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IL-6 ノックアウトマウスを提供してくださった M. Kopf 氏 (Max-Planck-Instituteof Immunobiology, Germany) 、 Type I collagen Cre マウスを提供してくださった G. Karsenty 氏 (Baylor College of Medicine, Houston, TX) STAT3 floxlflox マウスを提供してくださった審良静男氏(Osaka University, Japan) 、 C57BL/6 OT2 TCR トランスジェニックマウスを提供してくださった W. R. Heath 氏 (University of Melbourne, Australia) 、関節微小出血につき重要な議論をしてくださった Jordan 氏 (Cincinnati Children's Hospital, Cincinnati, OH) に深く感謝致します。
本研究の実験補佐に従事された優秀な技術補佐員の皆さん、池谷さん、林さん、 Deng さん、蒋 祷腎さん、奥山梓さん、熊井乃里子さん、秘書の増田涼子さん、 TCRTg-RAG2_,,-F759 マウス系統の 樹立に尽力された澤新一郎さん、西原三佳さん、 Jin さんに深く感謝致します。
本研究の実施および論文執筆にあたって暖かく貴重なご指導をくださった平野俊夫教授、村上正 晃准教授、助教の上村大輔先生、ポスドクの澤幸久先生、熱海徹先生をはじめ、生命機能研究科 免疫発生学研究室、医学系研究科腫瘍病理学教室の皆様、理研 RCAI サイトカイン制御研究グ ループの皆様に深謝致します。
また本研究において、実際の実験および解析に携わり共同で研究を進めてきた助教の小椋英樹先 生、大学院生の浅野省吾さん、金本宵さん、原田誠也さん、有馬康伸さんに心より感謝致します。
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業績一覧
(1) 学術雑誌
ｷImmunity 2008 29(4) pp. 628 ‑636.
#Hideki Ogural, #Masaaki Murakami1, Yuko Okuyamal, Mineko Tsuruoka, Chika Kitabayashi, Minoru Kanamoto, Mika Nishihara, Yoichiro Iwakura, Toshio Hirano.
Interleukin‑I 7 Promotes Autoimmunity by Trigge1ｷing a Positive‑Feedback via Interleukin‑6 Induction.
ｷInt Immunol. 2010 Feb;22(2):129 ・ 39.
Takayuki Nakagawa, Mineko Tsuruoka, Hideki Ogura, Yuko Okuyama, Yasunobu Arima, Toshio Hirano, Masaaki Murakami.
IL‑6 positively regulates Foxp3+CD8+ T cells in vivo.
• The Journal of Experimental Medicine. 2011 Jan 17;208(1): 103‑14.
Masaaki Murakami*, Yuko Okuyama*, Hideki Ogura*, Shogo Asano, Yasunobu Arima, Mineko Tsuruoka, Masaya Harada, Minoru Kanamoto, Yukihisa Bawa, Yoichiro Iwakura, Kiyoshi Takatsu, Daisuke Kamimura, Toshio Hirano (*equal contribution)
Local microbleeding facilitates IL螂6·and IL-17—dependent arthritis in the absence of tissue antigen recognition by activated T cells.
(2) 国内雑誌
・奥山祐子，村上正晃. Th17 細胞の分化とサイトカインシグナル． 臨床免疫• アレルギー科（化 学評論社）， 48(4) : 347ｷ353,2007
MINOPHAGEN MEDICAL REVIEW (MINOPHAGEN PHARMACEUTICAL CO.LTD.),52(3):24ｷ26,MAY 2007Yuko Okuyama.CD4+ 記憶 T 細胞生存維持の分子機構 ·FOX03a リ
ン酸化の重要性
(3) 国内学会
ｷHideki Ogura, Yuko Okuyama, Minoru Kanamoto, Masaaki Murakami, Toshio Hirano Antigen independent induction of a CD4+ T cell—dependent arthritis.
The 37th Annual Meeting of the Japanese Society for Immunology. Work shop 2‑BｷW19ｷ8‑0/P.
2007.Tokyo, Japan
ｷMasaaki Murakami, Hideki Ogura, Yuko Okuyama, Minoru Kanamoto,, Yoichiro Iwakura, Toshio Hirano.
IL‑17 derived from homeostatic proliferating memory/activated CD4+ Tcells develops arthritis in F759 mice.
The 37th Annual Meeting of the Japanese Society for Immunology. Symposium S9‑3. 2007.Tokyo, Japan
ｷHideki Ogura, Masaaki Murakami, Yuko Okuvama, Mineko Tsuruoka, Chika Kitabayashi, Minoru Kanamoto, Mika Nishihara, Yoichiro Iwakura, Toshio Hirano.
IL‑6 as a down stream target of ILｷ17 developed an autoimmune arthritis.
The 38th Ann叫 Meeting of the Japanese Society for Immunology. Work shop 2ｷGｷW29ｷ2ｷ 〇/P.2008.Kyoto,Ja pan.
ｷMasaaki Murakami, Hideki Ogura, Yuko Okuyama, Mineko Tsuruoka , Mika Nishihara, Yoichiro Iwakura, Toshio Hirano.
An ILｷ17‑triggerd positive feedback loop of IL‑6 signaling in autoimmune diseases.
The 38th Annual Meeting of the Japanese Society for Immunology. Symposium S8ｷ5. 2008.Kyoto,J a pan.
ｷMasaaki Murakami , Hideki Ogura, Yuko Okuvama, Mineko Tsuruoka , Mika Nishihara, Yoichiro Iwakura, Toshio Hirano.
An IL・ 17·triggerd positive feedback loop of IL‑6 signaling in autoimmune diseases.
The 39th Annual Meeting of the Japanese Society for Immunology. Symposium S8‑5. 2009. 〇saka,Japan.
ｷHideki Ogura, Yuko Okuyama, Minoru Kanamoto, Yasunobu Arima, Mineko Tsuruoka, , Shogo Asano, Daisuke Kamimura, Yoichiro Iwakura, Masaaki Murakami, Toshia Hirano. Specific antigen recognitions by activated CD4+T cells are not necessary for the development of a MHC class IIｷassociated arthritis.
The 39th Annual Meeting of the Japanese Society for Immunology. Work shop 2‑H‑W36ｷ8ｷ0/P.2009.0saka,Japan.
ｷShogo Asano , Yuko Okuyama, Yasunobu Arima , Mineko Tsuruoka, Masaya Harada , Yoichiro Iwakura, Hideki Ogura, Masaaki Murakami, Toshio Hirano.
Activation of "IL‑6 amplify loop" at ankle joint is important for the development of F759‑Arthritis.
The 39th Annual Meeting of the Japanese Society for Immunology. Work shop