臨床科学研究部門 Clinical Sciences

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臨床科学研究部門

Clinical Sciences 臨床利用分野 Clinical Application

教授浜崎智仁 Tomohito Hamazaki 准教授渡辺志朗 Shiro Watanabe 助手長澤哲郎 Tetsuro Nagasawa

◆ 著書

1) Hamazaki T., Kirihara Y.: Correlation between low cholesterol levels and high all-cause mortality -results from meta-analysis in Japan-, In what areas are traditional / alternative medicimes useful? Hamazaki T., Nagasawa T., Okuyama H.(ed.) 19-27, Proceedings of 11th International Symposium on Traditional Medicine in Toyama 2007, 2008.

2) Hamazaki T., Okuyama H.: The Japanese Experience. High Cholesterol is Not an Important Risk Factor of All-Cause Mortality, Wild-Type Food in Health Promotion and Disease Prevention. The Columbus Concept, Fabien De Meester, Ronald Ross Watson. (ed.) 21-28, Humana Press INC. Totawa, New Jersey, 2008.

3) Awale S., Hamazaki T., Kadowaki M., Saiki I., Tezuka Y., Kadota S.: Chapter 4 Commonly Encountered diseases in Traditional Medicine, Myanmar Traditional Medicine Handbook. MINISTRY OF HEALTH Department of Traditional Medicine, 99-120, 2008.

◆ 原著

1) Itomura M., Fujioka S., Hamazaki K., Kobayashi K., Nagasawa T., Sawazaki S., Kirihara Y., and Hamazaki T.: Factors Influencing EPA+DHA Levels in Red Blood Cells in Japan. in vivo, 22: 131-136, 2008.

2) Kirihara Y.*, Hamazaki K., Hamazaki T., Ogushi Y., Tsuji H., and Shirasaki S.: The Relationship between Total Blood Cholesterol Levels and All-cause Mortality in Fukui City, and Meta-analysis of This Relationship in Japan. J. Lipid Nutr., 17:

67-78, 2008.

3) Hamazaki K., Din Syafruddin., Insan S Tunru., Marina F Azwir., Puji BS Asih., Sawazaki S., and Hamazaki T.: The effect of docosahexaenoic acid-rich fish oil on behavior, school attendance rate and malaria infection in school children –a double-blind, randomized, placebo-controlled traial in Lampung, Indonesia. Asia Pac J Clin Nutr., 17: 258-263, 2008.

4) Hamazaki T., Shimokawa H., Terashima Y., Itomura M., Hamazaki K., Nagasawa T.,Yamamoto J., and Jun Wu.: The Fatty Acid Composition of Red Blood Cells in Mildly Demented Dogs and of Commercially Available Dog Foods in Japan. J. Lipid Nutr., 17: 163-171, 2008.

5) Higashihara E., Nutahara K., Horie S., Muto S., Hosoya T., Hanaoka K., Tuchiya K., Kamura K., Takaichi K., Ubara Y., Itomura M., and Hamazaki T.: The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD.

Nephrol Dial Transplant., 23: 2847-2852, 2008.

6) Itomura M., Terashima Y., Hamazaki K., Inoue K., Shirato N., Shibahara N., and Hamazaki T.: The Effects of a New Kanpo Formula, Hogen-ou, on Psychological Distress and Low-Grade Inflammation－A Placebo-Controlled Double-Blind Study.

Current Topics in Nutraceutical Research, 6:145-148, 2008.

7) Yoshizumi K., Murota K., Watanabe S., Tomi H., Tsuji T., and Terao J.: Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents. Biosci. Biotechnol. Biochem., 72: 1126–1129, 2008.

8) Watanabe S., Yamada Y., Dobashi K., and Saito M.: Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice. J. Trad. Med., 25:55-59, 2008.

9) Dobashi K.*, Ohkoshi E., Fujii Y., Nagai M. and Watanabe S.: Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice. J. Trad. Med., 25:81-86, 2008.

10) Saito M. * and Watanabe S.: Differential modulation by dexamethasone treatment of lipopolysaccharide- and zymosan-induced hypophagia in mice. Pharmacol. Biochem. Behav., 90: 428-433, 2008.

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◆ 総説

1) Hamazaki T., Hamazaki K.: Fish oils and aggression or hostility. Prog lipid res., 47: 221-232, 2008.

2) 浜崎智仁，糸村美保 : 飽和脂肪酸→コレステロール→冠動脈疾患を再検する Reconsideration of the Sequence of Saturated Fatty Acids, Cholesterol and Coronary Heart Disease in Japan. オレオサイエンス, 8: 429-436, 2008.

3) 浜崎智仁, 糸村美保：第1部機能性食品成分, 第16章不飽和脂肪酸の健康効果, 第9節n-3系脂肪酸と行動, 食品機能性の科学, 544-547, 2008.

4) 浜崎景, 浜崎智仁 : 第9章ブレインフード系，第3節臨床現場におけるブレインフードの応用，アンチエイジング・ヘルスフードー抗加齢・疾病予防・健康長寿延長への応用ー，243-249, 2008.

5) 渡辺志朗, 奥山治美 : 第16章第７節不飽和脂肪酸の健康効果 n-3 系脂肪酸の抗炎症, 抗アレルギー作用, 食品機能性の科学, 538-541, 2008.

◆ 学会報告

1) Hamazaki T. : The high omega-3/high cholesterol' healthy diet. 6th International Congress on the Columbus Concept. 2008, 10, 9, Geneva. (Invited lecture)

2) Hamazaki T. : Clinical Trials of Omega3 Fatty Acid containing Food Administration on Symptoms of Attention-Deficit / Hyperactivity Disorder – our experience and others. 2nd WFSBP Asia-Pacific Congress. 2008, 9, 11-13, Toyama. (Invited lecture)

3) Hamazaki T., Suzuki N., Widyowati R., Miyahara T., Kadota S., Ochiai H., Hamazaki K.: The Effect of n-9 Eicosatrienoic acid.

8th Congress of the International Society for the Study of Fatty Acids and Lipids. 2008, 5, 17-22, Kansas City. (Invited lecture) 4) Hamazaki K., TerashimaY., Itomura M., Sawazaki S., Inagaki H., KurodaM., Tomita S., Hirata H., Hamazaki T. : N-3 Fatty

Acids and Survival of Hemodialysis Patients. 8th Congress of the International Society for the Study of Fatty Acids and Lipids.

2008, 5, 17-22, Kansas City.

5) Hamazaki-Fujita N., Kosuge H., Yomoda S., Itomura M., Terashima Y., Hamazaki K., Hamazaki T. : Relationship Between Fatty Acids in RBCS and Skin Conditions. 8th Congress of the International Society for the Study of Fatty Acids and Lipids.

2008, 5, 17-22, Kansas City.

6) 浜崎智仁 : 脂質と精神, 日本脂質栄養学会サテライトシンポジウム「脳機能・行動・神経症に影響を与える脂質栄養」2008, 9, 7, 大阪.（招待講演）

7) 浜崎智仁 : 血清コレステロール値（あるいは LDL-コレステロール値）に上限をもうけることはほとんど無意味, 第 17 回大会日本脂質栄養学会，シンポジウム「コレステロールを多方面から考えるー日本動脈硬化学会との合同シンポジウムー」2008, 9, 6, 大阪.（招待講演）

8) 浜崎景，寺島嘉宏，糸村美保，澤崎茂樹，稲垣均，黒田昌宏，富田新，平田仁，浜崎智仁 : 透析患者において n-3 系多価不飽和脂肪酸が生命予後に及ぼす影響, 第17回大会日本脂質栄養学会，2008, 9, 5-6, 大阪.

9) 渡辺志朗, 山田泰広, 土橋一輝, 斎藤正隆 : オウゴンエキスがインドメタシンにより誘発される小腸における粘膜傷害と炎症性サイトカインの遺伝子発現に及ぼす影響,日本薬学会第 128 年会, 2008, 3, 26-28, 横浜.

10) 渡辺志朗, 土橋一輝 : オウゴンエキスがジクロフェナクナトリウムにより誘発される小腸粘膜傷害に及ぼす影響, 第 25 回和漢医薬医学会大会, 2008, 8, 30-31, 大阪.

◆ その他

1) Inagaki H., Satoh T., Kamiya K., Mori T., Nomura T., Hamazaki T., and Hamazaki K.: (Letter to the editor) Simplest method to prevent rust formation at the nipple connecting the hemodialysis console and dialysate tube. Cllinical Nephrology, 70:185-186, 2008.

2) Hamazaki T., Hamazaki K.: Letters to the Editor Why so thin? Eur J Clin Nutr., 62: 1252-1254, 2008.

3) 浜崎智仁 : 低コレステロールは危険メタ分析で研究結果を裏付け,実業之富山4: 49, 2008.

4) 浜崎智仁 :「コレステロール値は高いと死ににくい」,青淵（渋沢栄一祈念財団）, 26-28, 2008.

5) 浜崎智仁 :「コレステロール下げる必要はない！高いほうが長生きできる！」, 安心, 8 月号130-133, 2008.

6) 浜崎智仁 : 研究室から, 脂質の研究をする，富薬 9 号 30 巻No.230, p6.

7) 浜崎智仁 : 調査研究, 国際協力機構（JICA），短期派遣専門家業務，ミャンマー伝統医療プロジェクト,2008, 3, 18-26， 2008, 11, 29-12, 10, ミャンマー.