kusunoki S, Izumi Y, Kaji R.
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy.
Neurol Neuroimmunol Neuroinflammation 2015; 2(5): e138 doi:10.1212/NXI.
0000000000000138.
6. Miyashiro A, Matsui N, Shimatani Y, Nodera H, Izumi Y, Kuwabara S, Baba M, Komori T, Sonoo M, Mezaki T, Kawamata J, Hitomi T, Imai T, Kohara N, Arimura K, Hashimoto S, Arisawa K, Kusunoki S, Kaji R.
Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan.
Muscle Nerve 2014; 49(3): 357-61.
7. Furukawa T, Matsui N, Fujita K, Miyashiro A, Nodera H, Izumi Y, Shimizu F, Miyamoto K, Takahashi Y, Kanda T, Kusunoki S, Kaji R.
Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy.
J Neurol Sci 2014; 346(1-2):75-79.
doi: 10.1016/j.jns.2014.07.059.
ᏛⓎ⾲
1. Furukawa T, Matsui N, Fujita K, Nodera H, Shimizu F, Miyamoto K, Takahashi Y, Kanda T, Kusunoki S, Izumi Y, Kaji R.
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy.
1st Congress of the European Academy of Neurology Berlin, Germany, 2015
2. Matsui N, Kaji R.
Increased number of Hassall’s corpuscles in myasthenia gravis patients with thymic hyperplasia.
The 66th American Academy of Neurology Annual Meeting
Philadelphia, USA, 2014
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㸰.ᐇ⏝᪂Ⓩ㘓
࡞ࡋ 㸱.ࡑࡢ
࡞ࡋ
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