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分子神経生物学研究室 Molecular Neurobiology

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分子神経生物学研究室

Molecular Neurobiology

准教授 田渕 明子 Akiko Tabuchi 助 教 伊原 大輔 Daisuke Ihara 助 教(前) 福地 守 Mamoru Fukuchi

◆ 原 著

1) Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Maehata Y, Tabuchi A, Tsuda M. Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice. Sci Rep. 2017 Jul 10;

7(1): 4949.

2) Fukuchi M, Sanabe T, Watanabe T, Kubota T, Tabuchi A, Tsuda M. Distinct regulation of activity-dependent transcription of immediate early genes in cultured rat cortical neurons. Biochem Biophys Res Commun. 2017 Aug 26; 490(3): 682-7.

3) Kikuchi K*, Shiota J, Yamada T, Ishikawa M, Ihara D, Fukuchi M, Tsuda M, Tabuchi A. Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons. Biochem Biophys Res Commun. 2017 Oct 21;

492(3): 474-9.

4) Ihara D, Fukuchi M, Katakai M, Shinoda Y, Katoh-Semba R, Furuichi T, Ishikawa M, Tabuchi A, Tsuda M. Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways. Cell Struct Funct. 2017 Oct 28;

42(2): 141-8.

◆ 総 説

1) Fukuchi M, Tsuda M. Convergence of neurotransmissions at synapse on IEG regulation in nucleus. Front Biosci (Landmark Ed). 2017 Mar 1; 22: 1052-72.

2) 福地 守.神経可塑性の分子基盤を担う遺伝子発現制御系の解明.薬学雑誌.2017 Sep137(9)1103-15

◆ 学会報告

1) 金田真理彩*,阪上洋行,佐藤夏美,石橋悠太,福地 守,津田正明,田渕明子.SRF 転写活性化因子MKL1およ MKL2に対する新たな高品質抗体の作製およびシナプス局在解析.日本生化学会北陸支部第35回大会;2017 Jun

3;金沢.

2) 金田真理彩*,阪上洋行,佐藤夏美,石橋悠太,福地 守,津田正明,田渕明子.SRF 転写活性化因子MKL1およ MKL2の新たな高品質抗体の検討およびシナプス局在解析.第40回日本神経科学大会;2017 Jul 20-23;幕張.

3) 田邉広樹*,田中拓郎,石橋悠太,庄司しずく,久保友喜美,袴田知之,阪上洋行,福地 守,奥野浩行,尾藤晴彦,

津田正明,田渕明子.SRF転写活性化因子MKL2の機能解析:新規アイソフォームSOLOISTを中心として.第40 回日本神経科学大会;2017 Jul 20-23;幕張.

4) 福地 守,森 寿,柴原直利,田渕明子,津田正明.BDNF-Luciferaseトランスジェニックマウス由来大脳皮質ニュ ーロン初代培養系を利用したBDNF 遺伝子転写活性化剤のスクリーニング.第 40回日本神経科学大会;2017 Jul 20-23;幕張.

5) Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Maehata Y, Tabuchi A, Tsuda M. Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice. 60回日本神経化学会 大会;2017 Sep 7-9;仙台.

6) Tabuchi A, Fukuchi M, Kikuchi K, Kubo Y, Shoji S, Hakamata T, Tanaka T, Satou N, Ishibashi Y, Kaneda K, Sakagami H, Bito H, Okuno H, Ohtsuka T, Tsuda M. Regulation of gene expression and morphological alteration by SRF cofactor MKL in neuronal cells. 40回日本分子生物学会年会第90回日本生化学会大会合同大会;2017 Dec 6-9;神戸.

7) Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Tabuchi A, Tsuda M. Measuring changes in BDNF gene expression using bioluminescence signal. 40回日本分子生物学会年会第90回日本生化学会大会合同大会;2017 Dec 6-9;神戸.

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◆ その他

1) 金田 真理彩*.日本生化学会北陸支部第35回大会 学生ベスト発表賞;2017 Jun 3;金沢.

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