Title 重輓馬における超音波画像検査を利用した卵巣・子宮の診断基準の策定( 本文(Fulltext) ) Author(s) 三木, 渉 Report No.(Doctoral Degree) 博士(獣医学) 甲第533号 Issue Date 2019-03-13 Type 博士論文 Version ETD URL http://hdl.handle.net/20.500.12099/77964 ※この資料の著作権は、各資料の著者・学協会・出版社等に帰属します。
㔜㍛㤿࠾ࡅࡿ㉸㡢Ἴ⏬ീ᳨ᰝࢆ⏝ࡋࡓ
༸ᕢ࣭Ꮚᐑࡢデ᩿ᇶ‽ࡢ⟇ᐃ
㸰㸮㸯㸶ᖺ
ᒱ㜧ᏛᏛ㝔㐃ྜ⋇་Ꮫ◊✲⛉
㸦ᖏᗈ␆⏘Ꮫ㸧
୕ᮌ ΅
㔜㍛㤿࠾ࡅࡿ㉸㡢Ἴ⏬ീ᳨ᰝࢆ⏝ࡋࡓ
༸ᕢ࣭Ꮚᐑࡢデ᩿ᇶ‽ࡢ⟇ᐃ
┠ḟ ㅖゝ ... 1 㝃㸧ᅗ⾲ ... 7 ➨㸯❶ 㔜㍛㤿㞤㤿࠾ࡅࡿ㓄㐺ᮇࡢᣦᶆ࠾ࡼࡧGnRH 㢮ఝయࣈࢭࣞࣜࣥ༢ᅇᢞࡀ ༸ྠᮇෆศἪືែཬࡰࡍᙳ㡪 1-1, ᗎㄽ ... 13 1-2, ヨ㦂ᴫせ ... 15 1-2-1, ౪ヨ㤿 ... 15 1-2-2, ࣈࢭࣞࣜࣥᢞ㔞ࡢ᳨ウ ... 15 1-2-3, ヨ㦂᪉ἲ ... 16 1-2-4, ᥇⾑ ... 17 1-2-5, ෆศἪືែࡢほᐹ ... 17 ࣭㯤యᙧᡂ࣍ࣝࣔࣥ㸦LH㸧 ... 17 ࣭༸⬊่⃭࣍ࣝࣔࣥ㸦FSH㸧 ... 18 ࣭࢚ࢫࢺࣛࢪ࣮࢜ࣝ-17ș㸦E㸰㸧 ... 19 ࣭ࣉࣟࢪ࢙ࢫࢸࣟࣥ㸦P㸲㸧 ... 20 1-2-6, 㓄 ... 21 1-2-7, ༸☜ㄆ ... 21 1-2-8, ዷፎデ᩿ ... 21 1-2-9, ⤫ィᏛⓗゎᯒ ... 21 1-3, ⤖ᯝ ... 22 1-3-1, ࣈࢭࣞࣜࣥᢞࡼࡿ༸⋡ ... 22 1-3-2, ༸ࡲ࡛ࡢ༸⬊ᚄ࠾ࡼࡧᙧ≧ࡢኚ ... 22 1-3-3, ༸ࡲ࡛ࡢᖍ༸⬊࠾ࡼࡧᏊᐑࡢᾋ⭘ീᡤぢࡢ᥎⛣ ... 23 1-3-4, ༸ࡲ࡛ࡢ㛫 ... 24
1-3-5, 㓄ᅇᩘ, ༸⋡, ཷ⫾⋡ ... 24 1-3-6, ෆศἪືែ ... 25 1-4, ⪃ᐹ ... 27 1-5, ᑠᣓ ... 33 㝃㸧ᅗ⾲ ... 35 ➨2 ❶ 㔜㍛㤿㞤㤿࠾ࡅࡿ⬇⬊Ⓨ⫱ኚࡢ≉ᚩ 2-1, ᗎㄽ ... 45 2-2, ヨ㦂ᴫせ ... 47 2-2-1, ౪ヨ㤿 ... 47 2-2-2, ヨ㦂᪉ἲ ... 47 2-2-3, ㉸㡢Ἴ⏬ീ᳨ᰝ ... 47 2-3, ⤖ᯝ ... 48 2-4, ⪃ᐹ ... 50 2-5, ᑠᣓ ... 54 㝃㸧ᅗ⾲ ... 55 ⥲ᣓ ... 61 ㅰ㎡ ... 67 ᩥ⊩ ... 68 Ꮫㄽᩥせ᪨ ... 79 Abstract ... 83
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2 㤿ࡣே㢮࠾࠸࡚᭱ࡶ㔜せ࡞ᐙ␆࡛࠶ࡾ㐣ཤࡽ⌧ᅾࡲ࡛㤿ࡢᚑ㡰ᛶࡸᶵ ᩄᛶࡽே㢮ࡢࡋ࡚ㄆ㆑ࡉࢀ࡚ࡁࡓ>@ ࠋ 㤿ࡣேࡶṔྐࢆṌࢇ࡛ ࡁࡓᐙ␆࡛࠶ࡾ᪥ᮏࡣ㸳ୡ⣖ᚋ༙ࡽ㸴ୡ⣖ࡅ࡚㝣ࡽ㤿ࡢᩥ ࡀఏ࠼ࡽࢀࡓࡉࢀ࡚࠸ࡿ>@ ࠋ ᫂ᮎࡽึᮇࡲ࡛ࡢ᪥ᮏࡣ⣙ 150 㢌ࡢ㤿ࡀ㣫㣴ࡉࢀ࡚࠸ࡓࠋᡓ๓ࡢ㤿ࡢᙺ⏝㏵ࡣ㌷㍺㏦㸦᪑ᐈ ㏻ಙ≀㈨࣭㎰⏘≀࣭⏕⏘㈨ᮦࡢ㐠ᦙ㐀ᮦᦙฟ➼㸧㎰⪔ࡢ3 ࡘࡀせ࡞ ᙺ⏝㏵࡛࠶ࡗࡓࠋ ࡑࡢ୰࠶ࡗ࡚ᾏ㐨ࡣ 㤿⏘ࡢ᭱ࡶ┒ࢇ࡞ᆅᇦࡢ୍ࡘ࡛࠶ ࡾ ⌧ᅾ࠾࠸࡚ࡶᾏ㐨ࡢᅜࢩ࢙ࡣ㍍✀㤿ࡢ 96㸣㎰⏝㤿ࡢ 87㸣 ᅽಽⓗ࡞ࢩ࢙ࢆࡗ࡚࠸ࡿ>@ࠋ ㍍✀㤿ࡣᡓ๓ࡢ㤿ᨻィ⏬ୖࡢᐃ⩏ ࡛ရ✀࡛ࡣࢧࣛࣈࣞࢵࢻ㸦ࢧࣛ⣔㸧ࣛࣈ࣭ࣥࢢࣟࣛࣈ㸦ࣛ⣔㸧 ࡉࢀᡓ๓࡛ࡣ㝣㌷⏝㤿➇㉮㤿ᡓᚋࡣᖹᆅ➇㉮㤿ࡋ࡚ᙺࡉࢀ࡚ ࠸ࡿ㤿࡛࠶ࡿ> @ࠋ ㎰⏝㤿ࡣရ✀ࡢୖ࡛ࡣ㔜✀࣭୰㛫✀ᙺ┠ⓗ࡛ ࡣᡓ๓ࡣ㎰⏝㸦㎰⪔࣭ᙺ㤿࣭㍺㏦㸧ᙺࡉࢀ࡚࠸ࡓࡀ᪥࡛ࡣ⫗⏝ࡤ ࢇ࠼࠸➇㉮⏝ࡋ࡚ᙺࡉࢀࡶࡣࡸ㎰⏝ࡋ࡚㎰⪔➼ᙺࡉࢀ࡚࠸ࡿ㤿ࡣ ⛥࡛࠶ࡿ>@ࠋ ᾏ㐨ࡣ᫂࡞ࡗ࡚࣓ࣜ࢝ࡽすὒ㎰ἲ㸦ࣉࣛ࢘㎰ἲ㸧ࡀ ᑟධࡉࢀᾏ㐨࠾ࡅࡿ㎰⏝㤿ࡢᨵⰋࡣࣉࣛ࢘ࡸࣁ࣮ࣟࢆ≌ᘬࡍࡿࡓࡵࡢ 㤿༉ࡋ࡚ ᆺ࡛ᙉ࠸≌ᘬຊࢆවࡡഛ࠼ࡓ㤿ࡢᨵⰋࡀ⾜ࢃࢀ࡚ࡁ ࡓ >@ࠋ ⤊ᡓᚋࡣ㌷⏝㤿௦ࢃࡾ㎰⪔㤿ࡸ⫗⏝㤿ࡋ࡚ࡢ㟂せࡽࡼࡾ
3 ᆺ࡛ࡼࡾᙉ࠸≌ᘬຊࡀồࡵࡽࢀᾏእࡽ࣌ࣝࢩࣗࣟࣥ✀ࣈࣝࢺࣥ✀ ࣋ࣝࢪࣕࣥ✀࡞ࡢᆺࡢ㤿ࡀ✚ᴟⓗᑟධࡉࢀရ✀ᨵⰋࡀᅗࡽࢀ࡚ࡁࡓ>@ࠋ ᖺጞࡲࡗࡓᾏ㐨ࡢࡤࢇ࠼࠸➇㤿ࡢ㛤ദࡶ㎰⏝㤿ࡢᆺᢿ㌴ࢆ ࡅࡿࡁ࡞せᅉ࡞ࡗࡓ>@㸦)LJ㸧ࠋ᪥ࡢ㔜㍛㤿ࡣ࣌ࣝࢩࣗ ࣟࣥ✀ࣈࣝࢺࣥ✀࣋ࣝࢪࣕࣥ✀ࢆࡅྜࡏࡓ㞧✀࡛࠶ࡾయ㔜ࡀ1 ࢺࣥ ࢆ㉸࠼ࡿୡ⏺᭱⣭ࡢ㤿᪥ᮏ㍛⣔✀ࡋ࡚ㄆ㆑ࡉࢀ࡚࠸ࡿ>@㸦)LJ㸧ࠋ ᪥ᮏ࡛⏝࠸ࡽࢀ࡚࠸ࡿ㤿ࡢ⛠ࡣ㐣ཤᏑᅾࡋࡓᅜࡢᶵ㛵࡛࠶ࡿ㤿ᨻᒁࡢᥦ ၐࡋࡓ㍍✀୰㛫✀㔜✀ᅾ᮶✀ࡢ4 ✀㢮ࡀ࠶ࡿ>@ࠋ ⌧ᅾࡣ⤫ィୖ࡛ࡣ㤿 ࡣࡑࡢᙺ┠ⓗᛂࡌ࡚㍍✀㤿㎰⏝㤿⏝㤿ᅾ᮶㤿⫧⫱㤿༊ศࡉ ࢀ⏕⏘⤫ィࡀሗ࿌ࡉࢀ࡚࠸ࡿ>@ࠋ ᪥ᮏᅜෆࡢ◊✲ㄽᩥ࠾࠸࡚ࡣࠕ㔜✀ࠖ >@࠶ࡿ࠸ࡣࠕ㔜✀㤿ࠖࡉࢀ࡚࠸ࡿࡢࡀ୍⯡ⓗ࡛࠶ࡿࡀᮏ◊✲࠾࠸ ࡚ࡣ▼ࡀᥦၐࡍࡿࠕHeavy draft horsesࠖࡢ᪥ᮏㄒ┤ヂࡢࠕ㔜㍛㤿ࠖ⤫୍ࡋ ࡚⾲グࡍࡿ>@ࠋ ᾏ㐨ദࡢබႠ➇㤿ࠕࡤࢇ࠼࠸➇㤿ࠖࡣ22 ᖺ 24 ᖺࡽᾏ㐨 4 ᕷ 㸦᪫ᕝ࣭ᒾぢἑ࣭ぢ࣭ᖏᗈ㸧࡛㛤ദࡉࢀ࡚ࡁࡓࡀᆅ᪉➇㤿ࡢ⾶㏥ࡽᖹᡂ 19 ᖺ 4 ᭶௨㝆ࡣᖏᗈᕷ༢⊂㛤ദ࡞ࡗࡓ>@ࠋ ࡤࢇ࠼࠸➇㤿ࡣ࡞࠾㔜 ㍛㤿⏕⏘⪅ࡢ㤿⏘ࡢࡁ࡞ࣥࢭࣥࢸࣈࡋ࡚⏕⏘ពḧࢆᨭ࠼ᾏ㐨ࡢ 㤿ᩥࡢ୍ࡘࡋ࡚ࠕᾏ㐨㑇⏘ࠖࡶ㑅ᐃࡉࢀ࡚࠸ࡿࠋ ୍᪉࡛ࡣ㸪㤿⫗㸦㤿
4 ่ࡋ㸧ࡢ㟂せࡢ㧗ࡲࡾࡶ㸪㔜㍛㤿ࢆྵࡵࡓ⫗⏝㤿ࡢᾘ㈝⪅ࢽ࣮ࢬࡶ㧗ࡲ ࡗ࡚ࡁ࡚࠸ࡿࡀᅜෆ⏕⏘࡛ࡣࡃ㊊ࡋ࡚࠾ࡾᅜෆ㟂せࢆ‶ࡓࡍࡓࡵᅜ ෆ⏕⏘㢌ᩘࡢ2 ಸ௨ୖࡢ㤿ࡀ࢝ࢼࢲࡽ⏕య㍺ධࡉࢀᅜෆ࡛⫧⫱ࡉࢀࡓᚋ ᅜ⏘㧗⣭㤿⫗㸦㤿่ࡋ㸧ࡋ࡚ὶ㏻ࡋ࡚࠸ࡿ⌧≧ࡀ࠶ࡿ>@ 㸦)LJ㸧ࠋ ᪥ ᮏ࡛ࡣ㤿ࡢ㣗⏝ᩥ㛵ࡋ࡚ࡣᆅᇦᛶ㸦ᕞ, 㝣, ᮾ㸧㸦)LJ㸧ࡀ࠶ࡿ ࡀ₯ᅾⓗ࡞⫗⏝㤿ࡋ࡚ࡢ㟂せࡣ㧗ࡃຠ⋡ⓗ࡛Ᏻᐃⓗ࡞㔜㍛㤿⏕⏘ࡀồࡵࡽ ࢀ࡚࠸ࡿࠋࡋࡋ㸪₯ᅾⓗ㟂せࡢ㧗ࡲࡾࡣ㏫㸪㏆ᖺࡢ㔜㍛㤿ࡢ⏕⏘㢌ᩘࡣ ᖹᡂ6 ᖺࡢ⣙ 8,097 㢌ࢆࣆ࣮ࢡᖹᡂ 27 ᖺࡢ 1,101 㢌ࡲ࡛ῶᑡࡋࡤࢇ࠼࠸ ➇㤿Ⓩ㘓㢌ᩘࡶ55 ᖺࡢ 1,394 㢌ࡽᖹᡂ 27 ᖺࡣ 716 㢌ࡲ࡛ῶᑡࡋࡓ⌧ ᐇࡀ࠶ࡿ>@ࠋ ✀ࡅ㞤㤿㢌ᩘᑐࡍࡿฟ⏕Ꮚ㤿㢌ᩘࡢẚ⋡㸦⏕⏘⋡㸧ࡣᖹᡂ ᖺࡢ 㸣ࢆࣆ࣮ࢡ⦾Ṫ㞤㤿㣫㣴㢌ᩘࡢῶᑡక࠸పୗࡋᖹᡂ ᖺࡣ 㸣㸳ࢆୗᅇࡿࡲ࡛పୗࡋ࡚࠸ࡿ>@ 㸦)LJ㸧ࠋ 㔜㍛㤿⏕⏘⌧ሙࡢ⫼ᬒࡋ࡚㣫㣴㢌ᩘࡢῶᑡక࠸␆⏘㛵ಀᶵ㛵ࡢ㤿ᑓ 㛛ᢸᙜ⪅ࡢῶᑡᚋ⥅⪅ᅾࡼࡿ⟶⌮⪅ࡢ㧗ᖺ㱋⫧⫱㤿ࡢᕷሙ౯᱁ࡢኚ ືࡀࡁࡃ㔜㍛㤿ᑓᴗ࡛ࡣ␆⏘ᴗࡋ࡚ࡢ⤒Ⴀࡀᅔ㞴࡛ᴗ㊃ⓗ࡞⤒Ⴀ య⣔ࡀከᩘࢆ༨ࡵ࡚࠸ࡿ⌧≧ࡀ࠶ࡿࠋࡲࡓ㣫㣴㢌ᩘࡢῶᑡక࠸⋇་ᖌ ࡀ✚ᴟⓗ⦾Ṫ⟶⌮᥋ࡍࡿᶵࡶῶᑡࡋ⋇་Ꮫⓗ࡞ᑐᛂ⟇ࡀ༑ศⓎࡉ ࢀࡎಶయ౯᱁ࡢኚື➼ࡢ⤒῭ⓗ⏤ࡶ㛵ࢃࡾ⏕⏘⪅ࡸ✀㤿⟶⌮⪅ࡢ⤒㦂
5 ᇶ࡙࠸ࡓ㠀ຠ⋡ⓗ࡞⦾Ṫ⟶⌮ࡀ⾜ࢃࢀ࡚࠸ࡿࠋࡉࡽᑡᩘࡢ✀㤿ࡀヨ 㤿ࡶවࡡ⦾Ṫࢩ࣮ࢬࣥᮇ㛫୰ࡣ㛗㊥㞳㍺㏦㢖ᅇ✀ࡅࡼࡿࢫࢺࣞࢫࡼ ࡿ⢭ᾮᛶ≧ࡢᝏᙳ㡪ࡸ⾨⏕ⓗ࡞ᑐᛂࡀ࡞≧ែ࡛ࡢ㢖ᅇ㓄ࡀ⾜ࢃࢀ 㓄ㄏᑟᛶᏊᐑෆ⭷⅖ࡢࣜࢫࢡࡶ㧗ࡲࡗ࡚ࡁ࡚࠸ࡿࠋࡇࡢࡼ࠺࡞⫼ᬒࡀ㔜㍛ 㤿ࡢ⏕⏘ຠ⋡పୗࡢࡁ࡞せᅉ࡞ࡗ࡚࠸ࡿࡇࡀᐃࡉࢀࡿࠋ㍍✀㤿ࡢ⦾Ṫ ⏕⌮㛵ࡍࡿ◊✲ࡣ㐍ࢇ࡛࠸ࡿࡀ㔜㍛㤿ࡢ≉␗࡞⦾Ṫ⏕⌮ࡣ᫂ࡽࡉࢀ࡚ ࠸࡞࠸ࠋࡑࡇ࡛➨ ❶࡛ࡣ㔜㍛㤿ࡢ⏕⏘ຠ⋡ࢆྥୖࡉࡏࡿࡓࡵࡑࡢ⦾ Ṫ≉ᛶࢆ᫂ࡽࡋ ᖺ ⏘ࢆ┠ᣦࡋࡓ⏕⏘ຠ⋡ࢆ⥔ᣢࡍࡿࡓࡵࡢᑐᛂ⟇ࢆ ᳨ウࡋࡓࠋ㔜㍛㤿ࡢⓎᮇࡢ༸ᕢ࠾ࡼࡧᏊᐑࡢᙧែⓗኚࢆ㉸㡢Ἴ⏬ീ᳨ᰝ ࡚⤒ⓗほᐹࡋ༸๓ᚋࡢᖍ༸⬊Ꮚᐑࡢᙧែⓗ≉ᚩࢆ᫂ࡽࡍࡿࡇ ࡼࡗ࡚㔜㍛㤿㞤㤿ࡢ㐺ษ࡞㓄㐺ᮇࡢᣦᶆࢆ᳨ウࡋࡓࠋࡲࡓ㔜㍛㤿 ࠾ࡅࡿ᭷ຠ࡞༸ࡢྠᮇἲࢆ☜❧ࡍࡿࡓࡵ㔜㍛㤿㞤㤿ࡢ༸ㄏ㉳ࢆ┠ⓗ ࡋࡓ*Q5+ 㢮ఝయࣈࢭࣞࣜࣥ༢ᅇᢞࡘ࠸࡚ࡑࡢຠᯝෆศἪືែࡢ ᙳ㡪ࢆㄪᰝࡋࡓࠋᮇ㛫ࡀ㝈ᐃࡉࢀࡓ⦾ṪᏘ⠇ຠ⋡ⓗ࡞⦾Ṫ⟶⌮ࢆ⾜࠺ୖ࡛ 㤿ࡣ᪩ᮇ⬇Ṛ⁛ࡢⓎ⏕⋡ࡀ㧗ࡃ>@᪩ᮇࡢዷፎデ᩿⬇⬊ࡢⓎ⫱ࢫ ࢸ࣮ࢪᛂࡌࡓⓗ☜࡞ዷፎデ᩿ࡀせồࡉࢀࡿࠋࡋࡋ㔜㍛㤿ࡢዷፎࢫࢸ࣮ࢪ ࠾ࡅࡿ⬇⬊Ⓨ⫱ࡢᙧែⓗ≉ᚩࡢሗ࿌ࡣࡉࢀ࡚࠸࡞࠸ࠋࡑࡇ࡛➨ ❶࡛ࡣ ㉸㡢Ἴ⏬ീデ᩿⨨ࢆ⏝࠸࡚㔜㍛㤿ࡢ⬇⬊ࡢⓎ⫱ኚࡢ≉ᚩࢆ᫂ࡽࡋዷ
6 ፎデ᩿ࡢࡓࡵࡢᶆ‽ീࡢ᳨ウゐデ࡛ࡣண ࡀᅔ㞴࡞ᮇࡽ⫾㱋ண ࡢྍ ⬟ᛶࡢ᳨ウ࠾ࡼࡧ᪩ᮇ⬇Ṛ⁛ࡸ␗ᖖ࡞⬇Ⓨ⫱ࢆ᪩ᮇⓎぢࡋࡑࢀࡽࡢ㚷ูデ ᩿ࡢ᰿ᣐࢆ᫂☜ࡍࡿࡇࢆ┠ⓗࡋࡓࠋ 㔜㍛㤿ࡢ⏕⏘య⣔ࡣ⫗⏝㤿ࡋ࡚ࡣ⫗∵⏕⏘ྠᵝ࡞ຠ⋡ⓗ࡞⦾Ṫ⟶⌮ᢏ ⾡ࡀồࡵࡽࢀࡿࠋ㔜㍛㤿ࡢ᫂ࡽࡉࢀ࡚࠸࡞࠸⦾Ṫ≉ᛶࢆ᫂ࡽࡋࡤࢇ ࠼࠸➇㉮㤿⫗⏝㤿ᙺ㤿ࡋ࡚ࡢ୕㠃ᛶࢆᣢࡘ㔜㍛㤿ࡢ⏕⏘యไࢆ⋇་ Ꮫⓗ࡞ᑐᛂ⟇ࢆ㏻ࡋ࡚ᡃࡀᅜ≉᭷ࡢ㤿⏕⏘⏘ᴗࡋ࡚☜❧ࡋࡓ࠸⪃࠼ࡓࠋ
7
㝃㸧ᅗ⾲
Fig. 0-1. Heavy draft horses running in Ban’ei horse rase.
8
Fig. 0-2. Japanese heavy draft mares.
The Japanese heavy draft mares is acknowledged as the largest horse
in the world, weighing an average of approximately a ton.
9
Fig. 0-3. Import number of beef horses from Canada.
10
Fig. 0-4. The number of slaughter horses in 2014.
(Cited from Ministry of Agriculture, Forestry and Fisheries.)
11
Fig. 0-5. Change in the number of breeding head of heavy draft mares
and the number of birth rate of foals.
12
➨
1 ❶
㔜㍛㤿㞤㤿࠾ࡅࡿ㓄㐺ᮇࡢᣦᶆ
࠾ࡼࡧ
GnRH 㢮ఝయࣈࢭࣞࣜࣥ༢ᅇᢞࡀ༸ྠᮇ
ෆศἪືែཬࡰࡍᙳ㡪
13 ᗎㄽ 㔜㍛㤿ࡣዷፎᮇ㛫ࡀ 㹼 ᪥㛗ࡃ>@㛗᪥ᛶࡢᏘ⠇⦾Ṫື≀࡛࠶ࡿࡓ ࡵ㓄ᮇࡀ㝈ᐃࡉࢀࡿࠋ㔜㍛㤿ࡢせ࡞⏕⏘ᆅ࡛࠶ࡿᾏ㐨༑ࡢ㓄ᮇ ࡣ 㹼 ᭶㝈ᐃࡉࢀཷ⫾ࡢᡂྰࡼࡾ㔜㍛㤿ࡢ⏕⏘ᛶࡣࡁࡃᕥྑࡉࢀࡿࠋ ຠ⋡ⓗ࡞㔜㍛㤿⏕⏘ࡢࡓࡵ୍Ⓨ୍ᅇࡢ㓄ࡲࡓࡣ⾨⏕ⓗ࡞ேᕤᤵ⢭ ࡼࡿཷ⫾ࡀᮃࡲࡋ࠸ࡉࢀ࡚࠸ࡿࠋࡑࡢࡓࡵࡣ㓄㐺ᮇࡢྠᮇࡀຠᯝⓗ ࡛࠶ࡿࡀ㔜㍛㤿㞤㤿ࡢⓎᮇࡢᖍ༸⬊࠾ࡼࡧᏊᐑࡢᙧែⓗ≉ᚩࡘ࠸࡚ࡢ ሗ࿌ࡣ࡞ࡃຠᯝⓗ࡞༸ࡢྠᮇ㛵ࡍࡿ◊✲ሗ࿌ࡣᑡ࡞࠸ࠋ ୍⯡ⓗ㍍✀㤿ࡢ༸ㄏ㉳ࡣࣄࢺ⤧ẟᛶࢦࢼࢻࢺࣟࣆࣥ K&* ࡀ⏝࠸ࡽ ࢀ࡚࠸ࡿࠋ┤ᚄ PP ௨ୖࡢ༸⬊ᑐࡋ࡚ K&*㹼,8 ᢞࡋ 㹼 㛫 ௨ ෆ ༸ ࡀ 㞟 ୰ ࡍ ࡿ 㧗 ࠸ ༸ ㄏ ㉳ ຠ ᯝ ࡀ ሗ ࿌ ࡉ ࢀ ࡚ ࠸ ࡿ >@ࠋK&* ࡣᏳ౯࡛㧗࠸༸ㄏ㉳ຠᯝࢆ♧ࡍ㠃⾑୰༙ῶ ᮇࡀ 㹼 㛫㛗ࡃ」ᩘ༸ࡼࡿ⫾ዷፎࡢࣜࢫࢡ>@ࡸᢠయ⏘⏕ ࡼࡿᛂᛶࡢపୗࡀᣦࡉࢀ࡚࠸ࡿ>@ࠋࡑࡇ࡛*Q5+ 㢮ఝయࢹࢫࣟࣞ ࣜࣥࣥࣉࣛࣥࢺ〇㸦2YXSODQW70㸧ࡼࡿຠᯝⓗ࡞༸ㄏ㉳ࡀヨࡳࡽࢀ࡚࠸ ࡿ> @ࠋࡋࡋࣥࣉࣛࣥࢺ〇ࡢ㐺ᛂࡣཷ⫾ࡢሙྜୗᆶయᛶ ࢲ࢘ࣥࣞࢠ࣮ࣗࣞࢩࣙࣥࡼࡿⓎఇṆᮇࡸ༸㛫㝸ࡢᘏ㛗ࡀᣦࡉࢀ༸ ☜ㄆᚋࣥࣉࣛࣥࢺ〇ࢆ㝖ཤࡍࡿࡇࡀ᥎ዡࡉࢀ࡚࠸ࡿ> @ࠋࡲࡓ᪥
14 ᮏ࡛ࡣࣥࣉࣛࣥࢺ〇ࡣㄆྍࡉࢀ࡚࠸࡞࠸ࠋࡑࡇ࡛*Q5+ 㢮ఝయࣈࢭࣞࣜ ࣥ㸦௨ᚋࣈࢭࣞࣜࣥ㸧ࡼࡿ༸ㄏ㉳ࡀヨࡳࡽࢀ>@ࣈࢭࣞࣜࣥ༢ ᅇᢞࡼࡿ༸ㄏ㉳ຠᯝࡢሗ࿌ࡀ࠶ࡿ>@ࠋ୍᪉࡛ࣈࢭࣞࣜࣥ༢ᅇᢞ ࡣ/+ ࡢ୍㐣ᛶࡢୖ᪼ࢆ♧ࡍࡀ /+ ࢧ࣮ࢪࡢᣢ⥆ࡣ༑ศ࡛࠶ࡿࡢሗ࿌ࡶ ࠶ࡿ> @ࠋࡇࡢࡓࡵࣈࢭࣞࣜࣥ ȣ㹥ࢆ 㛫㛫㝸࡛ 㹼 ᅇ ᢞࡼࡗ࡚༸ࡲ࡛ࡢ㛫ࡢ▷⦰ࡀㄆࡵࡽࢀࡓሗ࿌㹙㹛ࡸࣈࢭࣞࣜ ࣥ ȣ㹥㐃⥆ᢞࡼࡿ༸ㄏ㉳ຠᯝࡢሗ࿌㹙㹛ࡀ࠶ࡿࠋ㍍✀㤿ࡣಶయ ౯್ᙺ┠ⓗࡀࡁࡃ␗࡞ࡿ㔜㍛㤿ࡢ⏕⏘⌧ሙ࡛ࡣ↹㞧ᛶ⤒῭ⓗ⌮⏤ ࡽࡇࡢࡼ࠺࡞༸ྠᮇࡣ୍⯡ⓗ࡛ࡣ࡞ࡃᬑཬࡍࡿྍ⬟ᛶࡣప࠸ࠋࡑࡇ࡛ᮏ ❶࡛ࡣ㉸㡢Ἴ⏬ീ᳨ᰝࡼࡿ㔜㍛㤿㞤㤿ࡢⓎᮇࡢ༸ᕢ㸦༸⬊㸧Ꮚᐑࡢᙧ ែⓗኚࢆ᫂ࡽࡋ༸ᮇண ࡢデ᩿᰿ᣐ㐺ษ࡞㓄㐺ᮇࡢᣦᶆࢆ♧ ࡍඹ⤒῭ⓗ࡞༸ࡢྠᮇࢆ┠ⓗࡋࡓࣈࢭࣞࣜࣥࡢ༢ᅇᢞࡼࡿ ༸ㄏ㉳ຠᯝෆศἪືែࡘ࠸࡚ㄪᰝࡍࡿࡇࢆ┠ⓗࡋࡓࠋ
15 ヨ㦂ᴫせ ౪ヨ㤿 ࣈࢭࣞࣜࣥᢞ㔞ࡢ᳨ウࡣᾏ㐨ᖏᗈᕷෆ㸱㎰ሙ࡛㣫㣴ࡉࢀ࡚࠸ࡿṇᖖ ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿᮍ⤒⏘ࡽ⤒⏘㸦㹼 ṓ㸧ࡢ㔜㍛㤿㞤㤿ࡢ 㢌 ࢆ⏝࠸ࡓࠋ ෆศἪືែࡢほᐹⓎᮇࡽ༸ᚋࡲ࡛ࡢ༸ᕢ㸦༸⬊㸧Ꮚᐑࡢ㉸㡢Ἴ ⏬ീ᳨ᰝࡼࡿᙧែⓗ≉ᚩࡢほᐹࡣᾏ㐨ᖏᗈᕷෆ㸯㎰ሙ࡛㣫㣴ࡉࢀ࡚࠸ࡿ ṇᖖ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿᮍ⤒⏘ࡽ␗࡞ࡿ⏘ḟᩘࡢ㔜㍛㤿㞤㤿 㢌ࡢ 㢌ࢆ⏝࠸ࡓࠋ౪ヨ㤿ࡢᖺ㱋ࡣ 㹼 ṓᖹᆒ s 6' ṓ⏘ḟᩘࡣ 㹼 ⏘㸦ᮍ⤒⏘ 㢌⤒⏘ 㢌㸧ᖹᆒ s 6' ⏘࡛࠶ࡗࡓࠋ ࣈࢭࣞࣜࣥᢞ㔞ࡢ᳨ウ 㐃⥆ࡍࡿ ⦾Ṫࢩ࣮ࢬࣥࡢ 㹼 ᭶ṇᖖ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿ㔜㍛㤿㞤㤿 ࡢ 㢌ᑐࡋ࡚ヨ㤿ࡼࡿⓎᚩೃࢆ♧ࡋ 㹼 ᪥㛫ࡢ⤒┤⭠㉸㡢Ἴ᳨ ᰝ࡚┤ᚄPP ௨ୖࡢᖍ༸⬊ࡀㄆࡵࡽࢀࡓࣈࢭࣞࣜࣥ>࢚ࢫࢺ࣐࣮ࣝ ὀᕝᓮ୕㮚〇⸆ ᰴ ᮾி@ȣJ㸦Q 㸧࠶ࡿ࠸ࡣ ȣJ㸦Q 㸧ࢆ㢁㒊 ➽⫗ෆᢞࡋྠᵝࡢ᮲௳࡛ほᐹࡋࡓ↓ฎ⨨⩌㸦Q 㸧ࡢ 㛫௨ෆࡢ༸ ⋡ࡢẚ㍑᳨ウࢆ⾜ࡗࡓࠋ
16 ヨ㦂᪉ἲ ࣈࢭࣞࣜࣥᢞ㔞ࡢ᳨ウ⤖ᯝࡼࡾࣈࢭࣞࣜࣥᢞ㔞ࢆ ȣJ タᐃࡋ㉸㡢 Ἴ⏬ീ᳨ᰝࡼࡿⓎᮇࡢ༸ᕢ㸦༸⬊㸧Ꮚᐑࡢᙧែⓗኚࢆ᫂ࡽࡋෆ ศἪᏛⓗ᳨⣴ࢆ┠ⓗࡋ࡚ヨ㦂ࢆᐇࡋࡓࠋࡲࡓྠࣈࢭࣞࣜࣥ ȣJ ༢ ᅇᢞࡼࡿ༸ㄏ㉳ຠᯝࢆ᳨ドࡋࡓࠋ 㐃⥆ࡍࡿ ⦾Ṫࢩ࣮ࢬࣥࡢ 㹼 ᭶ᾏ㐨ᖏᗈᕷෆ㸯㎰ሙ㣫㣴ࡉࢀṇᖖ ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿᮍ⤒⏘ࡽ␗࡞ࡿ⏘ḟᩘࡢ㔜㍛㤿㞤㤿 㢌ࡢ 㢌ࢆ ౪ヨࡋࡓࠋヨ㤿ࡼࡿⓎᚩೃࢆ♧ࡋ┤ᚄPP ௨ୖࡢᖍ༸⬊ࡀ☜ㄆࡉࢀ ๓᪥ࡢ᳨ᰝグ㘓ẚᏊᐑᾋ⭘ീࡢῶᑡࡀほᐹࡉࢀࡓࣈࢭࣞࣜࣥ ȣJ ࢆ㢁㒊➽⫗ෆᢞࡋࡓᢞ⩌㸦Q 㸧ྠᵝࡢ᮲௳࡛ࡢほᐹ↓ฎ⨨࡛ ༸ࡲ࡛ほᐹࡋࡓᑐ↷⩌ Q ࠾࠸࡚ヨ㦂ࢆ⾜ࡗࡓࠋᑐ↷⩌ࡢ ࡣศፔᚋ ᪥ࡑࡢࡢ㸦 㢌㸧ࡣศፔᚋ ᪥௨㝆ࡢほᐹ࠾ࡼࡧ✵⫾㤿㸦 㢌㸧 ࠾ࡅࡿⓎ࡛ほᐹࢆ⾜ࡗࡓࠋᢞヨ㦂ࡣ⥲Ⓨ࿘ᮇᩘࢆᇶᢞ⩌ᑐ↷ ⩌ࢆࢡࣟࢫ࣮࢜ࣂ࣮ࢹࢨࣥࡼࡾヨ㦂ࢆᐇࡋࡓࠋ ᢞ⩌ࡣᢞᚋ༸☜ㄆࡲ࡛ 㛫㛫㝸༸ᚋࡣ 㛫ࡲ࡛ 㛫㛫 㝸࡛༸⬊㸦༸ᕢ㸧Ꮚᐑࡢ⤒┤⭠㉸㡢Ἴ᳨ᰝࢆ⾜ࡗࡓࠋᑐ↷⩌ࡣ༸☜ㄆᚋ ᪥ࡲ࡛ ᪥㛫㝸࡛ྠᵝ༸⬊㸦༸ᕢ㸧Ꮚᐑࡢほᐹࢆ⾜ࡗࡓ㸦)LJ㸧ࠋ༸ ⬊࠾ࡼࡧᏊᐑࡢᙧែࡣ⤒┤⭠࡚㉸㡢Ἴデ᩿⨨>66'ࣟ࢝ᮾி@ 0+] ࣜࢽᆺ┤⭠᳨ᰝ⏝᥈ゐᏊ>867ࣟ࢝ᮾி@ࢆ᥋⥆ࡋ᳨࡚⣴ࡋ
17 ࡓࠋᥥฟࡉࢀࡓ༸⬊㟼Ṇ⏬ീࡽ௵ពࡢ㸦㛗ᚄ㸩▷ᚄ㸧 ࢆ༸⬊ᚄࡋ࡚ィ ࡋࡓ㸦)LJ㸧ࠋ ᥇⾑ ୧⩌ࡶ㉸㡢Ἴ᳨ᰝ㝿ࡋ࣊ࣃࣜࣥࢼࢺ࣒ࣜ࢘ຍ┿✵᥇⾑⟶㸦Venoject II VP-H100K㸪ࢸࣝࣔ㸦ᰴ㸧㸪ᮾி㸧࠾ࡼࡧ᥇⾑㔪㸦21 G × 1 1/2” needle MN-2138MS㸪 ࢸࣝࣔ㸦ᰴ㸧㸪ᮾி㸧ࢆ⏝࠸࡚㢁㟼⬦ࡼࡾ᥇⾑ࡋࡓࠋ ᥇ྲྀࡋࡓ⾑ᾮࡣࡍࡳࡸ ị෭ࡋ㸪2 㛫௨ෆ㐲ᚰศ㞳ࡋ㸦12 ศ㸪1,000g㸧㸪⾑₢ࢆ᥇ྲྀࡋࡓࠋ ᥇ ྲྀࡋࡓ⾑₢ࡣ㸪࣍ࣝࣔࣥ⃰ᗘ ᐃࡲ࡛㸫 Υ ࡛෭ಖᏑࡋࡓࠋ ෆศἪືែࡢほᐹ 㯤యᙧᡂ࣍ࣝࣔࣥ㸦LH㸧㸪༸⬊่⃭࣍ࣝࣔࣥ㸦FSH㸧ࡣᮾி㎰ᕤᏛᐙ␆⏕ ⌮Ꮫ◊✲ᐊ࠾࠸࡚ᢠయRIA ἲࢆ⏝࠸࡚ᐃ㔞ࢆ⾜ࡗࡓࠋ ࢚ࢫࢺࣛࢪ࣮࢜ࣝ -17ș㸦E㸰㸧㸪ࣉࣟࢪ࢙ࢫࢸࣟࣥ㸦P㸲㸧ࡣᖏᗈ␆⏘Ꮫᐙ␆⏕⏘⾨⏕Ꮫㅮᗙᐑᮏ ᫂ኵ◊✲ᐊ࠾࠸࡚ᢠయEIA ἲࢆ⏝࠸࡚ᐃ㔞ࢆ⾜ࡗࡓࠋ 㯤యᙧᡂ࣍ࣝࣔࣥ㸦LH㸧 ⾑୰/+⃰ᗘࡢ ᐃࡣ+DPDGDࡽࡢ᪉ἲ㹙㹛‽ࡌࡓᢠయ5,$ἲࢆ⏝࠸ࡓࠋᶆ ‽ᾮࡋ࡚࢘ࢩ/+㸦86'$E/+%㸧ࢆ⏝࠸ࡓࠋ%6$03%6 S+ ࡛ᕼ 㔘⣔ิࢆస〇ࡋ㸪ȣOࡎࡘ࢞ࣛࢫヨ㦂⟶ศὀࡋ㸪%6$03%6ࢆȣO
18 ຍ࠼㔞ࢆȣOࡋࡓࠋྠᵝヨ㦂⾑₢ȣO%6$03%6ȣOࢆຍ ࠼㔞ࢆȣOࡋࡓࠋḟ➨ᢠయࡋ࡚ᢠࣄࢺ/+࢘ࢧࢠ⾑Ύ㸦<0㸧ࢆ ⏝࠸㸪ࡑࢀࢆ15603%6 S+ ࡛ಸᕼ㔘ࡋ㸪ྛヨ㦂⟶ȣOࡎ ࡘศὀࡋ㸪᩿⥆ศ㛫᧠ᢾᚋ㸪Υ࡚㛫ᛂࡉࡏࡓࠋḟ࣐࢘/+ࡢ{tͶ,ᶆ ㆑ᢠཎ㸦ᮾி㎰ᕤᏛ⏕⌮Ꮫ◊✲ᐊᥦ౪㸧ࢆ%6$03%6࡛FSPㄪᩚࡋ ࡓࡶࡢࢆȣOࡎࡘศὀࡋ᩿⥆㛫᧠ᢾᚋ㸪Υ࡛㛫ᛂࡉࡏࡓࠋ᭦➨ ᢠయࡋ࡚ᢠ࢘ࢧࢠȚࢢࣟࣈࣜࣥࣖࢠ⾑ΎࢆȣO࡙ࡘศὀࡋ࡚㸪᩿⥆ᅇ᧠ᢾ ᚋΥ࡚㛫ᛂࡉࡏࡓࠋ࡞࠾ᢠ࢘ࢧࢠȚࢢࣟࣈࣜࣥࣖࢠ⾑Ύࡣ࣏࢚ࣜࢳ ࣞࣥࢢࣜࢥ࣮ࣝ03%6 S+ ࡛ಸᕼ㔘ࡋࡓࡶࡢࢆ⏝ࡋࡓࠋᛂᚋΥ ࡚Jศ࡛ศ㛫㐲ᚰᚋୖΎࢆᤞ࡚࡚ỿ´ࡢᨺᑕάᛶࢆȚ࢝࢘ࣥࢱ࣮࡛ ᐃࡋࡓࠋ ᐃෆኚືಀᩘࡣ 㸣࡛࠶ࡗࡓࠋࡲࡓ᭱ᑠ᳨ฟ⃰ᗘࡣQJPO࡛࠶ࡗ ࡓࠋ ༸⬊่⃭࣍ࣝࣔࣥ㸦FSH㸧 ⾑୰)6+⃰ᗘࡢ ᐃࡣ+DPDGDࡽࡢ᪉ἲ㹙㹛‽ࡌࡓᢠయ5,$ἲࢆ⏝࠸ࡓࠋᶆ ‽ᾮࡋ࡚࢘ࢩ)6+㸦86'$E)6+,㸧ࢆ⏝࠸ࡓࠋ*HUDWLQ03%6࡛ᕼ 㔘⣔ิ㸦QJȣO㸧ࢆస〇ࡋ㸪ȣOࡎࡘ࢞ࣛࢫヨ㦂⟶ศὀࡋ㸪ࡑࢀ
19 *HUDWLQ03%6ࢆȣOຍ࠼㸪㔞ࢆȣOࡋࡓࠋྠᵝヨ㦂⾑₢ ࠾ࡼࡧ⾑ΎȣO*HUDWLQ03%6ȣOࢆຍ࠼㸪㔞ࢆȣOࡋࡓࠋ ḟ➨ᢠయࡋ࡚ᢠࣄࢺ)6+࢘ࢧࢠ⾑Ύ㸦0 (QGRFULQH6HUYLFH/LPLWHG %HOO&RXUW +LJK6WUHHW%LGRIRUGRQ$YRQ:DUZLFNVKLUH%%*8.㸧ࢆ 1560('7$3%6 S+ ࡛ಸᕼ㔘ࡋ㸪ྛヨ㦂⟶ȣOࡎࡘศ ὀࡋ㸪᩿⥆ศ㛫᧠ᢾᚋ㸪Υ࡚㛫ᛂࡉࡏࡓࠋḟ%6$03%6࡛ FSPㄪᩚࡉࢀࡓ࣐࢘)6+ࡢ{tͶ,ᶆ㆑ᢠཎ㸦ᮾி㎰ᕤᏛ⏕⌮Ꮫ◊✲ᐊᥦ౪㸧 ࢆȣOࡎࡘศὀࡋ㸪᩿⥆㛫᧠ᢾᚋΥ࡛㛫ᛂࡉࡏࡓࠋ᭦➨ᢠయ ࡋ࡚ᢠ࢘ࢧࢠȚࢢࣟࣈࣜࣥࣖࢠ⾑ΎࢆȣO࡙ࡘศὀࡋ࡚㸪᩿⥆ᅇ᧠ᢾᚋΥ ࡚㛫ᛂࡉࡏࡓࠋ࡞࠾㸪ᢠ࢘ࢧࢠȚࢢࣟࣈࣜࣥࣖࢠ⾑Ύࡣ࣏࢚ࣜࢳࣞࣥ ࢢࣜࢥ࣮ࣝ03%6 S+ ࡛ಸᕼ㔘ࡋࡓࡶࡢࢆ⏝ࡋࡓࠋᛂᚋΥ ࡚*ศ࡛ศ㛫㐲ᚰᚋ㸪ୖΎࢆᤞ࡚࡚ỿ´ࡢᨺᑕάᛶࢆȚ࢝࢘ࣥࢱ࣮࡛ ᐃࡋࡓࠋ ᐃෆኚືಀᩘࡣ㸣࡛࠶ࡗࡓࠋࡲࡓ㸪᭱ᑠ᳨ฟ⃰ᗘࡣQJPO࡛࠶ ࡗࡓࠋ ࢚ࢫࢺࣛࢪ࣮࢜ࣝ-17ș㸦E㸰㸧 ⾑ ₢ ୰ (ࢆ ᢳ ฟ ࡍ ࡿ ࡓ ࡵ 㸪⾑ Ύ PO ࢪ ࢚ ࢳ ࣝ ࢚ ࣮ ࢸ ࣝ PO ࢆ ຍ ࠼ 㸪 ศ 㛫 ᧠ ᢾ ࡋ ࡓ ࠋ ᧠ ᢾ ᚋ 㸪ᐊ ศ 㛫 㟼 ⨨ ࡋ ࡓ ᚋ 㸪㸫 Υ
20 ࡢ ෭ ᗜ ⛣ ື ࡋ ⤖ ࡉ ࡏ ࡓ ࠋ ࡑ ࡢ ᚋ 㸪ࡑ ࡢ ୖ ࡳ 㒊 ศ ࡢ ᾮ ࢆ PO ヨ 㦂 ⟶ ⛣ ࡋ 㸪ࢻ ࣛ ࣇ ࢺ ෆ ࡛ ࢘ ࢛ ࣮ ࢱ ࣮ ࣂ ࢫ ෆ ࡢ ᾐ ࡋ 㸪 Ỉ ࢆ 㹼 Υ ୖ ᪼ ࡉ ࡏ ࡞ ࡀ ࡽ 㸪ࢪ ࢚ ࢳ ࣝ ࢚ ࣮ ࢸ ࣝ ࢆ Ⓨ ࡉ ࡏ ࡓ ࠋ Ⓨ ᚋ 㸪(⏝ ࡢ DVVD\EXIIHU ࢆ ȣ PO ຍ ࠼ 㸪ࡼ ࡃ ᧠ ᢾ ࡋ ࡓ ᚋ 㸪 ᢠ య ἲ (Q]\PHLPPXQRDVVD\ (,$ ࢆ ⏝ ࠸ ࡚ ᐃ ࡋ ࡓ ࠋ ࡇ ࡢ ᢳ ฟ ἲ ࡼ ࡿ (ࡢ ᅇ ⋡ ࡣ ࡛ ࠶ ࡗ ࡓ ࠋ ࡲ ࡓ 㸪(ࡢ (,$ ᶆ ‽ ᭤ ⥺ ࡣ 㹼 SJPO ࡢ ⠊ ᅖ ࡛ 㸪(' ࡣ SJPO 㸪 ᐃ ෆ ኚ ື ࠾ ࡼ ࡧ ᐃ 㛫 ኚ ື ࡣ ࡑ ࢀ ࡒ ࢀ ࠾ ࡼ ࡧ ࡛ ࠶ ࡗ ࡓ ࠋ ࣉࣟࢪ࢙ࢫࢸࣟࣥ㸦P㸲㸧 ⾑ Ύ ୰ 3ࢆ ᢳ ฟ ࡍ ࡿ ࡓ ࡵ 㸪⾑ ₢ ȣ PO ࢪ ࢚ ࢳ ࣝ ࢚ ࣮ ࢸ ࣝ PO ࢆ ຍ ࠼ 㸪 ศ 㛫 ᧠ ᢾ ࡋ ࡓ ࠋ ᧠ ᢾ ᚋ 㸪ᐊ ศ 㛫 㟼 ⨨ ࡋ ࡓ ᚋ 㸪( ྠ ᵝ ࡢ ᪉ ἲ ࡛ ⤖ 㸪 Ⓨ ࢆ ࡉ ࡏ ࡓ ࠋ Ⓨ ᚋ 㸪ヨ 㦂 ⟶ ࢆ ෭ ༷ ࡋ ࡚ ࡽ 3⏝ ࡢ DVVD\EXIIHU ࢆ ȣ PO ຍ ࠼ 㸪ࡼ ࡃ ᧠ ᢾ ࡋ ࡓ ᚋ 㸪(,$ ἲ ࢆ ⏝ ࠸ ࡚ ᐃ ࡋ ࡓ ࠋ ࡇ ࡢ ᢳ ฟ ἲ ࡼ ࡿ 3ࡢ ᅇ ⋡ ࡣ ࡛ ࠶ ࡗ ࡓ ࠋ ࡲ ࡓ 㸪 3ࡢ (,$ ᶆ ‽ ᭤ ⥺ ࡣ 㹼 QJPO ࡢ ⠊ ᅖ ࡛ 㸪(' ࡣ QJPO 㸪 ᐃ ෆ ኚ ື ࠾ ࡼ ࡧ ᐃ 㛫 ኚ ື ࡣ ࡑ ࢀ ࡒ ࢀ ࠾ ࡼ ࡧ ࡛ ࠶ ࡗ ࡓ ࠋ
21 㓄 ヨ㦂ᮇ㛫୰౪ヨ㤿ࡣヨ㦂㎰ሙ࡛⧅㣴ࡉࢀ࡚࠸ࡿ✀㞝㤿ࡼࡗ࡚ヨ㦂ࡣ ⊂❧ࡋ࡚ヨ㤿ࡢᛂᛂࡌ࡚✀㤿⟶⌮⪅ࡢุ᩿࡛✀㞝㤿ࡼࡿ⮬↛㓄࡛ ⾜ࢃࢀࡓࠋ ༸☜ㄆ ༸☜ㄆࡣ┤⭠᳨ᰝ࠾ࡼࡧ⤒┤⭠㉸㡢Ἴ᳨ᰝ࡚⾜ࡗࡓࠋ┤๓ࡢ᳨ᰝ࡛☜ ㄆࡉࢀࡓᖍ༸⬊ࡀ┤⭠᳨ᰝ࡛ゐ▱ࡉࢀࡎ㉸㡢Ἴ⏬ീ᳨ᰝ࡚ฟ⾑యࡀ☜ ㄆࡉࢀࡓࡇࡼࡗ࡚༸ࡋࡓࠋ㓄ᅇᩘึᅇ༸ࡽ 㛫௨ෆ ᪂ࡓ༸ࡀ☜ㄆࡉࢀࡓሙྜࢆ ༸ࡋ࡚ ༸⋡ࢆẚ㍑ࡋࡓࠋ ዷፎデ᩿ ༸☜ㄆ᪥ࢆ ᪥ࡋ࡚༸ᚋ ᪥ ᪥⤒┤⭠㉸㡢Ἴ᳨ᰝࡼࡿ⬇ ⬊☜ㄆࡼࡿዷፎデ᩿ࢆ⾜ࡗࡓࠋ ᅇࡶ⬇⬊ࡀ☜ㄆࡉࢀ⬇Ṛ⁛ࡀ☜ㄆࡉࢀ ࡞ࡗࡓࡇ࡛ዷፎ㝧ᛶデ᩿ࡋ୧⩌࠾ࡅࡿཷ⫾⋡ࢆẚ㍑ࡋࡓࠋ ⤫ィᏛⓗゎᯒ ⤖ᯝࡣᖹᆒ್sᶆ‽ㄗᕪ࡛♧ࡋࡓࠋᖍ༸⬊ᚄࡣ⥅⥆ࡋ࡚ィ ࡋ$129$ ࡢ ศᩓศᯒࡼࡾ༸⬊ᚄࡢኚࡘ࠸࡚ᢞ⩌ᑐ↷⩌ࡢ㛫࡛᭷ពᕪ᳨ᐃࢆ ⾜ࡗࡓࠋ⩌㛫࡛ࡢ༸⋡ዷፎ⋡ࡢ┦㐪ࡣࣇࢩ࣮ࣕࡢṇ☜⋡᳨ᐃ㓄ᅇᩘ
22 ࡣ࢙࢘ࣝࢳࡢ W ᳨ᐃ༸⋡ࡣ᳨࢝ᐃࢆ⾜ࡗࡓࠋࡍ࡚ࡢ⤫ィฎ⌮ ࡣࢥࣥࣆ࣮ࣗࢱ࣮ࡢࢯࣇࢺ࢚࢘ 6WDW9LHZ ࢆ⏝ࡋ 㸣ᮍ‶ࡢ༴㝤⋡࡛ ᭷ពᕪ࠶ࡾࡋࡓࠋ ⤖ᯝ ࣈࢭࣞࣜࣥᢞࡼࡿ༸⋡ 㛫௨ෆࡢ༸⋡ࡣࣈࢭࣞࣜࣥ ȣJ ᢞ⩌࡛ 㸣 ࣈࢭࣞࣜ ࣥ ȣJᢞ⩌ࡣ 㸣 ↓ฎ⨨⩌࡛ࡣ 㸣㸦㸧࡛࠶ࡗࡓ )LJ 㸯 ࠋࣈࢭࣞࣜࣥ ȣJᢞ⩌ࡢ 㛫௨ෆࡢ༸⋡ࡀ↓ฎ⨨⩌ẚ ࡚᭷ព㸦3㸺㸧㧗ࡗࡓࠋ ༸ࡲ࡛ࡢ༸⬊ᚄ࠾ࡼࡧᙧ≧ࡢኚ ༸๓ 㹼 ᪥ࡲ࡛ࡢᖹᆒ༸⬊ᚄࡢ᥎⛣ࢆ )LJ♧ࡋࡓࠋᑐ↷⩌࠾ࡼࡧ ᢞ⩌࠾ࡅࡿ༸๓ ᪥ࡢ༸⬊ᚄࡣࡑࢀࡒࢀ sPP Q ࠾ࡼࡧ s PP Q ࡛ ࠶ ࡾ ༸ ๓ ᪥ s PP Q ࠾ ࡼ ࡧ s PP Q ࡲ࡛ᡂ㛗ࡋ༸⮳ࡗࡓࠋᢞ⩌ᑐ↷⩌ࡢ༸⬊ᚄࡣ༸ྥࡅ⣙ 㛫࡛ 㹼PP ᡂ㛗ࡋࡓࡀ༸⬊Ⓨ⫱క࠺༸⬊ᚄࡣ୧⩌㛫᭷ព࡞ᕪࡣㄆ ࡵࡽࢀ࡞ࡗࡓࠋ 㛫㛫㝸࡛ほᐹࢆ⾜ࡗࡓᢞ⩌ࡢ ࠾࠸࡚ 㸦㸣㸧
23 ࡣ༸๓ 㹼 㛫࡛༸⬊ࡣ⌫ᙧࡽᴃᙧ㗹ᙧࡲࡓࡣὒ≧ࡢᙧែ ⓗኚࡀㄆࡵࡽࢀ༸ࡋࡓࡀ 㸦㸣㸧ࡣ⌫ᙧࡢࡲࡲ༸⮳ࡾ᫂ࡽ ࡞ᙧែⓗኚࢆ࿊ࡍࡿࡇ࡞ࡃ༸⮳ࡿࡶᏑᅾࡋࡓࠋ ༸ࡲ࡛ࡢᖍ༸⬊࠾ࡼࡧᏊᐑࡢᾋ⭘ീᡤぢࡢ᥎⛣ ᆺⓗ࡞୍࠾ࡅࡿᖍ༸⬊ࡢ☜ㄆࡽ༸ࡲ࡛ࡢᖍ༸⬊Ꮚᐑࡢᾋ ⭘ീࡢ㉸㡢Ἴ⏬ീࢆ )LJ♧ࡋࡓࠋࡇࡢ࡛ࡣ༸๓ ᪥㯤య PP ࡢᖍ༸⬊ࡀ☜ㄆࡉࢀࡇࡢᏊᐑయ࠾ࡼࡧᏊᐑゅ㒊ࡣᆒ୍࡞㧗㍤ᗘീࢆ࿊ ࡋᆺⓗ࡞㯤యᮇࡢᏊᐑീࡋ࡚☜ㄆࡉࢀࡓࠋ༸๓ ᪥࡛ࡣᖍ༸⬊ࡣ༸ ⬊ᚄ PP ᡂ㛗ࡋᏊᐑࡢᾋ⭘ീࡣ᭱ࡶ᫂░࡞ࡾ༸๓ ᪥ࡣᏊᐑࡢᾋ ⭘ീࡢῶᑡഴྥࡀㄆࡵࡽࢀࡓࠋࡇࡢᮇ㛫ᖍ༸⬊ࡣ㸯᪥⣙ 㹼PP ᡂ㛗ࡋ ༸๓ 㹼 㛫࡛ࡣᖍ༸⬊ࡣ PP ௨ୖᡂ㛗ࡋ⌫ᙧ࡛ࡣ࡞ࡃࢃࡎᴃ ᙧࢆ࿊ࡋᏊᐑࡢᾋ⭘ീࡣࡰᾘኻࡋ࡚࠸ࡓࠋ༸๓㸴㛫௨ෆ࡛ࡣ༸⬊ቨ ࡣࡉࡽ㧗㍤ᗘ࢚ࢥ࣮ᇦࡢ㔜ᵓ㐀ࡀ☜ㄆࡉࢀࡓᚋ༸⮳ࡾ༸ᚋࡣ ᖍ༸⬊ࡀᏑᅾࡋࡓ㒊ࡣฟ⾑యࡋ࡚ᆒ୍࡞㧗㍤ᗘീᇦࡋ࡚☜ㄆࡉࢀࡓࠋࡲ ࡓ༸ 㛫௨ෆࡢ༸⬊࡛༸⬊ᾮ୰ᑠࡉ࡞㧗࢚ࢥ࣮⢏Ꮚീࡀᩓぢࡉࢀ ༸⬊ቨࡢ㧗㍤ᗘീࡀ☜ㄆࡉࢀࡓࠋ
24 ༸ࡲ࡛ࡢ㛫 ౪ヨ㤿ࡢ 㛫㛫㝸࡛ࡢ༸⋡ࢆ )LJ♧ࡋࡓࠋ༸☜ㄆࡲ࡛ࡢ 㛫ࡣᢞ⩌ࡀ 㹼 㛫ᖹᆒ s Q 㛫ᑐ↷⩌ࡀ 㹼 㛫ᖹᆒ s Q 㛫࡛࠶ࡗࡓࠋᢞ⩌࡛ࡣ 㛫௨ෆࡢ༸⋡ࡀ 㸣 ࡛ 㠀ᢞ⩌ࡢ 㸣 ẚ㧗࠸ഴྥࡀㄆࡵࡽࢀࡓ 3Ҹ ࠋᢞ⩌࡛ ࡣ 㛫௨ෆ༸ࡀ☜ㄆࡉࢀࡓࡢࡀ 㸣 ࡲࡓ 㹼 㛫ࡀ 㸣 ⩌ศࢀࡓࠋᑐ↷⩌࡛ࡣ 㹼 㛫ᚋ༸ࡋࡓࡢࡣ 㢌㸦㸣㸧 ࡢࡳ࡛ 㢌㸦㸣㸧ࡣ 㛫௨ୖ⤒㐣ࡋࡓᚋ༸⮳ࡗࡓࠋ 㓄ᅇᩘ ༸⋡ཷ⫾⋡ ୍Ⓨ࠶ࡓࡾࡢ㓄ᅇᩘࡣᑐ↷⩌࡛ࡣ 㹼 ᅇᖹᆒ s Q ᅇᢞ ⩌࡛ࡣ 㹼 ᅇᖹᆒ s Q ᅇ࡛୧⩌᭷ព࡞ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ ᑐ↷⩌࡛ࡣ ᅇࡢ㓄ࡀ ࠶ࡗࡓࡀᢞ⩌࡛ࡣ ᅇ௨ୖ㓄ࡉࢀࡿࡣ࡞ ࡗࡓࠋᢞ⩌ࡢ 㛫௨ෆࡢ ༸⋡ࡣ 㸣 ࡛ᑐ↷⩌ࡢ 㸣 ẚ㧗࠸ഴྥࡀࡳࡽࢀࡓࡀ᭷ព࡞ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࠋཷ⫾⋡ࡣᢞ ⩌ᑐ↷⩌ࡶ 㸣 ࠾ࡼࡧ ࡛୧⩌ᕪࡣ࡞ࡃ⫾ዷፎࡶㄆࡵ ࡽࢀ࡞ࡗࡓࠋ㓄ᅇᩘ」ᩘ༸⋡ཷ⫾⋡ࢆ 7DEOH㸯♧ࡋࡓࠋ
25 ෆศἪືែ ᢞ⩌ࡣࣈࢭࣞࣜࣥᢞ᪥ᑐ↷⩌ࡣᢞ⩌ྠᵝPP ௨ୖࡢ༸⬊Ꮚ ᐑᾋ⭘ീࡢῶᑡࡀㄆࡵࡽࢀࡓ᪥ࢆ ᪥ࡋ༸๓ ᪥ࡽ ᪥ࡲ࡛ࡢ /+ )6+ ࣉࣟࢪ࢙ࢫࢸ࢚ࣟࣥࢫࢺࣛࢪ࣮࢜ࣝșࡢ᥎⛣ࢆ )LJ♧ࡋࡓࠋᢞ ⩌࠾ࡅࡿ್ࡣ㛤ጞ᪥ྠࡌ㛫ࡢ್ࡶࡋࡃࡣ๓ᚋࡢᖹᆒࢆ⏝࠸࡚㸯᪥㸯 ್ࡋ࡚ゎᯒࡋࡓࠋ /+ ࡢ᥎⛣ࡣᑐ↷⩌࡛ࡣ ᪥ s Q QJPO ࡽቑࡋ ᪥ࡣ s Q QJPO ୖ᪼ ᪥ s Q QJPO ῶᑡ㌿ࡌࡓࠋ୍ ᪉ᢞ⩌࡛ࡣ ᪥ࡲ࡛ᑐ↷⩌㢮ఝࡋ࡚᥎⛣ࡋࣈࢭࣞࣜࣥᢞ s Q QJPO ࢆ♧ࡋࡓࡀᢞᚋ ᪥ s Q QJPO ୍㐣ᛶୖ᪼ ࡋ ᪥ࡣ s Q QJPO ῶᑡࡋࡓࠋ )6+ ࡢ᥎⛣ࡣᑐ↷⩌࡛ࡣ༸๓ ᪥ࡽ ᪥ࡲ࡛ࡣ QJPO ࡢ㏆್࡛᥎⛣ ࡋ ᪥ࡽቑຍ㌿ࡌ ᪥ s Q QJPO ቑຍࡋࡓࠋ୍᪉ᢞ⩌ ࡣ ᪥ s Q QJPO ࡽ ᪥ s Q QJPO ୍㐣ᛶቑຍ ࡋ ᪥ s Q QJPO ῶᑡࡋᑐ↷⩌ᑐࡋ࡚ప್࡛࠶ࡗࡓࡀ᭷ព ࡞ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ 3ࡢ᥎⛣ࡣᢞ⩌ᑐ↷⩌ࡶ༸๓ ᪥ࡽ ᪥ࡅ࡚ QJPO ௨ୗࡢ ᇶᗏ್࡛᥎⛣ࡋ ᪥ࡽ ᪥୧⩌ቑຍ㌿ࡌᢞ⩌࡛ ᪥ s
26 Q QJPOᑐ↷⩌࡛ s Q QJPO ቑຍࡋࡓࠋ༸ࡀ 㛫௨ ෆ࡛࠶ࡗࡓᢞ⩌ࡢ 3ࡣ㧗࠸ഴྥ࡛࠶ࡗࡓࡀᑐ↷⩌ࡢ㛫᭷ព࡞ᕪࡣㄆࡵ ࡽࢀ࡞ࡗࡓࠋ (ࡢ᥎⛣ࡣᑐ↷⩌ࡣ༸๓ ᪥ࡽቑຍࡋ ᪥ s Q SJPO ࣆ࣮ࢡ㐩ࡋ ᪥ s Q SJPO ῶᑡࡋࡓࠋᢞ⩌࡛ࡣ ᪥ s Q ᪥ s Q SJPO ῶᑡࡋࡓࠋ୧⩌ࡶ༸☜ㄆ๓ ᚋపୗࡍࡿഴྥࡀㄆࡵࡽࢀࡓࠋ
27 ⪃ᐹ 㤿ࡢ༸ᮇண ࡢᣦᶆࡋ࡚ᖍ༸⬊ᚄᏊᐑࡢᾋ⭘ീᡤぢࡀ᭷⏝࡛࠶ ࡿࡉࢀ࡚࠸ࡿ> @ࠋ㤿ࡢ༸๓ࡢ༸⬊ᚄࡣ⣙ 㹼PP ࡉࢀᏘ ⠇ࡸ㤿ࡢ✀㢮ࡼࡗ࡚ኚືࡀ࠶ࡿ㹙㹛ࠋᮏ◊✲࠾࠸࡚ୡ⏺᭱⣭ࡢ㤿 ࡋ࡚ㄆ㆑ࡉࢀ࡚࠸ࡿ᪥ᮏ㍛⣔✀㸦㔜㍛㤿㸧ࡢ༸๓ࡢ༸⬊ᚄࡣ PP ௨ୖ࡛ PP ௨ୖ㐩ࡍࡿᖍ༸⬊ࡶㄆࡵࡽࢀሗ࿌ࡉࢀ࡚࠸ࡿ㤿ࡢᖹᆒⓗ࡞༸⬊ᚄ ࡼࡾ 㹼PP ᆺ࡛࠶ࡗࡓࠋࡲࡓ᪥ᮏࡢ㔜㍛㤿࠾ࡅࡿ༸๓ࡢ༸⬊ᚄ 㛵ࡍࡿሗ࿌>@ࡰ୍⮴ࡋ࡚࠸ࡓࠋ㤿ࡢᖍ༸⬊ࡢ┤ᚄࡣ༸ᮇࢆண ࡍ ࡿ᭱ࡶ᭷ຊ࡞ᣦᶆࡢ୍ࡘ࡛࠶ࡿࠋ㤿ࡢᖍ༸⬊ࡣᖹᆒ ᪥ࡅ࡚Ⓨ⫱ࡋ >@∵␗࡞ࡾ㛗㛫ࡅ࡚ᡂ⇍༸⬊ᡂ㛗ࡍࡿࠋࡋࡋ༸┤๓ࡢ 㤿ࡢ༸⬊ࡢ┤ᚄࡣ 㹼PP ಶయᕪࡀࡁ࠸ࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ>@ࠋヨ㦂 ᮇ㛫୰౪ヨ㤿ࡶྵࡵ࡚ほᐹࡍࡿࡇࡢ࡛ࡁࡓࡢ 㢌ࡢ༸ 㛫௨ෆ ࡢᖍ༸⬊ࡢ┤ᚄࡣ sPP ࡛㔜㍛㤿ࡢ༸๓ࡢᖍ༸⬊ࡢ┤ᚄࡣ⣙ 㹼PP ࡛㍍✀㤿ࡼࡾᆺ࡛࠶ࡗࡓ㸦7DEOH㸧ࠋࢧࣛࣈࣞࢵࢺ㞤㤿࠾࠸࡚ ᭱༸⬊ࡢ┤ᚄࡀ PP ௨ୗࡢࡶࡢࡢ༸⋡ࡣ 㸣PP ௨ୖࡢࡶࡢ࡛ࡣ 㸣Ⓨ⫱ࡶ༸⋡ࡢቑຍࡀㄆࡵࡽࢀࡿ>@ࠋ㔜㍛㤿㞤㤿࠾࠸࡚ ࡣ PP ௨ୗ࡛༸ࡍࡿࡇࡣᴟࡵ࡚⛥࡛࠶ࡾ㔜㍛㤿ࡢ༸ࡢᖍ༸⬊ࡢ ┤ᚄࡣ PP ௨ୖ࡛࠶ࡿ࠸࠼ࡿࠋ
28 㛗᪥ᛶᏘ⠇⦾Ṫື≀࡛࠶ࡿ㤿ࡣ⦾Ṫᮇ㛫୰ᮇࡼࡾⓎᣢ⥆㛫ᕪࡀ࠶ ࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿࡀ ᭶ ᭶ ᭶࡛ࡣ༸๓ 㛫௨ෆࡢᖍ༸⬊ࡢ ┤ᚄᕪࡣㄆࡵࡽࢀ࡞ࡗࡓ㸦7DEOH㸧ࠋ ༸๓ࡢ༸⬊ᙧ≧ࡣ 㸣ࡀ⌫ᙧࡽ㗹ὒࢼࢩ≧➼ᙧ≧ࡢኚࡀㄆࡵ ࡽࢀ 㸣ࡀ⌫ᙧࡢ≧ែ࡛༸⮳ࡗࡓ㍍✀㤿ࡢሗ࿌ࡀ࠶ࡿ>@ࠋ 㛫㛫㝸 ࡛ほᐹࢆ⾜ࡗࡓᢞ⩌࠾࠸࡚༸๓ 㛫⌫ᙧࢆ࿊ࡋ࡚࠸ࡓࡢࡣ 㸦㸣㸧࡛ 㸦㸣㸧ࡣ༸๓ 㹼 㛫ࡣ⌫ᙧࡽᴃᙧ㗹ᙧࡲ ࡓὒ≧ࡢ༸⬊ᙧࡢᙧែⓗኚࡀㄆࡵࡽࢀࡓࠋ༸ 㛫௨ෆࡢ༸⬊ቨ࡛ ࢚ࢥ࣮㍤ᗘࡢቑຍࡀࡳࡽࢀࡓࡣ༸⬊ෆᅽࡢኚࡼࡿᙳ㡪⪃࠼ࡽࢀ༸⬊ ᾮ୰ࡢᑠ࢚ࢥ࣮⢏Ꮚീࡢ☜ㄆࡣ༸๓ࡢฟ⾑㉳ᅉࡍࡿࡶࡢ⪃࠼ࡽࢀࡓࠋࡇ ࡢࡼ࠺࡞⌧㇟ࡣᚲࡎࡋࡶ༸⤖ࡧࡘࡃ⌧㇟࡛ࡣ࡞ࡃฟ⾑ࡀ⥅⥆ࡋ࡚ฟ⾑ᛶ ↓༸༸⬊㸦HAF Hemorrhagic Anovulatory Follicle㸧ࡶ▱ࡽࢀࡇࡢࡼ࠺࡞⌧㇟ ࡀ☜ㄆࡉࢀࡓሙྜࡣṇᖖ࡞༸ྰࡢ㚷ูデ᩿ࢆ⪃៖ࡍࡿᚲせࡀ࠶ࡿࠋ༸ ⬊ࡢᙧែⓗኚࡣ༸๓ ᪥ࡶㄆࡵࡽࢀࡿ㸦㸣㸧>@ࡇࡽ༸⬊ࡢᙧែ ⓗኚࡢࡳ࡛༸ᮇࢆ᥎ ࡍࡿࡇࡣ㐺ษ࡛ࡣ࡞࠸ሙྜࡶᏑᅾࡋ࠺ࡿࠋ㍍ ✀㤿࠾࠸࡚Ꮚᐑࡢᾋ⭘ീࡣ༸๓⣙ ᪥᭱ࡶ᫂░࡞ࡾ༸๓ 㹼 ᪥ῶ ᑡࡋ༸ᮇࡢ᭷ຊ࡞ᣦᶆࡉࢀ࡚࠸ࡿ>@ࠋࡋࡋ⦾Ṫࢩ࣮ࢬ ࣥ⛣⾜ᮇࡢ༸ࢆకࢃ࡞࠸Ⓨ࠾࠸࡚ࡶ 㸣Ꮚᐑࡢᾋ⭘ീࡀㄆࡵࡽࢀ
29 >@ࡲࡓᏊᐑෆ⭷⅖࠾࠸࡚㧗ᗘ࡞ᾋ⭘ീࡀㄆࡵࡽࢀࡿ>@ࡇࡽᏊ ᐑࡢᾋ⭘ീᡤぢࡢࡳ࡛༸ࡢᮇࢆุᐃࡍࡿࡇࡶ㐺ษ࡛ࡣ࡞࠸ࠋࡇࡢࡼ࠺࡞ ࡇࡽᖍ༸⬊ࡢ┤ᚄ࠾ࡼࡧᙧ≧Ꮚᐑࡢᾋ⭘ീࡢ⛬ᗘྜࢃࡏ࡚⏕Ṫჾ ࡢ┤⭠᳨ᰝᡤぢ Ꮚᐑࡢ◳ᗘ እᏊᐑཱྀ㸦ᘱ⦆㸧እ㝜㒊ࡢእㇺᡤぢ㸦ᘱ⦆㸧 ࢆ⥲ྜⓗุ᩿ࡋ㓄㐺ᮇࢆุ᩿ࡍࡿࡇࡀᮃࡲࡋ࠸࠸࠼ࡿࠋࣈࢭࣞࣜࣥ ᢞᮇࢆPP ௨ୖࡢᖍ༸⬊ࢆ᭷ࡋᏊᐑࡢᾋ⭘ീࡢῶᑡタᐃࡋࡓ ࡇࢁ 㛫௨ෆࡢ༸⋡ࡣ 㸣࡛࠶ࡾ 㛫௨ෆࡀ 㸣 㹼 㛫ࡀ 㸣 ⩌ศࢀࡓࠋ 㛫௨ෆ༸ࡀ☜ㄆࡉࢀࡓ⩌ࡣ ᢞࡍ࡛༸㏆ఝࡋࡓෆᅉᛶࡢ࣍ࣝࣔࣥືែ࡛࠶ࡗࡓࡇࡀ᥎ ࡉࢀࡿࠋ ༸ࡀ 㹼 㛫㞟୰ࡍࡿഴྥࡀㄆࡵࡽࢀࡓࡇࡣࣈࢭࣞࣜࣥᢞࡼ ࡿ /+)6+ ࡢ୍㐣ᛶࡢୖ᪼ࡀ༸⬊ࡢᡂ⇍ࢆ᪩ࡵ༸ࢆಁ㐍ࡋࡓ᥎ ࡉࢀࡿࠋ PP ௨ୖࡢ༸⬊ࢆ᭷ࡍࡿ㍍✀㤿ࡢK&* ᢞ࠾࠸࡚ࡶ༸ࡀ 㛫๓ᚋ 㞟୰ࡍࡿഴྥࡀ࠶ࡿࡢሗ࿌㹙㹛ྠᵝ࡞ഴྥࡀㄆࡵࡽࢀࡓࠋ㤿ࡣ」ᩘ ༸⋡ࡀ㧗ࡃ≉ࢧࣛࣈࣞࢵࢻ✀࡛ࡣ 㸣 ༸ࡀㄆࡵࡽࢀ᪩ᮇዷፎデ ᩿㸦༸ᚋ 㹼 ᪥㸧࠾࠸࡚ 㸣⫾ዷፎࡀㄆࡵࡽࢀ࡚࠸ࡿ㹙㹛ࠋᮏ ヨ㦂࡛ࡣ ༸⋡ࡀᢞ⩌࡛㧗࠸㸦㸣㸧ഴྥ࠶ࡗࡓࡀ୧⩌ࡢཷ⫾⋡ࡣ ࡑࢀࡒࢀ 㸣 ࡛ᕪࡣ࡞ࡃ༴ࡉࢀࡓ⫾ዷፎࡣㄆࡵࡽࢀ࡞ ࡗࡓࠋ
30 㢖ᅇ㓄ࡀᖖែࡋ࡚࠸ࡿ㔜㍛㤿⏕⏘࠾࠸࡚㓄ᅇᩘࡢపῶࡣ㓄ㄏᑟ ᛶᏊᐑෆ⭷⅖ࡢࣜࢫࢡࢆపୗࡍࡿ࠺࠼࡛ࡢㄢ㢟࡛࠶ࡿࠋヨ㦂ᮇ㛫୰୧⩌ࡶ ✀㤿⟶⌮⪅ࡢุ᩿࡛✀㞝㤿ࡼࡿ⮬↛㓄ࡀ⾜ࢃࢀ㓄ᅇᩘ᭷ព࡞ᕪࡣㄆ ࡵࡽࢀ࡞ࡗࡓࠋࡋࡋᑐ↷⩌࡛ࡣ୍Ⓨ ᅇ㓄ࡀ ࠶ࡗࡓࡀᢞ⩌ ࡛ࡣ ᅇ㓄ࡣ࡞ࡃ࡚ ᅇ௨ෆ࡛࠶ࡗࡓࠋ㢖ᅇ㓄ࢆ㑊ࡅࡿࡇࡣ㓄ㄏᑟ ᛶᏊᐑෆ⭷⅖ࡢࣜࢫࢡࢆపୗࡋ✀㞝㤿ࡢ㈇ᢸ㍍ῶࡼࡿά⏝ࡢಁ㐍᭷⏝ ࡛࠶ࡿ⪃࠼ࡽࢀࡿࠋ ࣈࢭࣞࣜࣥ༢ᅇᢞࡼࡿෆศἪືែࡢኚࡣ ᑐ↷⩌ẚ㍑ࡋ࡚ /+)6+ ࡳࡽࢀࡓࠋᑐ↷⩌ࡢ /+ ࡣ༸ ᪥๓ࡼࡾቑࡋ༸ 㹼 ᪥ᚋࣆ࣮ࢡ 㐩ࡋሗ࿌ࡉࢀ࡚࠸ࡿ㍍✀㤿ࡢ /+ ศἪࣃࢱ࣮ࣥ㏆ఝࡋ࡚࠸ࡓ>@ࠋ୍᪉ ᢞ⩌࡛ࡣᢞ 㹼 㛫୍㐣ᛶࡢୖ᪼ࢆ♧ࡋࡓࡢࡕప್࡛᥎⛣ࡋࡓࠋࣈࢭ ࣞࣜࣥᢞࡼࡾ /+ ศἪࡀಁ㐍ࡉࢀᛶ⭢่⃭࣍ࣝࣔࣥศἪ⣽⬊ࡀ⬺ឤస≧ ែ࠶ࡿ /+ ศἪ㈇ࡢࣇ࣮ࢻࣂࢵࢡࡀാ࠸࡚࠸ࡿࡇࡀ᥎ᐹࡉࢀࡓࠋ 㤿ࡢ༸๓ᚋ࠾ࡅࡿ )6+ ࡣᑐ↷⩌ྠᵝ༸ᚋୖ᪼ࢆ㛤ጞࡍࡿෆศ Ἢືែࡀ▱ࡽࢀ࡚࠸ࡿ㹙㹛ࠋࡋࡋᢞ⩌࡛ࡣᢞ 㹼 ᪥ᚋ୍㐣ᛶࡢୖ ᪼ࢆ♧ࡋ༸ᚋࡣప್࡛᥎⛣ࡋࡓࠋࣈࢭࣞࣜࣥᢞࡼࡿ )6+ ศἪ่⃭ࡼ ࡿ /+ ࡢ᥎⛣ྠᵝࡢస⏝ࡀ᥎ᐹࡉࢀࡓࠋ ࣉࣟࢪ࢙ࢫࢸࣟࣥࡣ༸ࡲ࡛ᇶᗏ್࡛᥎⛣ࡋ༸ᚋ 㹼 㛫ୖ᪼ࡋ
31 㹼 ᪥᭱㐩ࡍࡿࡉࢀ> @୧⩌ࡶྠᵝࡢ᥎⛣ࢆ♧ࡋࡓࠋᢞ ⩌࡛ࡣ༸ࡀ࡚ᢞᚋ 㛫௨ෆ☜ㄆࡉࢀᢞᚋ ᪥ࡢࣉࣟࢪ࢙ࢫࢸࣟ ್ࣥࡣ㧗ࡗࡓࡇࡽࣈࢭࣞࣜࣥᢞᚋࡢ㯤యᙧᡂᑐࡍࡿෆศἪⓗᙳ㡪 ࡣ࡞࠸ࡶࡢ᥎ᐹࡉࢀࡿࠋ ࢚ࢫࢺࣛࢪ࣮࢜ࣝșࡢ᥎⛣ࡣῶᑡഴྥ㌿ࡌ࡚༸⮳ࡾሗ࿌ࡉࢀ ࡚࠸ࡿ㍍✀㤿ࡢ࢚ࢫࢺࣛࢪ࣮࢜ࣝșศἪࣃࢱ࣮ࣥ㏆ఝࡋ࡚࠸ࡓ㹙㹛ࠋ ༸๓ࡢ K&* ᢞࡼࡗ࡚ ࢚ࢫࢺࣛࢪ࣮࢜ࣝșࡢῶᑡ༸⬊Ⓨ⫱ࡢṆ ࡢ㛵㐃ࡀᣦࡉࢀ࡚࠸ࡿ>@ࠋ࢚ࢫࢺࣛࢪ࣮࢜ࣝșࡣᆺ༸⬊ࡢ㢛⢏ᒙ ࡽศἪࡉࢀ༸⬊ࡢⓎ⫱ᡂ⇍ᐦ᥋㛵ࡋ࡚࠸ࡿࠋᏊᐑࡢᾋ⭘ീᡤぢࡀ ῶᑡࡍࡿᮇࡣ ࢚ࢫࢺࣛࢪ࣮࢜ࣝșࡀῶᑡ㌿ࡌ༸ྥࡅࡓ༸⬊ᡂ⇍ ࡢᣦᶆ࡞ࡾ࠺ࡿࠋᮏ◊✲࠾࠸࡚ࡶ࢚ࢫࢺࣛࢪ࣮࢜ࣝșࡀῶᑡഴྥ࡛ ༸ࡀㄆࡵࡽࢀࡓࡇࡽ࢚ࢫࢺࣛࢪ࣮࢜ࣝșࡢືែࡀᏊᐑࡢᾋ⭘ീ㛵 ࡋ࡚࠸ࡿࡇࡀ᥎ᐹࡉࢀࡓࠋ ᮏ◊✲࡛ࡣࣈࢭࣞࣜࣥᢞ⩌ࡢ 㛫௨ෆࡢ༸⋡ࡀ 㸣࡛࠶ࡾ㔜㍛㤿 㞤㤿ࡀ┤ᚄPP ௨ୖࡢᖍ༸⬊ࢆ᭷ࡋᏊᐑࡢᾋ⭘ീࡀῶᑡഴྥࢆ♧ࡋࡓ ࢆᐈほⓗ࡞㓄㐺ᮇࡋࡇࡢᮇ࠾ࡅࡿࣈࢭࣞࣜࣥ ȣJ ༢ᅇᢞࡀ༸ ྠᮇ᭷⏝࡛࠶ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡉࡽ༸ㄏ㉳ࡼࡾ㓄ᅇ ᩘࢆῶࡽࡍࡇࡣ㓄ㄏᑟᛶᏊᐑෆ⭷⅖ࡢࣜࢫࢡࢆపῶࡋ㔜㍛㤿ࡢຠ⋡ⓗ
32
⾨⏕ⓗ࡞⦾Ṫ⟶⌮ᢏ⾡ࡢ୍ࡘ࡞ࡾ࠺ࡿࡇࡀ᥎ᐹࡉࢀࡓࠋࡉࡽ㔜㍛㤿ࡢ ⏕⏘⌧ሙࡢ⋇་ᖌࡢ✚ᴟⓗ࡞㛵ࡼࡿேᕤᤵ⢭ᢏ⾡ࡢᬑཬ⤖ࡧࡘࡇ ࡀ♧၀ࡉࢀࡓࠋ
33 ᑠᣓ 㔜㍛㤿㞤㤿ࡢⓎᮇࡢᖍ༸⬊Ꮚᐑࡢᙧែⓗኚࢆ㉸㡢Ἴ⏬ീ᳨ᰝࡼࡾ ⤒ⓗほᐹࡋ ࣈࢭࣞࣜࣥࡢ༢ᅇᢞࡀ༸ෆศἪືែཬࡰࡍᙳ㡪ࢆ᳨ ウࡋࡓࠋ㔜㍛㤿ࡢ༸ 㛫௨ෆࡢᖍ༸⬊ࡢ┤ᚄࡣ sPP ࡛༸ ๓ࡢᖍ༸⬊ࡢ┤ᚄࡣ㍍✀㤿ࡼࡾᆺ࡛࠶ࡗࡓࠋࡲࡓᏊᐑࡢᾋ⭘ീࡣ༸๓ ῶᑡࡶࡋࡃࡣᾘኻࡀ☜ㄆࡉࢀࡓࠋ㔜㍛㤿㞤㤿 㢌ࢆࣈࢭࣞࣜࣥᢞ⩌ Q ᑐ↷⩌ Q ศ㢮ࡋヨ㤿ࡼࡿⓎᚩೃࢆ♧ࡋ PP ௨ୖࡢᖍ༸⬊ࡀ Ꮡᅾࡋ๓ᅇ᳨ᰝᡤぢẚ㍑ࡋ࡚Ꮚᐑࡢᾋ⭘ീࡢῶᑡࡀㄆ㆑ࡉࢀࡓࢆ㓄㐺 ᮇࡋ࡚ࣈࢭࣞࣜࣥ ȣJ ࢆ㢁㒊➽⫗ෆᢞࡋࡓࠋ⤒ⓗ⤒┤⭠㉸㡢Ἴ⏬ ീ᳨ᰝࡼࡿ༸⬊Ꮚᐑࡢほᐹ⾑୰ /+)6+ࣉࣟࢪ࢙ࢫࢸ࢚ࣟࣥࢫࢺࣛ ࢪ࣮࢜ࣝșࢆ ᐃࡋࡓࠋࡑࡢ⤖ᯝ 㛫௨ෆࡢ༸⋡ࡣᢞ⩌ 㸣 ࡛ᑐ↷⩌ 㸣 ẚ㧗ࡃ 3 ༸☜ㄆࡲ࡛ࡢᖹᆒ㛫ࡣ ᢞ⩌ s 6(0 㛫࡛ᑐ↷⩌ࡢ s 6(0 㛫ࡼࡾ▷㛫࡛༸⮳ࡗ ࡓࠋ㓄ᅇᩘ༸⋡ཷ⫾⋡ࡣ୧⩌ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࠋࣈࢭࣞࣜ ࣥᢞᚋ 㹼 ᪥ /+ )6+ ࡣ୍㐣ᛶୖ᪼ࡋᑐ↷⩌࠾ࡅࡿ /+ ࡣ༸ 㧗ࡃ )6+ ࡣ༸⬊ࡢᡂ㛗క࠸୍㐣ᛶࡢୖ᪼ࡀㄆࡵࡽࢀࡓࠋPP ௨ୖࡢᖍ༸ ⬊ࢆ᭷ࡋᏊᐑࡢᾋ⭘ീࡀῶᑡഴྥࢆ♧ࡋࡓࢆ㔜㍛㤿㞤㤿ࡢ㐺ษ࡞㓄㐺ᮇ ࡋࣈࢭࣞࣜࣥ ȣJ ༢ᅇᢞࡣ༸ㄏ㉳ຠᯝࢆ᭷ࡋ༸ࡢྠᮇ᭷⏝
34
35
㝃㸧ᅗ⾲
Fig.1-1. Outline of experiment.
36
Fig.1-2.Measure of dominant follicle diameter.
37
Fig.1-3. Comparison of the ovulation rate of the control mares and
those administered 40 and 20 μg buserelin.
A dose of 40 or 20 μg buserelin was intramuscularly administered when mares presented signs of estrus to a teaser stallion and dominant follicles reached more than 45 mm in diameter. The ovulation rate within 48 hr in the control group was evaluated under the same conditions. The ovulation rate within 48hr after administration of 40μg buserelin was significantly higher than that of the control group, comparison between the 40μg buserelin group and control group. *P< 0.01 for
38
Fig.1-4. Changes in mean follicle diameter from 5 days before to 1 day
before ovulation.
The mean follicle diameters (major axis + minor axis/2) from 5 days before (−5) to 1 day before (−1) ovulation are shown. Day 0 is the day of ovulation.
39
Fig.1-5. Temporal change in dominant follicle and uterine image
until ovulation. ↑㸸echogenic follicular wall.
40
Fig.1-6. Interval between treatment and ovulation (hr).
The time of buserelin administration was designated 0 hr for the treated group, and the time at which the follicle diameter was more than 45 mm and uterine edema was decreased was designated as 0 hr for the control group.
41
Fig.1-7. Plasma concentrations of LH, FSH, progesterone, and
estradiol-17β.
Day 0 for the treated group was the day of buserelin administration, and for the control group, it was when follicles of more than 45 mm in diameter and a decrease in uterine edema were confirmed. For the treated group, values measured at the same time as the first day or averages of values taken around the same time were used as the date each day for analysis.
LH(ng/ml)㻌 0 1 2 3 4 -3 -2 -1 0 1 2 3 4 FSH(ng/ml)㻌 d㻌 0 2 4 6 -3 -2 -1 0 1 2 3 4 d㻌 0 1 2 3 -3 -2 -1 0 1 2 3 4 Progesterone (ng/ml) d㻌 Estradiol-17β(pg/ml 0 2 4 6 8 10 -3 -2 -1 0 1 2 3 4 d㻌 㼀㼞㼑㼍㼠㼑㼐㻌㼓㼞㼛㼡㼜㻌 㻯㼛㼚㼠㼞㼛㼘㻌㼓㼞㼛㼡㼜㻌 meansSEM
42
43
44
➨
2 ❶
㔜㍛㤿㞤㤿࠾ࡅࡿ⬇⬊Ⓨ⫱ኚࡢ≉ᚩ
45 ᗎㄽ ⋇་⒪࠾ࡅࡿ㉸㡢Ἴ᳨ᰝࡢศ㔝ࡣࡇࡢ ᖺ㛫࡛Ⓨᒎࡋࡑࡢ᭱ึࡢ⏝ ࡣ㤿ࡢ᪩ᮇዷፎ㚷ᐃ࡛࠶ࡗࡓࡉࢀࡿࠋࡑࡢ᭱ึࡢ⏝௨᮶ᢏ⾡ࡣ㣕㌍ⓗ ྥୖࡋᵝࠎ࡞⏝㏵࡛ᛂ⏝ࡉࢀ᪥⮳ࡗ࡚࠸ࡿࠋ㤿ࡢ⮫ᗋᦠࢃࡿከࡃࡢ⋇་ ᖌࡀ㉸㡢Ἴデ᩿⨨ࢆ⏝ࡋ࠸ࡲࡸ㉸㡢Ἴ᳨ᰝࡣ࢚ࢵࢡࢫ⥺᳨ᰝࡶ㤿 ࡢ⏬ീデ᩿ࡢຊ࡞ࡗ࡚࠸ࡿࠋ㤿ࡣ㛗᪥ᛶࡢᏘ⠇⦾Ṫື≀࡛㓄ᮇࡀ㝈 ᐃࡉࢀ ༸⋡⫾ዷፎ⋡ࡀ㧗ࡃࡲࡓ᪩ᮇ⬇Ṛ⁛ࡢⓎ⏕⋡ࡀ㧗࠸ࡇ ࡀ▱ࡽࢀ࡚࠸ࡿ>@ࠋࡇࡢࡼ࠺࡞⫼ᬒࡽ㤿ࡢዷፎデ᩿࡛᭱ึᛂ ⏝ࡉࢀࡓ㉸㡢Ἴ᳨ᰝࡣࡃ㤿ࡢ᪩ᮇዷፎデ᩿༢⫾⫾ࡢ㚷ูデ᩿ጾ ຊࢆⓎࡋࡑࡢᢏ⾡ࡣⓎᒎᬑཬࡋ⥆ࡅ࡚࠸ࡿࠋࡲࡓ㤿ࡣ㛗᪥ᛶࡢᏘ⠇⦾ Ṫື≀࡛㓄ᮇ㛫ࡀ㝈ᐃࡉࢀཷ⫾ࡢᡂྰࡼࡾ⏕⏘ᛶࡣࡁࡃᕥྑࡉࢀࡿࡇ ࡽ᪩ᮇࡢዷፎデ᩿⬇⬊ࡢⓎ⫱ࢫࢸ࣮ࢪᇶ࡙࠸ࡓⓗ☜࡞ዷፎデ᩿ࡀせ ồࡉࢀࡿࠋࡋࡋ㤿࡛Ⓨ㐩ࡋࡓ㉸㡢Ἴデ᩿ᢏ⾡ࡣ㍍✀㤿࡛◊✲ࡀ㐍ࢇ࡛࠸ࡿ ࡀయ㔜ࡀ㍍✀㤿ࡢ⣙㸰ಸ㏆࠸ୡ⏺᭱⣭ࡢ㤿ࡋ࡚ㄆ㆑ࡉࢀ࡚࠸ࡿ᪥ᮏᤂ⣔ ✀㔜㍛㤿ࡢዷፎデ᩿⬇⬊Ⓨ⫱⤒㐣ࡢ≉ᚩ㛵ࡍࡿሗ࿌ࡣ࡞࠸ࠋ᪩ᮇࡢዷፎ デ᩿⬇⬊Ⓨ⫱ࢫࢸ࣮ࢪࡼࡿ≉ᚩࢆᢕᥱࡋࡓୖ࡛ࡢⓗ☜࡞ዷፎデ᩿ࡣ༢⫾ ⫾ࡢ㚷ูデ᩿ࡸᏊᐑෆ⭷ᄞ⬊㸦ࢩࢫࢺ㸧ࡢ㚷ูデ᩿ࡶጾຊࢆⓎࡋ㔜 ㍛㤿ࡢ⏕⏘ຠ⋡ྥୖࢆᅗࡿࡓࡵ⋇་ᖌࡗ࡚ᚲ㡲ࡢᢏ⾡࡛࠶ࡿࠋ
46 ➨ ❶࡛ࡣ㉸㡢Ἴ⏬ീ᳨ᰝࡼࡿ㔜㍛㤿ࡢ⬇⬊Ⓨ⫱ኚࡢ≉ᚩࢆ᫂ࡽ ࡋዷፎデ᩿ࡢࡓࡵࡢᶆ‽ീゐデ࡛ࡣண ᅔ㞴࡞ᮇࡽࡢ⫾㱋ண ࡢྍ ⬟ᛶࢆ᳨ウࡋ᪩ᮇ⬇Ṛ⁛ࡸ␗ᖖ࡞⬇Ⓨ⫱ࢆ᪩ᮇⓎぢࡍࡿ㚷ูデ᩿ࡢ᰿ᣐࢆ᫂ ☜ࡍࡿࡇࢆ┠ⓗࡋࡓࠋ
47 ヨ㦂ᴫせ ౪ヨ㤿 ᾏ㐨ᖏᗈᕷෆ㣫㣴ࡉࢀ࡚࠸ࡿṇᖖ࡞Ⓨ࿘ᮇࢆ᭷ࡍࡿᮍ⤒⏘ࡽ⏘ḟᩘ ࡢ␗࡞ࡿ⤒⏘㤿 ṓ㹼 ṓࡢ㔜㍛㤿㞤㤿㏙ 㢌ࢆヨ㦂౪ࡋࡓࠋ ヨ㦂᪉ἲ ヨ㤿ࡼࡿእ㒊Ⓨᚩೃࡀほᐹࡉࢀ࡚ࡽ ᪥ ᅇ⥅⥆ࡋ࡚┤⭠᳨ᰝ࠾ ࡼࡧ㉸㡢Ἴ⏬ീ᳨ᰝࡼࡾ༸ࡲ࡛ᖍ༸⬊ࡢ☜ㄆࢆ࠾ࡇ࡞ࡗࡓࠋ⤒┤⭠ࡽ ࡢ༸ᕢゐデࡼࡗ࡚๓᪥☜ㄆࡉࢀࡓᖍ༸⬊ࡀゐ▱ࡉࢀࡎ㉸㡢Ἴ᳨ᰝ ࡚ฟ⾑యࡀ☜ㄆࡉࢀࡓࡇࢆࡶࡗ࡚༸デ᩿ࡋࡓࠋ༸☜ㄆ᪥ࢆ ᪥ࡋ࡚ ᪥ࡼࡾ⤒┤⭠ࡽᏊᐑࡢ㉸㡢Ἴ⏬ീ᳨ᰝࡼࡾᏊᐑゅ࠾ࡼࡧᏊᐑయ㒊ࡢ⏬ ീデ᩿ࡼࡿዷፎデ᩿㸦⬇⬊ࡢ☜ㄆ㸧ࢆ⾜ࡗࡓࠋ ✀ࡅࡣ࡚⮬↛㓄࡛✀ 㤿⟶⌮⪅ࡢุ᩿࡛ Ⓨᮇࡘࡁ 㹼 ᅇ⾜ࢃࢀࡓࠋ ㉸㡢Ἴ⏬ീ᳨ᰝ ᭱ึ⬇⬊ࡀ☜ㄆࡉࢀࡓࡢࡣ㸷᪥࡛ಶయࡼࡗ࡚ ᪥ࡲ࡛⬇⬊ࡢ☜ㄆ ࡽᙧែⓗⓎ⫱⤒㐣ࢆ㉸㡢Ἴデ᩿⨨>66'ࣟ࢝ᮾி@ 0+] ࣜࢽᆺ ┤⭠᳨ᰝ⏝᥈ゐᏊ>867ࣟ࢝ᮾி@ࢆ᥋⥆ࡋ࡚ほᐹࡋࡓࠋ⬇⬊ࡢ㟼Ṇ ⏬ീࡢ௵ពࡢ㛗ᚄ▷ᚄࢆ ᐃࡋࡑࡢᖹᆒࢆ⬇⬊ᚄࡋ࡚⬇⬊ࡢⓎ⫱⤒㐣ࢆ ほᐹࡋࡓ㸦)LJ㸧ࠋ
48 ⤖ᯝ ⬇⬊ࡀ᭱ࡶ᪩ࡃほᐹࡉࢀࡓࡢࡣ ᪥㸦PP㸧࠶ࡿ࠸ࡣ ᪥㸦PP㸧࡛࠶ࡾ ᙧ㸦⌫≧㸧ࡢ↓࢚ࢥ࣮ᛶࡢ㸦ᾮయ࡛‶ࡓࡉࢀࡓ㸧㡿ᇦࡋ࡚Ꮚᐑゅࡢᶓ᩿ 㠃ࡢ୰ᚰ☜ㄆࡉࢀࡓࠋ⬇⬊ࡢከࡃࡣ ᪥㸦sPP㸧௨㝆⌫ᙧࡢ ↓࢚ࢥ࣮ᛶࡢᙧ㸦⌫≧㸧ࡢᵓ㐀≀ࡋ࡚ほᐹࡉࢀࡓࠋ㹼 ᪥㸦sPP㸧 ࡣᙧ㸦⌫≧㸧ࡢ↓࢚ࢥ࣮ᛶࡢ࢝ࣉࢭࣝࡋ࡚᫂ࡽ⬇⬊ࢆ☜ㄆࡍࡿࡇ ࡀ࡛ࡁࡓࠋࡇࡢᮇ㛫ࡣᙧ㸦⌫≧㸧࡛᥎⛣ࡋ⬇⬊ࡢከࡃࡢ⫼ഃ⭡ഃࡢቃ ⏺࡛ࡣ㉸㡢Ἴࡢ≀⌮ⓗᑕീ࡛࠶ࡿṇᑕ㸦specular reflections㸧ࡀ㧗㍤ᗘ࢚ ࢥ࣮ീࡋ࡚ほᐹࡉࢀࡓ㸦)LJ㸧ࠋࡲࡓࡇࡢᮇ㛫ࡣ㉸㡢Ἴ᳨ᰝࢆ⾜ࡗ࡚ ࠸ࡿ㛫ࡢ⛣ືᛶࡀ㧗ࡃ ≉ 㹼 ᪥࡛ࡣᏊᐑෆࢆᐜ᫆⛣ືࡍࡿࡇࡀほ ᐹࡉࢀࡓࠋ㹼 ᪥ࡢ⬇⬊ࡣከࡃࡢᙧ≧ࡀ୍ᐃ࡛࠶ࡿࡀᙧ㸦⌫≧㸧࡛ࡣ࡞ ࡃࢃࡎ༸ᙧࢆ࿊ࡋ ᪥㸦sPP㸧௨㝆ࡣḟ➨୕ゅᙧࢆ࿊ࡋ つ๎࡞ᙧ≧࡛᥎⛣ࡋࡓࠋ㹼 ᪥ࡢ⬇⬊ࡣ୍ᐃࡢྜ࡛⬇⬊ᚄࡢቑ㸦 s㹼sPP㸧ࡀ☜ㄆࡉࢀࡓ㸦)LJ㸧ࠋࡲࡓ ᪥௨㝆ࡣᏊᐑෆ࡛ ࡢ⛣ືᛶࡣほᐹࡉࢀ࡞ࡗࡓࠋ㹼 ᪥⬇⬊ࡢ⭡ഃ㸱ศࡢ㸯ࡢ㡿ᇦ⬇Ꮚ 㸦㹼PP㸧ࢆ☜ㄆࡍࡿࡇࡀ࡛ࡁࡓࡀࡑࢀ௨እࡢ㡿ᇦ࡛⬇Ꮚࡣ☜ㄆࡉࢀ࡞ ࡗࡓ㸦)LJ㸧ࠋ⣙ 㹼 ᪥ࡢ⬇⬊ࡣ୕ゅᙧࡸつ๎࡞ᙧ≧࡛᥎⛣ࡋࡓ ࡀ⬇⬊ᚄࡣ PP ๓ᚋ࡛ࡁ࡞ኚࡣほᐹࡉࢀ࡞ࡗࡓࠋ ᪥๓ᚋࡽ ᪥㡭ࡲ࡛ࡢ⬇⬊ࡣつ๎࡛ᖹᆠ࡞ᙧ≧࡛Ⓨ⫱ࡍࡿᵝᏊࡀほᐹࡉࢀࡑࢀ௨ᚋ
49 ࡣࡧ୍ᐃࡢྜ࡛⬇⬊ᚄࡢቑࡀほᐹࡉࢀ ᪥௨㝆࡛ࡣ⬇⬊ࡣつ๎࡞ ᙧ≧࡛ PP ௨ୖⓎ⫱ࡋࡓ㸦)LJ㸧ࠋ ᪥๓ᚋࡢ⬇Ꮚࡣ⬇⬊ࡢ⭡ഃ㒊 ⨨ࡍࡿࡀḟ➨ 㹼 ᪥࡛ࡣ⬇⬊ࡢ୰ኸ⛣ືࡍࡿࡇࡀほᐹࡉࢀࡓࠋ ࡲࡓ ᪥௨㝆࡛⬇Ꮚࡢ୍㒊࡛ᚰᢿࡀ☜ㄆ࡛ࡁ ᪥௨㝆࡛ࡣ᫂ࡽ⬇Ꮚ ᚰᢿࢆ☜ㄆࡍࡿࡇࡀ࡛ࡁࡓࠋ
50 ⪃ᐹ ༸ᕢࡸᏊᐑࡢ≧ែࢆᢕᥱࡍࡿ࠺࠼࡛㉸㡢Ἴ᳨ᰝࡢ᭷⏝ᛶࡣᴟࡵ࡚㧗ࡃከ ࡃࡢሙྜࡣ 㹼0+] ࡢࣜࢽᆺࣉ࣮ࣟࣈࢆᛂ⏝ࡍࡿࡇࡀ᥎ዡࡉࢀ࡚࠸ࡿ㹙㹛ࠋ ᮏ◊✲࠾࠸࡚ࡶ 0+] ࡢࣜࢽᆺࣉ࣮ࣟࣈࢆ⏝࠸࡚Ⰻዲ࡞⏬ീࢆᥥࡍࡿࡇ ࡀྍ⬟࡛࠶ࡗࡓࠋ⤒┤⭠ࡽࡢゐデ㉸㡢Ἴ⏬ീ᳨ᰝ࡛ฟ⾑యࢆ☜ㄆࡍࡿࡇ ࡛༸デ᩿ࡋࡓࡀ༸ᚋ 㛫௨ෆㄆࡵࡽࢀࡿฟ⾑యࡣゐデࡢࡳ ࡛ࡣ༸๓ࡢ༸⬊ゐデୖࡢឤゐࡀ㠀ᖖ㢮ఝࡋ࡚࠸ࡓ㹙㹛ࠋࡋࡋ㉸㡢 Ἴ⏬ീ᳨ᰝ࡛ࡣ୍┠░↛࡛࠶ࡾゐデࡢࡳ࡛ࡢ༸デ᩿ࢆ⾜࠺ሙྜࡣ⣽ᚰࡢὀ ព㓄៖ࡀᚲせ࡛࠶ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ㓄ࡋࡓಶయ࡛ࡣ༸ᚋ㸴᪥ ๓ᚋ⬇┙⬊ࡀ༸⟶ࡽᏊᐑෆ⭍⛣⾜ࡍࡿࡀ⬇┙⬊ࢆ༸ᚋ㸷᪥๓㉸ 㡢Ἴ⏬ീ᳨ᰝ࡛ᥥฟࡍࡿࡇࡣᅔ㞴ࡉࢀ࡚࠸ࡿ㹙㹛ࠋᮏ◊✲࠾࠸ ࡚ࡶ㸵᪥ࡽ㉸㡢Ἴ⏬ീ᳨ᰝࢆ⾜ࡗࡓࡀ⬇⬊ࡣ㸵᪥ ᪥☜ㄆࡉࢀࡿࡇ ࡀ࡞ࡃ ᪥㸦PP㸧௨㝆ᙧ㸦⌫≧㸧ࡢ↓࢚ࢥ࣮ᛶ㡿ᇦࡋ࡚Ꮚᐑゅࡢᶓ ᩿㠃ࡢ୰ᚰ☜ㄆࡉࢀࡓࠋ⬇⬊ࡢከࡃࡣ ᪥㸦sPP㸧௨㝆ᙧ㸦⌫ ≧㸧ࡢ↓࢚ࢥ࣮ᛶ㡿ᇦࡋ࡚ほᐹࡉࢀࡓࠋ ᪥௨๓࡛ࡣ⬇⬊ࡀほᐹࡉࢀ࡞࠸ ሙྜࡶ࠶ࡾ༸᪥ࡀ☜ㄆࡉࢀ࡚࠸࡞࠸ሙྜࡣ᭱⤊✀ࡅࡽ ᪥௨㝆 ዷፎデ᩿ࢆ⾜࠺ࡇ⪃៖ࡍࡿᚲせࡀ࠶ࡿࠋ㹼 ᪥㸦sPP㸧ࡣ᫂ࡽ ⬇⬊ࢆ☜ㄆࡍࡿࡇࡀ࡛ࡁ⬇⬊ࡢከࡃࡢ⫼ഃ⭡ഃࡢቃ⏺࡛㉸㡢Ἴࡢ ≀⌮ⓗᑕീ࡛࠶ࡿṇᑕ㸦specular reflections㸧ࡀ㧗㍤ᗘ࢚ࢥ࣮ീࡋ࡚ほᐹ
51 㸦)LJ㸧ࡉࢀࡓࡇࡽࡇࡢᮇ㛫࡛ࡢᏊᐑෆ⭷ࡢᄞ⬊㸦ࢩࢫࢺ㸧ࡢ㢮 㚷ูデ᩿࠾࠸࡚ ṇᑕ㸦specular reflections㸧ࡢ᭷↓ࡢ☜ㄆࡣ᭷⏝࡛࠶ࡿࠋ ࡍ࡞ࢃࡕࠊᏊᐑෆ⭷ࡢᄞ⬊㸦ࢩࢫࢺ㸧ࡢᙧ≧ࡣᩚᙧ࡛ṇᑕ㸦specular reflections㸧 ࡀほᐹࡉࢀࡿࡇࡣ⛥࡛࠶ࡿࠋࡲࡓࡇࡢᮇ㛫ࡣ⛣ືᛶࡀ㧗ࡃ ≉ 㹼 ᪥࡛ࡣᏊᐑෆࢆᐜ᫆⛣ືࡍࡿࡀ㹼 ᪥௨㝆࡛ࡣ⛣ືᛶࡀ☜ㄆࡉࢀ࡞ࡗ ࡓࠋ⬇⬊ࡢᡂ㛗Ꮚᐑࡢ⥭ᙇࡣᏊᐑෆ⭍ࢆ⛣ືࡍࡿ⬇⬊ࡀ㏻ᖖࡢᅛ╔㒊 ࡍࡿᏊᐑゅᇶ㒊ᅛ╔ࡍࡿ⫾㱋 ᪥ࡲ࡛⥆ࡃࡉࢀ㹙㹛⬇⬊ᚄࡣࢃࡎ ᆺ࡛᥎⛣ࡋࡓ㔜㍛㤿࠾࠸࡚ࡶࡰྠᵝࡢ⌧㇟ࡀほᐹࡉࢀࡓࠋᅛ╔๓ࡢ ⬇⬊ࡣᏊᐑࡽࡢࣉࣟࢫࢱࢢࣛࣥࢪࣥࡢᨺฟࢆ㜼ᐖࡍࡿࡓࡵᏊᐑෆ⭷⾲ 㠃య᥋ゐࡋ࡞ࡀࡽ⛣ືࡋࡇࡢ⛣ືᛶࡣ㤿ࡢዷፎㄆ㆑ࡢᮇࡉࢀࡿ༸ ࡽ ᪥᭱┒ᮇࢆ㏄࠼ࡿࡉࢀ࡚࠸ࡿ㹙㹛ࠋࡇࢀࡽࡢࡇࡽ㔜 ㍛㤿ࡢዷፎデ᩿ࡢึᅇࡢ㐺ṇᮇࡣ⛣ືᛶࢆ᭷ࡋ᫂ࡽ⬇⬊ࡀ☜ㄆ࡛ࡁࡿ ༸ᚋ 㹼 ᪥ࡀ⌮ⓗ࠸࠼ࡿࠋࡇࡢᮇ࡛࠶ࢀࡤ⫾ዷፎࡀ☜ㄆࡉࢀࡓ ሙྜ࡛ࡶᐜ᫆ῶ⫾ࡋࡓ࠸⬇⬊ࢆᏊᐑゅࡢඛ➃⛣ືࡋ࡚ࢡࣛࢵࢩࣥࢢࡍࡿ ࡇࡀྍ⬟࡛࠶ࡿࠋ㹼 ᪥⬇⬊ࡢ⭡ഃ㸱ศࡢ㸯ࡢ㡿ᇦ⬇Ꮚ㸦㹼PP㸧 ࡀ☜ㄆࡉࢀࡓࡀࡑࢀ௨እࡢ㡿ᇦ࡛⬇Ꮚࡣ☜ㄆࡉࢀ࡞ࡗࡓ㸦)LJ㸧ࠋ ᪥௨㝆ࡢ⬇⬊࠾࠸࡚⬇Ꮚࡀ☜ㄆࡉࢀ࡞࠸ሙྜࡣࡍ࡛⬇Ṛ⁛⬇⬊࡛ࡣ ࡞ࡃᏊᐑෆ⭷ᄞ⬊㸦ࢩࢫࢺ㸧ࢆ⪃៖ࡍࡿࡁ࡛࠶ࡿࠋ㹼 ᪥ࡢ⬇⬊ࡣ୕ゅ
52 ᙧࡸつ๎࡞ᙧ≧࡛᥎⛣ࡋࡓࡀ⬇⬊ᚄࡣ PP ๓ᚋ࡛ࡁ࡞ኚࡣほᐹࡉࢀ ࡞ࡗࡓࠋ࣏ࢽ࣮㍍✀㤿࠾࠸࡚⬇⬊ࡢᡂ㛗᭤⥺ࡣ 㹼 ᪥ࡢᮇ࠾࠸ ࡚ࡣ┤⥺ⓗ࡛࠶ࡾ 㹼 ᪥࡛ࡣ⬇⬊ࡣ୍ᐃࡢࡁࡉ࡛᥎⛣ࡋ ᪥௨㝆 ࡧᡂ㛗᭤⥺ࡀ┤⥺ⓗ࡞ࡿ㹑Ꮠ≧࣮࢝ࣈࢆ♧ࡍࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ>@ࠋ ࡰ୍ᐃࡢࢧࢬ࡛⥔ᣢࡉࢀࡿ 㹼 ᪥ࡢ⬇⬊ᚄࡣ 㹼PP ࡛᥎⛣ࡋ࣏ࢽ ࣮ࡼࡾ㍍✀㤿ࡢ᪉ࡀࡁ࠸ഴྥࡀ࠶ࡗࡓࡀࡢ᪥㱋࡛ࡣࡁ࡞ᕪࡣ࡞࠸ࡉ ࢀ࡚࠸ࡿ>@ࠋ㔜㍛㤿࠾࠸࡚ࡶྠᵝ㹑Ꮠ≧࣮࢝ࣈࢆ♧ࡍᡂ㛗᭤⥺ࡀほᐹ ࡉࢀࡓࡀ㹼 ᪥ࡢ⬇⬊ᚄࡣ㹼PP ࡛ሗ࿌ࡉࢀ࡚࠸ࡿ࣏ࢽ࣮ࡸ㍍✀㤿ࡼ ࡾࡁ࠸ഴྥࡀほᐹࡉࢀࡓ㸦)LJ㸧ࠋࡇࡢࡼ࠺࡞ᕪࡣ㤿ࡢ✀㢮ࡼࡿᏊᐑ ᙧ≧ࡢࡁࡉ㉳ᅉࡍࡿࡇࡀ᥎ ࡉࢀࡿࠋ⬇⬊ࡢⓎ⫱᭤⥺ࡀ୍ᐃ࡞ࡿᮇ㛫 ࡣ༸㯤ᄞࡢ⦰ᑠᑐࡋ࡚ᒀ⭷ᄞࡀቑࡍࡿࡇࡼࡗ࡚⬇⬊ࡢయീኚ ࡀ࡞࠸ᮇ࡛࠶ࡾ⬇⬊ᙧ≧ࡢኚࡣⓎ⫱క࠺ᏊᐑࡢᅽຊᏊᐑෆ⭷ᙧ≧ ࡼࡿࡶࡢ⪃࠼ࡽࢀࡿࠋ ᪥௨㝆ࡣᒀ⭷ᄞࡢቑࡼࡗ࡚ࡧ┤⥺ⓗ࡞Ⓨ ⫱᭤⥺ࢆ♧ࡍࡇࡀ⪃࠼ࡽࢀࡓࠋ ᪥๓ᚋࡢ⬇Ꮚࡣ⬇⬊ࡢᗏ㒊⨨ࡍࡿࡀ ḟ➨ 㹼 ᪥࡛ࡣ⬇⬊ࡢ୰ኸ⛣ືࡍࡿࡇࡀほᐹࡉࢀࡇࡢࡇࡣ༸ 㯤ᄞࡢ⦰ᑠక࠺⌧㇟࡛࠶ࡿ⪃࠼ࡽࢀࡓࠋࡲࡓ ᪥௨㝆࡛⬇Ꮚࡢ୍㒊࡛ᚰ ᢿࡀ☜ㄆ࡛ࡁ ᪥௨㝆࡛ࡣ᫂ࡽ⬇Ꮚࡢᚰᢿࢆ☜ㄆࡍࡿࡇࡀ࡛ࡁࡓࠋࡇ ࡢࡇࡽࡇࡢᮇ⬇Ꮚࡢᚰᢿࡀ☜ㄆ࡛ࡁ࡞࠸ሙྜࡣ⬇Ṛ⁛ࢆ⪃៖ࡍࡿ
53 ࡁ࡛࠶ࡿࠋ 㤿ࡢ⌮ⓗ࡞ዷፎデ᩿ࡢᮇࡋ࡚⬇⬊ࡢⓎ⫱⤒㐣ᛂࡌ࡚」ᩘᅇ⾜࠺ࡇ ࡀ⌮ⓗ࡛࠶ࡿࠋࡍ࡞ࢃࡕዷፎデ᩿ࡣึᅇࡀ⫾ዷፎࡢሙྜࡢῶ⫾ฎ⨨ࡢ ྍ⬟ᛶࡽ⬇⬊ࡢᏊᐑෆᅛ╔ࡀ㉳ࡇࡿ๓ 㹼 ᪥ ᅇ┠ࡀ 㹼 ᪥ ᅇ┠ ࡣ 㹼 ᪥ࡑࡋ࡚⛅ࡢ ᅇᐇࡍࡿࡇࡀᮃࡲࡋ࠸ࡉࢀ࡚࠸ࡿ>@ࠋࡋ ࡋ⤒῭ⓗ⌮⏤➼ࡽ㔜㍛㤿ࡢ⦾Ṫ⌧ሙ࡛ࡣ㢖ᅇዷፎデ᩿ࡀᅔ㞴࡛࠶ࡿሙ㠃 ࡀከ࠸ࠋዷፎデ᩿ࡣ」ᩘᅇ⾜࠺ࡇࡀ⌮ⓗ࡛ࡣ࠶ࡿࡀ㸯ᅇࡢࡳᐇࡍࡿ㝿 ࡢᮇࡋ࡚ࡣ⬇Ṛ⁛⋡ࡀపୗࡋ>@᫂ࡽᚰᢿࡢほᐹࡀ࡛ࡁࡿ ᪥๓ ᚋᐇࡍࡿࡇࡀᮃࡲࡋ࠸>@ࠋ)LJ༸☜ㄆᚋ 㹼 ᪥ࡲ࡛ᐃᮇ ⓗほᐹࡋࡓྠ୍㔜㍛㤿ࡢ⬇⬊ࡢ㉸㡢Ἴ⏬ീࢆᶆ‽ീࡋ࡚♧ࡋࡓࠋ 㔜㍛㤿ࡢᐃᮇⓗ࡞ዷፎデ᩿ࢆ⾜࠺ᙜࡓࡾ⬇⬊ࡢⓎ⫱⤒㐣క࠺≉ᚩ 㸦)LJ㸧ࢆᢕᥱࡋࡓୖ࡛ዷፎデ᩿ࢆࡍࡿࡇࡀ㔜せ࡛࠶ࡿࠋ㔜㍛㤿ࡢ⌮ ⓗ࡞ዷፎデ᩿ࡢᮇᅇᩘࡋ࡚ึᅇࡣ⫾ዷፎࡢሙྜῶ⫾ฎ⨨ࡀྍ⬟࡞ ᪥๓ᚋ ᅇ┠ࡣ⬇Ṛ⁛⋡ࡀపୗࡋ⬇Ꮚᚰᢿࡀ☜ㄆ࡛ࡁࡿ ᪥๓ᚋࡢ ᅇ ⾜࠺ࡇࡀ⌮ⓗ࡛࠶ࡿࠋࡲࡓࡇࡢࡇࡼࡗ࡚ṇᖖ࡞⬇⬊ࡢⓎ⫱Ꮚᐑෆ ⭷ᄞ⬊㸦ࢩࢫࢺ㸧ࡢ㢮㚷ู⫾ዷፎࡸ᪩ᮇ⬇Ṛ⁛ࡢデ᩿ࢆⓗ☜⾜࠺ࡇ ࡀ࡛ࡁ㝈ࡽࢀࡓ㓄ᮇ㛫ຠ⋡ⓗⓗ☜࡞㓄ࡀྍ⬟࡞ࡾ㔜㍛㤿ࡢ⦾ Ṫຠ⋡ࡢྥୖ⤖ࡧࡘࡃࡇࡀ᥎ᐹࡉࢀࡓࠋ
54 ᑠᣓ 㔜㍛㤿ࡢዷፎデ᩿ࡢ⢭ᗘࢆྥୖࡍࡿࡓࡵ⬇⬊ࡢⓎ⫱ኚࡢ≉ᚩࢆ᫂ࡽ ࡋ⬇⬊Ⓨ⫱ࡢᶆ‽ീࢆసᡂࡍࡿࡇࢆ┠ⓗࡋ࡚◊✲ࢆ⾜ࡗࡓࠋ㔜㍛㤿㞤 㤿ࡢ 㢌ࡘ࠸࡚༸☜ㄆ᪥ࢆ ᪥ࡋ 㹼 ᪥ࡲ࡛⬇⬊ࡢ☜ㄆࡽ⬇ ⬊ࡢᙧែⓗⓎ⫱ኚࢆ㉸㡢Ἴデ᩿⨨࡚ほᐹࡋࡓࠋ⬇⬊ࡢ௵ពࡢ㛗ᚄ▷ᚄ ࢆ ᐃࡋࡑࡢᖹᆒࢆ⬇⬊ᚄࡋ࡚ほᐹࡋࡓࠋࡑࡢ⤖ᯝ⬇⬊ࡣ ᪥࡛ PP ࡢᙧ㸦⌫≧㸧ࡢ↓࢚ࢥ࣮㡿ᇦࡢ⬇⬊ࡋ࡚☜ㄆࡉࢀ 㹼 ᪥ࡣᙧ㸦⌫≧㸧 ࡽ༸ᙧ 㸦sPP㸧㹼 ᪥㸦sPP㸧ࡣ⬇⬊ᚄࡁ࡞ኚ ࡣ࡞ࡃつ๎࡞ᙧែ࡛᥎⛣ࡋࡓࠋ 㹼 ᪥㸦PP㸧ࡣつ๎࡞ᙧែ࡛ᗘ⬇ ⬊ᚄࡢቑຍࡀほᐹࡉࢀࡓࠋ㹼 ᪥࡛⬇Ꮚࡢ☜ㄆ ᪥๓ᚋ࡛⬇Ꮚࡢᚰᢿࡀ ☜ㄆ࡛ࡁࡓࠋ㍍✀㤿ࡢ⬇⬊ᚄࡣ 㹼 ᪥ࡲ࡛ࡣ PP ๓ᚋ࡛᥎⛣ࡍࡿࡢሗ࿌ ẚ㔜㍛㤿ࡢ⬇⬊ࡣᆺ㸦⣙ PP㸧࡛᥎⛣ࡋࡓࠋ୍᪉⬇⬊ᚄࡢⓎ⫱ క࠺ኚࡸ㹑Ꮠ≧࣮࢝ࣈࡢᡂ㛗᭤⥺⬇Ꮚࡢᙧែⓗኚࡣሗ࿌ࡉࢀ࡚࠸ࡿ ࡢ㤿ྠᵝ࡛࠶ࡗࡓࠋ㔜㍛㤿ࡢ⌮ⓗ࡞ዷፎ㚷ᐃࡢᮇᅇᩘࡋ࡚ึᅇࡣ ⫾ዷፎࡢሙྜῶ㏥ฎ⨨ࡀྍ⬟࡞ ᪥๓ᚋ ᅇ┠ࡣ⬇Ṛ⁛⋡ࡀపୗࡋ⬇Ꮚ ᚰᢿࡀ☜ㄆ࡛ࡁࡿ ᪥๓ᚋࡢ ᅇ⾜࠺ࡇࡀ⌮ⓗ࡛࠶ࡿ⪃࠼ࡽࢀࡓࠋ
55 㝃㸧ᅗ⾲
Fig. 2-1. Measure of embryonic vesicle diameter.
56
Fig.2-2. Growth of embryonic vesicle days 9 to 16.
It was first confirmed as a 5–6-mm spherical echo-free region on days 9
and 10 and remained spherical on days 12–16; specular reflectionss
(arrows) were confirmed.
57
Fig.2-3. Expansion profile from cross sections of embryonic vesicle.
The rate of expansion appeared to increase gradually over day 9 to 10,
and then expansion increased linearly to day 18, day 18 to 28 were
S-shaped, with distinct plateau during approximately days 18 to 28.
Values are presented as meansSEM.
58
Fig.2-4. Growth of embryonic vesicle days 9 to 16.
After days 19 embryonic vesicles grew in spherical to irregular shapes,
around days 22 to 25 embryo proper was confirmed, then the diameter of
embryonic vesicles remains unchanged around 35 mm over days 18–28.
59
Fig.2-5. Days 18 to 28 with distinct plateau, embryonic vesicle diameter
were 30 to 40 mm in heavy draft horses, that were bigger than other
horses (Ginther,1996). Schematic illustrations of the embryonic vesicle
on 19, 25 and 30 days after maiting are depicted on the top.
60
Fig.2-6. Standard image of growth of embryonic vesicles in the same
heavy draft mare.
Morphological changes of embryonic vesicles from day 10, at which
embryonic vesicles could be confirmed, to day 30 after confirmation of
ovulation in the same heavy draft mare.
61
62 ୡ⏺᭱⣭ࡢ㤿ࡋ࡚ㄆ㆑ࡉࢀ࡚࠸ࡿ㔜㍛㤿㸦᪥ᮏᤂ⣔✀㸧ࡢ⏝ࡣࡤࢇ ࠼࠸➇㉮㤿⫗⏝㤿ᙺ㤿ࡋ࡚ࡢ୕㠃ᛶࡀ࠶ࡾࡑࡢ⏕⏘ࡣᡃࡀᅜ≉᭷ࡢ 㤿⏕⏘⏘ᴗ࡛࠶ࡿࠋࡋࡋ㔜㍛㤿ࡢ⏘㥖⏕⏘⋡ࡣ⣙ 㸣ᙅ㍍✀㤿ẚ ⣙ 㸣పࡃ᥎⛣ࡋ࡚࠸ࡿࠋࡑࡢせᅉࡋ࡚㔜㍛㤿ࡢ≉␗࡞⦾Ṫ⏕⌮ࡀ᫂ࡽ ࡉࢀ࡚࠾ࡽࡎ⋇་Ꮫⓗ࡞ᑐᛂ⟇ࡀ༑ศㅮࡌࡽࢀ࡚࠸࡞࠸Ⅼࡀᣲࡆࡽࢀ ࡿࠋࡑࡇ࡛㔜㍛㤿ࡢ⦾Ṫ≉ᛶࢆ᫂ࡽࡋ ᖺ ⏘ࢆ┠ᣦࡋࡓ⏕⏘ຠ⋡ࢆ ⥔ᣢࡍࡿࡓࡵࡢᑐᛂ⟇ࢆ᳨ウࡋࡓࠋ ➨ ❶࡛ࡣ㔜㍛㤿ࡢ㓄㐺ᮇࡢᣦᶆࢆ᫂ࡽࡍࡿࡓࡵ㉸㡢Ἴ⏬ീ᳨ᰝ ࡼࡿⓎᮇࡢ༸ᕢ㸦༸⬊㸧࠾ࡼࡧᏊᐑࡢᙧែኚࢆ⤒ⓗほᐹࡋ༸๓ ᚋࡢᖍ༸⬊Ꮚᐑࡢᙧែⓗ≉ᚩࢆほᐹࡋࡓࠋࡲࡓ㔜㍛㤿㞤㤿ࡢ༸ࡢྠᮇ ࢆ┠ⓗࡋࡓ *Q5+ 㢮ఝయࣈࢭࣞࣜࣥ༢ᅇᢞࡘ࠸࡚ࡑࡢ༸ㄏ㉳ຠᯝ ෆศἪືែࡢᙳ㡪ࢆㄪᰝࡋࡓࠋ 㐃⥆ࡍࡿ ⦾Ṫࢩ࣮ࢬࣥࡢ 㹼 ᭶ᾏ㐨ᖏᗈᕷ㣫㣴ࡉࢀ࡚࠸ࡿṇᖖ࡞ Ⓨ࿘ᮇࢆ᭷ࡍࡿ㔜㍛㤿㞤㤿ࡢ 㢌ᑐࡋ࡚༸ㄏ㉳ࡢࡓࡵࡢࣈࢭࣞࣜ ࣥ⮳㐺ᢞ㔞ࡢ᳨ウヨ㦂ࢆ⾜ࡗࡓࠋヨ㤿ࡼࡿⓎᚩೃࢆ♧ࡋ㹼 ᪥㛫 ࡢ⤒┤⭠㉸㡢Ἴ᳨ᰝ࡚┤ᚄ PP ௨ୖࡢᖍ༸⬊ࡀㄆࡵࡽࢀࡓࣈࢭࣞ ࣜࣥ ȣJ㸦Q 㸧࠶ࡿ࠸ࡣȣJ㸦Q 㸧ࢆ➽⫗ෆᢞࡋ↓ฎ⨨࡛⤒㐣ほ ᐹࢆ⾜ࡗࡓᑐ↷⩌㸦Q 㸧ྜࢃࡏ࡚ 㛫௨ෆࡢ༸⋡ࢆㄪᰝࡋຠᯝⓗ
63 ࡞ࣈࢭࣞࣜࣥ༢ᅇᢞ㔞ࢆ᳨ウࡋࡓࠋࡑࡢ⤖ᯝࣈࢭࣞࣜࣥ ȣJ ᢞ⩌ࡢ 㛫௨ෆࡢ༸⋡ࡣ 㸣 ࡛࠶ࡾᑐ↷⩌ࡢ 㸣㸦㸧ẚࡋ࡚᭷ ព㸦3㸺㸧㧗ࡗࡓࠋࡇࡢ⤖ᯝࡼࡾࣈࢭࣞࣜࣥᢞ㔞ࢆ ȣJ タᐃ ࡋ௨㝆ࡢヨ㦂ࢆ⾜ࡗࡓࠋ༸๓ᚋࡢෆศἪືែࢆ᫂ࡽࡍࡿࡓࡵṇᖖ࡞ Ⓨ࿘ᮇࢆ᭷ࡍࡿ㔜㍛㤿㞤㤿ࡢ 㢌ᑐࡋ࡚ࣈࢭࣞࣜࣥᢞヨ㦂ࢆ⾜ࡗ ࡓࠋヨ㤿ࡼࡿⓎᚩೃࢆ☜ㄆࡋ┤ᚄ PP ௨ୖࡢᖍ༸⬊ࡀ☜ㄆࡉࢀ Ꮚᐑᾋ⭘ീࡢῶᑡࡀほᐹࡉࢀࡓࣈࢭࣞࣜࣥȣJࢆ➽⫗ෆᢞࡍࡿᢞ ⩌㸦Q 㸧ྠᵝࡢほᐹⅬࡽ↓ฎ⨨࡛༸ࡲ࡛⤒㐣ࢆほᐹࡍࡿᑐ↷⩌ Q ༊ศࡋࡓࠋᢞ⩌ࡣ༸ࡲ࡛ 㛫㛫㝸༸☜ㄆᚋࡣ 㛫ࡲ࡛ 㛫㛫㝸࡛ᑐ↷⩌ࡣ༸☜ㄆᚋ 㛫ࡲ࡛ 㛫㛫㝸࡛⤒┤⭠㉸㡢Ἴ᳨ ᰝࡼࡾ༸⬊㸦༸ᕢ㸧࠾ࡼࡧᏊᐑࡢᙧែኚࢆほᐹࡋࡓࠋ༸⬊ࡢ㟼Ṇ⏬ീ ࡽ㸦㛗ᚄ㸩▷ᚄ㸧 ࢆ༸⬊ᚄࡋ࡚ィ ࡋࡓࠋࡲࡓ୧⩌ࡶ㉸㡢Ἴ᳨ᰝ ᥇⾑ࢆ⾜࠸࣍ࣝࣔࣥ ᐃ౪ࡋ༸๓ᚋࡢෆศἪືែࢆㄪᰝࡋࡓࠋ 㔜㍛㤿ࡢ༸๓᪥ࡢほᐹ࠾ࡅࡿ༸⬊┤ᚄࡣᑐ↷⩌ᢞ⩌ࡑࢀࡒࢀ sPP㸦Q 㸧s PP㸦Q 㸧࡛࠶ࡾ༸⬊┤ᚄࡣ༸ྥࡅ࡚㸯᪥ ࠶ࡓࡾ 㹼PP ๓ᚋᡂ㛗ࡋ༸⬊Ⓨ⫱క࠺༸⬊┤ᚄ୧⩌ᕪࡣ࡞ࡃሗ࿌ ࡉࢀ࡚࠸ࡿ㤿ࡢ༸๓ࡢᖹᆒⓗ࡞༸⬊┤ᚄࡼࡾᆺ࡛࠶ࡗࡓࠋ ࣈࢭࣞࣜࣥ ȣJ ᢞࡼࡾ༸ࡋࡓ ࠾࠸࡚༸ 㛫๓⌫ᙧࢆ
64 ࿊ࡋ࡚࠸ࡓࡢࡣ 㸦㸣㸧࡛ 㸦㸣㸧ࡣ༸๓ 㹼 㛫ࡣ⌫ᙧ ࡽ㗹ᙧࡲࡓὒ≧ࡢᙧែⓗኚࡀㄆࡵࡽࢀࡓࠋ༸⬊ࡢᙧែኚࡣ༸ ᪥๓ࡶㄆࡵࡽࢀࡿࡇࡽ༸⬊ࡢᙧែኚࡢࡳ࡛༸ᮇࢆ᥎ ࡍࡿࡇ ࡣ㐺ษ࡛ࡣ࡞࠸⪃࠼ࡽࢀࡓࠋ Ꮚᐑࡢᾋ⭘ീࡣ༸๓ 㹼 ᪥᭱ࡶ᫂░࡞ࡾ༸ 㹼 ᪥๓ῶᑡഴྥ ࢆ♧ࡋࡓࠋࣈࢭࣞࣜࣥᢞᚋ 㛫௨ෆࡢ༸⋡ࡣᢞ⩌࡛ 㸣 ࡛࠶ࡾᑐ↷⩌ 㸣 ẚ㧗࠸ 3 ഴྥࡀㄆࡵࡽࢀࡓࠋᢞ ࡽ༸ࡲ࡛ࡢ㛫ࡣ 㛫௨ෆࡀ 㸣 㹼 㛫ࡀ 㸣 ࡛ ⩌ศࢀ༸ࡀࣈࢭࣞࣜࣥᢞᚋ 㹼 㛫㞟୰ࡍࡿഴྥࡀㄆࡵࡽ ࢀࡓࠋ ᑐ↷⩌࡛ࡣ /+ ࡣ༸㧗ࡃ)6+ ࡣ༸ᚋୖ᪼ࡀㄆࡵࡽࢀࡓࡢᑐࡋ ᢞ⩌࡛ࡣࣈࢭࣞࣜࣥᢞ 㹼 㛫ᚋ/+)6+ ࡣ୍㐣ᛶୖ᪼ࡋࡓࡀ ࡑࡢᚋୖ᪼ࡣࡳࡽࢀ࡞ࡗࡓࠋᢞ⩌࡛ࡣ /+)6+ ࡢ୍㐣ᛶୖ᪼ࡀࡳࡽࢀࡓࡇ ࡽࣈࢭࣞࣜࣥᢞࡼࡾᛶ⭢่⃭࣍ࣝࣔࣥศἪ⣽⬊ࡀ⬺ឤస≧ែ࠶ࡿ /+)6+ ศἪ㈇ࡢࣇ࣮ࢻࣂࢵࢡࡀാ࠸࡚࠸ࡿࡇࡀ᥎ ࡉࢀࡓࠋ/+ )6+ ࡢ୍㐣ᛶࡢୖ᪼ࡀ༸⬊ࡢᡂ⇍ࢆ᪩ࡵ༸ࢆಁ㐍ࡋࡓ᥎ᐹࡉࢀࡿࠋ 㓄ᅇᩘ ༸⋡ཷ⫾⋡ࡣ୧⩌㛫ᕪࡀㄆࡵࡽࢀ࡞ࡗࡓࠋࣈࢭࣞࣜࣥ ᢞ⩌ࡢ 㛫௨ෆࡢ༸⋡ࡀ 㸣࡛࠶ࡾ㔜㍛㤿㞤㤿ࡀ┤ᚄ PP ௨ୖࡢ
65 ᖍ༸⬊ࢆ᭷ࡋᏊᐑࡢᾋ⭘ീࡀῶᑡഴྥࢆ࿊ࡋࡓࢆ㓄㐺ᮇࡋࣈࢭࣞ ࣜࣥ ȣJ ༢ᅇᢞࡢ༸ྠᮇࡢ᭷⏝ᛶࡀ᫂ࡽ࡞ࡗࡓࠋࡉࡽ༸ㄏ ㉳ࡼࡾ㓄ᅇᩘࢆῶࡽࡍࡇࡣ㓄ㄏᑟᛶᏊᐑෆ⭷⅖ࡢࣜࢫࢡࢆపῶࡋ 㔜㍛㤿ࡢຠ⋡ⓗ⾨⏕ⓗ࡞⦾Ṫ⟶⌮ᢏ⾡࡞ࡾ࠺ࡿࡇࡀ᥎ᐹࡉࢀࡓࠋ 㤿ࡣ᪩ᮇ⬇Ṛ⁛ࡢⓎ⏕⋡ࡀ㧗ࡃ᪩ᮇࡢዷፎデ᩿⬇⬊ࡢⓎ⫱ࢫࢸ࣮ࢪᛂ ࡌࡓⓗ☜࡞ዷፎデ᩿ࡀせồࡉࢀࡿࡀ㔜㍛㤿ࡢዷፎࢫࢸ࣮ࢪ࠾ࡅࡿ⬇⬊Ⓨ⫱ ࡢᙧែⓗ≉ᚩࡢሗ࿌ࡣ࡞࠸ࠋࡑࡇ࡛➨ ❶࡛ࡣ㔜㍛㤿࠾ࡅࡿⓗ☜࡞᪩ᮇ ዷፎデ᩿ࡢᣦᶆࢆ☜❧ࡍࡿࡓࡵ⬇⬊Ⓨ⫱ࡢᙧែⓗ≉ᚩࢆㄪᰝࡋࡓࠋ ᾏ㐨ᖏᗈᕷ㣫㣴ࡉࢀ࡚࠸ࡿ㔜㍛㤿㞤㤿ࡢ 㢌ࢆヨ㦂౪ࡋࡓࠋヨ 㤿ࡼࡿⓎᚩೃࢆ♧ࡋ⮬↛㓄ᚋᖍ༸⬊ࡢ༸☜ㄆ᪥ࢆ ᪥ࡋ࡚ 㹼 ᪥ࡲ࡛㉸㡢Ἴデ᩿⨨ࢆ⏝࠸࡚⬇⬊ࡢ☜ㄆⓎ⫱⤒㐣క࠺⬇⬊ࡢᙧ ែኚࢆほᐹࡋࡓࠋ⬇⬊ࡢ㛗ᚄ▷ᚄࢆ ᐃࡋࡑࡢᖹᆒࢆ⬇⬊ᚄࡋ࡚グ㘓 ࡋࡓࠋ 㔜㍛㤿ࡢ⬇⬊ࡣ༸ᚋ 㹼 ᪥࡛ 㹼PP ࡢᙧ㸦⌫≧㸧ࡢ↓࢚ࢥ࣮㡿ᇦ ࡋ࡚Ꮚᐑゅࡢᶓ᩿㠃ࡢ୰ᚰ☜ㄆࡉࢀࡓࠋࡋࡋ ᪥௨๓࡛ࡣ⬇⬊ࡀ ほᐹࡉࢀ࡞࠸ሙྜࡶከࡃ༸᪥ࡀ≉ᐃࡉࢀ࡚࠸࡞࠸ሙྜࡣ᭱⤊✀ࡅࡽ ᪥௨㝆ࡢዷፎデ᩿ࡀᮃࡲࡋ࠸⪃࠼ࡽࢀࡓࠋ⬇⬊ࡢከࡃࡣ ᪥㸦s PP㸧㹼 ᪥㸦sPP㸧ࡣᙧ㸦⌫≧㸧ࡢ↓࢚ࢥ࣮㡿ᇦࡢ࢝ࣉࢭࣝ
66 ࡋ࡚᫂ࡽほᐹࡉࢀࡓࠋࡇࡢᮇ⫼ഃ⭡ഃࡢቃ⏺࡛ࡣṇᑕ㸦specular reflectionss㸧ࡀ㧗㍤ᗘ࢚ࢥ࣮ᇦࡋ࡚ほᐹࡉࢀࡓࠋࡇࡢᮇ㛫⬇⬊ࡣᏊᐑෆࢆ ⛣ືࡋ≉ 㹼 ᪥࡛ࡣࡑࡢ⛣ືᛶࡣάⓎ࡛࠶ࡗࡓࠋ㹼 ᪥ࡢ⬇⬊ࡣࢃ ࡎࡢ༸ᙧࢆ࿊ࡋ ᪥㸦sPP㸧௨㝆ࡣḟ➨୕ゅᙧࡽつ๎࡞ᙧ ≧࡛᥎⛣ࡋ㹼 ᪥⬇⬊ࡢᗏഃ ศࡢ ࡢ㡿ᇦ⬇Ꮚ㸦㹼PP㸧ࡀ☜ㄆ ࡉࢀࡓࠋ ᪥௨㝆ࡣ⬇⬊ࡢᏊᐑෆ࡛ࡢ⛣ືࡣほᐹࡉࢀ࡞ࡗࡓࠋ༸ᚋ 㹼 ᪥ࡢ⬇⬊ᚄࡣ⣙ PP ࡛࠶ࡾࡑࡢᮇ㛫୰ࡁ࡞ኚࡣほᐹࡉࢀ࡞ࡗ ࡓࠋ㔜㍛㤿ࡢ⬇⬊ࡢᡂ㛗᭤⥺ࡣ㹑Ꮠ≧࣮࢝ࣈࢆ♧ࡋࡓࠋ⬇⬊ᚄቑຍࡀ ࡍࡿ㓄ᚋ ᪥㹼 ᪥࠾ࡅࡿ⬇⬊ࡢࡁࡉࡣ 㹼PP ࡛ࡢ㤿✀ࡼࡾ ࡁ࠸ഴྥࡀほᐹࡉࢀࡇࡢᕪࡣ㤿ࡢ✀㢮ࡼࡿᏊᐑᙧ≧ࡢ┦㐪㉳ᅉࡍࡿࡇ ࡀ᥎ ࡉࢀࡓࠋ㔜㍛㤿ࡢᐃᮇⓗ࡞ዷፎデ᩿ࢆ⾜࠺ᙜࡓࡾ⬇⬊ࡢⓎ⫱⤒㐣 క࠺≉ᚩࢆᢕᥱࡋࡓୖ࡛ዷፎデ᩿ࢆࡍࡿࡇࡀ㔜せ࡛࠶ࡿࠋ㔜㍛㤿ࡢ⌮ⓗ࡞ ዷፎデ᩿ࡢᮇᅇᩘࡣึᅇࡣ⫾ዷፎࡢῶ⫾ฎ⨨ࡀྍ⬟࡞ ᪥๓ᚋ ᅇ ┠ࡣ⬇Ṛ⁛⋡ࡀపୗࡋ⬇Ꮚᚰᢿࡀ☜ㄆ࡛ࡁࡿ ᪥๓ᚋࡢ ᅇ⪃࠼ࡽࢀࡓࠋࡲ ࡓࡇࡢࡇࡼࡗ࡚ṇᖖ࡞⬇⬊ࡢⓎ⫱Ꮚᐑෆ⭷ᄞ⬊㸦ࢩࢫࢺ㸧ࡢ㢮㚷 ู⫾ዷፎࡸ᪩ᮇ⬇Ṛ⁛ࡢデ᩿ࢆⓗ☜⾜࠺ࡇࡀ࡛ࡁ㝈ࡽࢀࡓ㓄ᮇ㛫 ⓗ☜࡞㓄ࡀྍ⬟࡞ࡾ㔜㍛㤿ࡢ⦾Ṫຠ⋡ྥୖ⤖ࡧࡘࡃࡇࡀ᥎ᐹࡉࢀ ࡓࠋ
67
