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キャビネット 大阪大学大学院薬学研究科分子生物学分野

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AD ∨ ERTI SEI EN T FEAT∪ RE

■ 憾 撒器 撤 V蹴

Des pi t e pl oneer ng r es ear c h by many J apanes e

bl ol og s t s ′ t he app c at on of t hi s exper t s e has pr oc eeded s l ovν

y But c ha∩ge l s c onn ng qui c kl y NI B( ) ヽ ′ vas es t ab s hed l n Apr i 1 2005 by t he

」apanes e gover nment t o n‖ c r uc l al c l aps i n t he pat h f r o∩ ∩

d s c over y t o dr ug devel opm ent A

uni que i ns t t ut e′ NI B10 c ar r es out bas l c s c i enc e ai med at devel opl ng s har ed t ec hnol o91es at

t s l abor at ot t es i n t he Sa t o Lf e Sc l enc e Par k′ s t andar di z es and s har es bi ol o91c al r es our c es t hr ou9hout 」apan, and f u∩ ds ext er nal r es ear c h i n a s i m l ar f as hl on t o t he Nat onal l ns t t ut es of Hea t hl nt he US″ t ′s t he onl y p ac e ke t i n J apan′ s ays Kol c hl Yaman s hl ′ d r ec t or gener al of NI BI O

The J apanes e gov・r nl ment has r ec ogni z ed NI B Oゝ s pec a m s s o∩ i n s ever al ways l n 2008′ NI B O was awar ded t wo c ovet ed′ Super Spec i a Cons or t ur ∩

des 9nat ons f or t he devel opment of c ut t i ng―edge medl c al c ar e――t 1/ 17o of onl y 24 t bat 1/ er e appr oved nat on1/ 1/ de NI B10 has a s o t aken a l eader s hl p pos t o∩ │∩t he J apanes e gover nme∩ t t Know edge C us t er nt i aJ ve― a nve year pr aec t t o s t i mul at e c ooper at on bet 1/ / een r es ear c h

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l ns t t ut es ′ unl ver s t es and i ndus t r y i n bi omedi c al

s c enc es N B O ma nt a ns a hos t of , o nt r es ear c h

pr qec t s w t t h phar m ac euJ c a m anuち

c t ur er s i n nel ds r an9i n9 f r onn t oxl c ogenom c s and bl omar ker expl or at on t o anl r r al l mode s and vac c i ne devel opment ・1/ Ve meet r egul ar yヽ ぃ/ t h c or ∩pani es t o as k l r Nl hat t hey need f r or r us / s ayS hman s h

Next ‐

gener at i on i nf ec t i ous di s eas e

vac c i ne i nnovat i on pr oj ec t

l l N/ hen l s t ar t ed at N BO′

t ew peop e w er e

l nt er es t ed i ∩vac c l ne devel opment l r nmu∩ ol o9y pr ogr es s ed′ but manuf ac t ur er s ar e t oo s r r a‖ t o do muc h R&D/ s ays hman s hi ′ a vi r o o9 s t Wt h

dec ades of exper enc e s t udyi ng her pes and

ot her v r us es

Fo‖ oヽ″i n9 panl c s c aus ed by t he SARS c or ona―

v r us ′ t he H5Nl avi an nu and mOs t r ec ent y t he

Hl Nl pandem c nu′ 9。ver nr r ent s and l ndus t r y have s t ar t ed payi ng at t ent on

Yaman s hi l eads a Super Spec al Cons or t un l n 、Ⅳhi c h unl ver s t es , nat i onal r es ear c h c ent r es ′ phar mac eui c a c or r pan es and hos pt t a s ai m t o c r eat e next gener aj on vac c i nes f or Hl v ma at t a′

i n¶uenz a a∩ d ot her l nf ec t i ous di s eas es

The c ons or t unns 9oal i s t o i r npr ove vac c l nes by s t udyl ∩ g neヽ♂ν vec t or s t hat ヽ/ vi ‖ enabl e s l n91e

vac c l nes t o c onvey i r r n un t y t o mu t i pl e l nf ec ― t ous d s eas es NI B( ) has s i gni nc ant c apab t l es i n t he genet c r ec or ∩ bi nat on t ec h∩ ol o9y needed t o c r eat e t hes e vec t or s ′ ぃ/ hl c h l l 17 make vac c i nat on pr ogr ams eas l er and c heaper

The l ―ons or t um s a s o devel opi ng nas a‖

y

der ma‖ y and or a‖ y adn¬ n s t r at ed vac c i nes as s at t r and mor e c onven ent at er nat ves t o nj ec t ons ″ Tb s t ype of i mmunl z at i on i s c l os er t o our

nat ur a i m m unt ゾ

s ayS hma∩l s hl

The c ons or j um w deve op ne1/ Nl adl uva∩t S t o enha∩c e t he er ec t of vac c i nes and a‖ oヽ″ t he us e of s ma‖ er dos es Unc er t al nt y about hovν adj uvant s wor k has been an obs t ac e t o t her l mpl ement at on′ but J apanes e s c l ent s t s have l ed t he anal ys s of t o‖ l ke r ec ept or s and ot her

r e at ed c om ponent s of t he i m m une s ys t em 仏

new 9ener at o∩

of ef ec i ve adj uvant s w c om e

f r om J apan′

Says hm ans h w t h c onndenc e

D evel opm ent of a novel dr ug t oxi c i t y

t es t i ng s ys t enl us i ng i nduc ed

pl ur i pot ent s t em c e‖

s

Phar mac eut c al c on pani es ar e l nc r eas l ngl y us i ng embr yon c s t em( E5) c e denved c e‖ neages t or ′ η l l t r ot es t n9 of dr u9s But ES c e‖ s ar e i n s hor t s uppl y

nduc ed p unpot ent s t em l PS) Ce S′

n r s t

c r eat ed i ∩ J apan l n 2006′ of f er an a t er nat ve i PS c e s ar e r r ade by r epr o9r ar r mi ng s omat c c e s t o an er ∩br yo l ke s t at e Sc l ent s t s c an do t h s l Al t h anyone′ s c e‖s ′ o=、r i ∩g an i nnn t e s our c e of f r es h c e s ヽⅣ t h denned genet c bac k9r ounds

Res ear c h 9` oups byt hedoz ens haveem br ac ed

l PS c e‖ t ec hnol ogy Bef or e t hey c an be us ed i n dr u9 devel opment ′ hoヽ´′ever ′ t hey need t o be s t andar di z ed and qua t y c ont r o‖ ed i ∩

a m anner

t hat f ac t at es c ni c al s t udl es by phar mac eut i c al c or ∩pani es apan l s l eadl ng t he exann nat on of I PS c e s / s ayS N BI Oゝ H r oyuk Mi z uguc h′

″ but l mos t unl ver s i t y gr oups s t op at t he r es ear c h l eve r l 1711z u9uc hi l eads a Super Spec l al Cons or t um t o es t ab s h a dr ug t oxi c t y t es t ng s ys t em bas ed on i PS c e‖ s Suc h a s ys t er ∩l 17‖ r r た c ont r over J al

σ

The uni que r ol e of NI B10 i n J apan. NI B10 c or ∩bl nes ext ens l ve c o‖ abor aJ on wl h bas l c r es ear c h,

vauabeboogc a r es our c es andpr aec t f undngt os uppO t t t hephar m ac euJ c a ndus t r y

Adver t s 「・r r et ai ns s ol e r es pons i b i t y Tor c ont e∩ t

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