䠏᫬㛫䠏᫬㛫

䠏᫬㛫

ᘏ䜉ゼၥᅇᩘ㻌㻌㻌䠎㻌 ᅇ ྜィ㻌䠒᫬㛫

ᡂᯝ䛸䛧䛶Ⓨ⾲䛧䛯ㄽᩥ

1䠊Mitsuteru Asai, Yoshiya Miyagawa, Nur’Ain Idris, Abdul Muhari, Fumihiko Imamura䛂Coupled tsunami simulation based on a 2D shallow water quation based finite difference method and 3D incompressible smoothed particle dhydrodynamics䛃, Journal of Earthquake and Tsunami䠈(doi: 10.1142/S1793431116400194) 䠈2016 ᖺ 12 ᭶䠄ᰝㄞ᭷䠅, ᅜ㝿䝆䝱䞊䝘䝹䠈IF=0.33

2䠊Masaharu Isshiki, Mitsuteru Asai, Shimon Eguchi, Hideyuki O-tani䛂3D tsunami run-up simulation and visualization using particle method with GIS-based geography model 䛃 , Journal of Earthquake and Tsunami 䠈 ᰝ ㄞ ᭷ 䠈 (doi:

10.1142/S1793431116400200) 䠈2016 ᖺ 12 ᭶䠄ᰝㄞ᭷䠅䠈ᅜ㝿䝆䝱䞊䝘䝹䠈IF=0.33 Ꮫ⾡ㄽᩥ㻌 ྜィ䠄2䠅⦅㻌

≉チ䞉ᐇ⏝᪂᱌䞉䛭䛾௚䛾⏘ᴗ㈈⏘ᶒ㻌㻌㻌䛺䛧

㻌 ྜィ㻌䠄0䠅㻌 ௳䛾䛖䛱䚸㻌 A ฟ㢪㻌ィ䠄㻌㻌䠅௳㻌 B ྲྀᚓ ィ䠄㻌㻌䠅௳

+0'

ิߨŢƅŬƃŘſ

ᖹᡂ䠎䠔ᖺᗘᮾ໭኱Ꮫ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤඹྠ◊✲ሗ࿌᭩

◊ ✲ ㄢ㢟 ྡ

ᮾ᪥ᮏ኱㟈⅏ᚋ䛾ఫ⎔ቃ䛾ኚ໬䛻䜘䜛䜰䝺䝹䜼䞊⑌ᝈ䛾Ⓨ⑕䞉㻌 ቑᝏ䛻㛵䛩䜛␿Ꮫㄪᰝ䛸┿⳦䞉䝎䝙䜰䝺䝹䝀䞁䛻ᑐ䛩䜛⎔ቃᩚഛ㻌

௓ධ᪉ἲ䛾☜❧

◊✲ㄢ㢟 ղ

◊ ✲ ௦ ⾲ ⪅ 㔮ᮌ⃝ᑦᐇ

ᡤᒓᶵ㛵➼䞉⫋ྡ ᅜ❧⑓㝔ᶵᵓᇸ⋢⑓㝔㻌 ࿧྾ჾෆ⛉㻌 ་ᖌ

◊✲⤌⧊䠄⤌⧊ᵓᡂဨ䛾Ặྡ䞉ᡤᒓᶵ㛵ྡ䠅

۔㔮ᮌ⃝ᑦᐇ䠄ᅜ❧⑓㝔ᶵᵓᇸ⋢⑓㝔䠅䚸䚽ᰩᒣ㐍୍(⅏ᐖ◊)䚸Ώ㎶㯞⾰Ꮚ䠄ᅜ❧་⸆ရ㣗ရ⾨⏕◊✲ᡤ䚸⎔ቃ ᚤ⏕≀Ꮫ䠅䚸ᢲ᪉ᬛஓᏊ䠄ᅜ❧⑓㝔ᶵᵓᇸ⋢⑓㝔䠅䚸㙊⏣ὒ୍䠄ᒾᡭ኱Ꮫ㎰Ꮫ㒊ඹྠ⋇་Ꮫ⛉䞉⎔ቃᚤ⏕≀Ꮫ䠅䚸

▮ෆ㻌 ຾䠄▼ᕳ᪥ᮏ㉥༑Ꮠ⑓㝔䠅

ᮇ㻌㛫 ᖹᡂ 28 ᖺ 10 ᭶ 1 ᪥䡚ᖹᡂ 29 ᖺ 3 ᭶ 31 ᪥ ⤒㻌㈝ 850,000 ෇ 䛆◊✲䛾ᴫせ䛇

䛆⫼ᬒ䛇⏦ㄳ⪅䜙䛿䚸2014 ᖺ 6 ᭶䛛䜙 2016 ᖺ 7 ᭶䜎䛷䛻ᐑᇛ┴▼ᕳᕷ䛾ᛂᛴ௬タఫᏯ䜎䛯䛿୍⯡ఫᏯ䛻ᅾఫ䛩䜛 15 ṓ௨ୖ䛾ఫẸ䜢ᑐ㇟䛸䛧䛶࿧྾ჾᑓ㛛་䛻䜘䜛䜰䝺䝹䜼䞊࿧྾ჾ⑌ᝈ䛻㛵䛩䜛㞟ᅋ᳨デ䜢⾜䛳䛯䚹௬タఫᏯ ධᒃṔ䛾䛒䜛ఫẸ䛻ᑐ䛩䜛Ẽ⟶ᨭႍᜥ䛾᭷⑕⋡䚸᭷⑓⋡䛿 2014 ᖺ 344 ྡཷ᳨䚸ᖹᆒᖺ㱋 61.3±15.8 ṓ䚸⏨ᛶ 37.2%䚸᭷⑕⋡ 21.8%䚸᭷⑓⋡ 22.4%䚸2015 ᖺ 224 ྡཷ᳨䚸ᖹᆒᖺ㱋 61.6±14.2 ṓ䚸⏨ᛶ 35.0%䚸᭷⑕⋡ 19.6%䚸

᭷⑓⋡ 24.6%䚸2016 ᖺ 284 ྡཷ᳨䚸ᖹᆒᖺ㱋 65.2±13.7 ṓ䚸⏨ᛶ 38.6%䚸᭷⑕⋡ 22.5%䚸᭷⑓⋡ 23.9%䛸 3 ᖺ㛫䛷䛿኱䛝䛺ኚ໬䛿䛺䛟䚸ᮏ㑥䛷ሗ࿌䛥䜜䛶䛔䜛ᡂேႍᜥ䛾᭷⑕⋡䛸ẚ㍑䛧䛶⣙ 2 ಸ௨ୖ䛷䛒䜛䛣䛸䛜᫂䜙䛛䛸䛺䛳䛯䚹䜎䛯⾑Ύ୰䛾䝎䝙≉␗ⓗ IgE ᢠయ䚸䜰䝇䝨䝹䜼䝹䝇≉␗ⓗ IgE ᢠయ䜢 ᐃ䛩䜛䛸ႍᜥ⑕౛䛻䛚䛔䛶䝎䝙≉␗

ⓗ IgE ᢠయ㝧ᛶ౛䛜᭷ព䛻ከ䛔䛣䛸䛜᫂䜙䛛䛸䛺䛳䛯䚹ᛂᛴ௬タఫᏯ䛷䛿┿⳦䛾␗ᖖቑṪ䛜▱䜙䜜䛶䛔䜛䛜䛭䜜䛻䜘䜚䝎䝙䛜ቑຍ䛧䝎䝙䜰䝺䝹䝀䞁䠄Der 1䠅ឤస䛜ቑᙉ䛧䛶䛔䜛ྍ⬟ᛶ䛜⪃䛘䜙䜜䜛䚹ᮏ⏦ㄳ◊✲䛷䛿䚸ᙜヱ᳨デ஦

ᴗ䛻䛚䛔䛶䚸2016 ᖺ䛻᪋⾜䛧䛯ᐑᇛ┴▼ᕳᕷ䛾ᛂᛴ௬タఫᏯ䜎䛯䛿୍⯡ఫᏯ䛻ᅾఫ䛩䜛 15 ṓ௨ୖ䛾ఫẸ䜢ᑐ

㇟䛸䛧䛯㞟ᅋ᳨デཷ᳨⪅䜢ᑐ㇟䛸䛧ఫᒃ⎔ቃ୰䛾┿⳦ྀㄪᰝ䛸䝎䝙ᢠཎ㔞 ᐃ䜢⾜䛔䚸㜵䝎䝙䝅䞊䝒䜢౑⏝䛧⎔

ቃᩚഛᣦᑟ䜢⾜䛔䚸⎔ቃᩚഛᣦᑟ๓ᚋ䛾䝎䝙ᢠཎ㔞䛾᥎⛣䛸⮫ᗋ⤒㐣䜢㏣㊧䛧䛯䚹

䛆᪉ἲ䛇2016 ᖺ䛻᪋⾜䛧䛯ᐑᇛ┴▼ᕳᕷ䛾ᛂᛴ௬タఫᏯ䜎䛯䛿୍⯡ఫᏯ䛻ᅾఫ䛩䜛 15 ṓ௨ୖ䛾ఫẸ䜢ᑐ㇟䛸䛧䛯㞟ᅋ᳨デཷ᳨⪅䛾ෆ䚸2016 ᖺ 10 ᭶䛻ఫᒃ⎔ቃ୰䛾䝎䝙ᢠཎ㔞䚸┿⳦䝁䝻䝙䞊ᩘ䜢 ᐃ䛧䛯 91 ⑕౛䜢ᑐ㇟䛸䛧䛯䚹Der 1 㔞䛿ᐷල䛻ᑐ䛧䛶䝔䜺䝎䞊䝮䜢⏝䛔䛶᳨య䜢᥇ྲྀ䛧䚸㧗ឤᗘ⺯ග ELISA ἲ䜢⏝䛔䛶༢఩㠃✚ᙜ䛯䜚ᐷල

௜╔䝎䝙ᢠཎ㔞䜢ᐃ㔞䛧䛯䚹┿⳦䝁䝻䝙䞊ᩘ䛿䝔䜺䝎䞊䝮䛷᥇ྲྀ䛧䛯ᐷල௜╔⳦䜢ᐮኳᖹᯈᇵᆅ䛷ᇵ㣴ᚋ䚸ᾋ㐟

┿⳦ᩘ䜎䛯䛿༢఩ᙜ䛯䜚䛾ⴠୗ┿⳦ᩘ䜢⟬ฟ䛧䛯䚹⾑Ύ୰䛾⥲ IgE ್䚸䝁䝘䝠䝵䜴䝠䝎䝙䚸䝲䜿䝠䝵䜴䝠䝎䝙䚸䜰䝹䝨䝹䜼䝹䝇≉␗ⓗ IgE ᢠయ౯䛿䜰䝷䝇䝍䝑䝖 3g Allergy䠄CLEIA ἲ䠗SIEMENS ♫䠅䛷 ᐃ䛧䛯䚹Der 1 㔞䛾ᑐ↷䛸䛧䛶 NHO ┦ᶍཎ⑓㝔䛻㏻㝔Ṕ䛾䛒䜛ᡂேႍᜥᝈ⪅ 116 ྡ䜢ᑐ㇟䛸䛧䛶 2009-2012 ᖺ 9-10 ᭶䛻 ᐃ䛧䛯 Der 1 㔞䛾ᖹ ᆒ್䜢౑⏝䛧䛯䚹

䛆⤖ᯝ䛇Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䜢 ᐃ䛧䛯⑕౛ᩘ䛿 91 ౛䛷ᖹᆒᖺ㱋 65.7±13.6 ṓ䚸⏨ᛶ 35.2%䛷⌧௬タఫᏯධ ᒃ⪅ 30 ྡ䚸௬タఫᏯ䛛䜙䛾㌿ฟ⪅ 59 ྡ䚸௬タఫᏯእධᒃ⪅ 2 ྡ䛷䛒䛳䛯䚹௬タఫᏯධᒃṔ䛾䛒䜛 89 ྡ䛷䛿ႍ

ᜥ䛾᭷⑕⋡ 22 ྡ/89 ྡ䠄24.7%)䚸᭷⑓⋡䠄⫵Ẽ⭘䞉⫵Ẽ⭘+ႍᜥ䜢㝖䛟䠅18 ྡ/89 ྡ(20.2%)䛷䛒䛳䛯䚹䛭䛾୰䛷⌧௬ タධᒃ䛷䛿᭷⑕⋡ 10 ྡ/30 ྡ䠄33.3%)䚸᭷⑓⋡ 9 ྡ/30 ྡ䠄30%)䚸௬タ㌿ฟ⪅䛷䛿᭷⑕⋡ 12 ྡ/59 ྡ䠄20.3%䠅䚸

᭷⑓⋡ 9 ྡ/59 ྡ(15.3%)䛸᭷ពᕪ䛿䛺䛔䜒䛾䛾௬タ㌿ฟ⪅䛷䛿᭷⑕⋡䚸᭷⑓⋡䛸䜒䛻ᑡ䛺䛔ഴྥ䛜䛒䛳䛯䚹2016 ᖺ 10 ᭶䛻 ᐃ䛧䛯 log ᐷල Der 1 㔞䛿 2009-2012 ᖺ 9-10 ᭶䛻 ᐃ䛧䛯┦ᶍཎ⑓㝔䛻㏻㝔Ṕ䛾䛒䜛ᡂேႍᜥᝈ

⪅䛸ẚ㍑䛩䜛䛸௬タධᒃṔ䛒䜚䠄N=89䠅 vs ⚄ዉᕝ┴ႍᜥᝈ⪅䠄N=116 䠅䠙2.480±1.021䠄ᖹᆒ 302.0 ng/m ² 䠅 vs 1.560±0.933 䠄ᖹᆒ 36.3 ng/m ² 䠅䚸p<0.01 䛸᭷ព䛻௬タධᒃṔ䛾䛒䜛ఫẸ䛾ᐷල䛷㧗್䛷䛒䛳䛯䚹䜎䛯௬タධᒃṔ 䛒䜚䛾ఫẸ䜢⌧௬タ䠄ධᒃ୰䠅䛸䠄௬タ䠅㌿ฟᚋ䛷ẚ㍑䛩䜛䛸⌧௬タ vs ㌿ฟ䠙2.675±1.116䠄ᖹᆒ 473.2 ng/m ² 䠅vs

2.381±0.964䠄ᖹᆒ 240.4 ng/m ² 䠅䛸⌧௬タ䛷㧗್䛷䛒䜛ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹ECRHS

㉁ၥ⚊䛷ႍᜥ䛒䜚䛿ႍᜥ䛺䛧䛸ẚ㍑䛧䛶 log ᐷල Der 1 㔞䛿䛭䜜䛮䜜 2.630±0.782䠄ᖹᆒ 426.6 ng/m ² 䠅䚸2.431±1.088

䠄ᖹᆒ 269.8 ng/m ² 䠅䛸ႍᜥ䛒䜚䛷ᐷල Der 1 㔞䛜ከ䛔ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹ྠᵝ䛻་

ᖌ䛾デ᩿䛷ႍᜥ䛒䜚䚸ႍᜥ䛺䛧䛾 log ᐷල Der 1 㔞䛿䛭䜜䛮䜜 2.722±0.936䠄ᖹᆒ 527.2 ng/m ² 䠅䚸2.446±1.059䠄ᖹᆒ

279.3 ng/m ² 䠅䛷䛒䜚ႍᜥ䛒䜚䛷ᐷල Der 1 㔞䛜ከ䛔ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹

௬タఫᏯධᒃṔ䛾䛒䜛ఫẸ 89 ྡ䛾⾑Ύ⥲ IgE ್䚸䝁䝘䝠䝵䜴䝠䝎䝙䚸䝲䜿䝠䝵䜴䝠䝎䝙䚸䜰䝹䝨䝹䜼䝹䝇≉␗ⓗ IgE ᢠయ౯䛸ᐷල Der 1 㔞䛿䛔䛪䜜䜒᭷ព䛺┦㛵䜢ㄆ䜑䛺䛛䛳䛯䚹⌧௬タఫᏯᅾఫ䚸௬タ㌿ฟ䛾 2 ⩌㛫䛻䛚䛔䛶䜒᭷

ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹䜎䛯⌧௬タఫᏯᅾఫ䚸௬タఫᏯ䛛䜙㌿ฟ䛧䚸୍⯡ఫᏯ䜎䛯䛿᚟⯆ఫᏯ䛻ᅾఫ䛾 3 ⩌䛷

2016.6-7 ᭶䚸2017.3 ᭶䛾⾑Ύ⥲ IgE ್䚸䝁䝘䝠䝵䜴䝠䝎䝙䚸䝲䜿䝠䝵䜴䝠䝎䝙䚸䜰䝹䝨䝹䜼䝹䝇≉␗ⓗ IgE ᢠయ౯䜢ẚ

㍑䛧䛯䛜᭷ព䛺ኚ໬䛿ㄆ䜑䜙䜜䛺䛛䛳䛯䚹IgE㻌 ᢠయ౯Ӎ0.35 䜢㝧ᛶ䠄䝇䝁䜰䠍௨ୖ䠅䚸IgE㻌 ᢠయ౯=0.10-0.34 䜢␲㝧 ᛶ䛸䛩䜛䛸䚸䝁䝘䝠䝵䜴䝠䝎䝙㝧ᛶ⋡䠄IgE㻌 ᢠయ౯Ӎ0.35䠅䛿ႍᜥ䞉ႍᜥ␲䛔䠄⫵Ẽ⭘ྜేႍᜥ䜢㝖እ䠅䠖㠀ႍᜥ䠙 14.2%䠖30.0%䚸䝲䜿䝠䝵䜴䝠䝎䝙䛷䛿ႍᜥ䞉ႍᜥ␲䛔䠖㠀ႍᜥ䠙9.5%䠖30.0%䚸␲㝧ᛶ䜒ྵ䜑䛯䝁䝘䝠䝵䜴䝠䝎䝙㝧ᛶ⋡

䠄IgE㻌 ᢠయ౯Ӎ0.10䠅䛿ႍᜥ䞉ႍᜥ␲䛔䠄⫵Ẽ⭘ྜేႍᜥ䜢㝖እ䠅䠖㠀ႍᜥ䠙42.9%䠖48.9%䚸䝲䜿䝠䝵䜴䝠䝎䝙䛷䛿ႍ

ᜥ䞉ႍᜥ␲䛔䠖㠀ႍᜥ䠙33.3%䠖40.0%䛸௒ᅇ䛾⑕౛䛷䛿ႍᜥ䞉ႍᜥ␲䛔䛷㧗⋡䛷䛿䛺䛛䛳䛯䛜䚸ᚤᙅ㝧ᛶ౛䜢ྵ䜑䜛䛸ႍᜥ䞉㠀ႍᜥ䛸䜒䛻䝎䝙䜰䝺䝹䝀䞁㝧ᛶ⋡䛜㧗್䛷䛒䜛䛣䛸䛜᫂䜙䛛䛸䛺䛳䛯䚹

2016.6-7 ᭶䚸2017.3 ᭶䛻⫵ᶵ⬟᳨ᰝ䜢᪋⾜䛧䛯ఫẸ䛿 12 ྡ䛷ෆヂ䛿⌧௬タᅾఫ⪅ 4 ྡ䚸᚟⯆ఫᏯᅾఫ⪅ 6

ྡ䚸୍⯡ఫᏯ䛜 2 ྡ䛷䛒䛳䛯䚹2016.6-7 ᭶䛾%FEV1 䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 100.0±16.4䠗 90.5±20.4䠗113.0±2.6 䛸᭷ពᕪ䛿䛺䛟 2017.3 ᭶䛷䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 105.4±16.3䠗91.1±25.1䠗

108.5±0.3 䛸ኚ໬䛿ㄆ䜑䜙䜜䛺䛛䛳䛯䚹2016.6-7 ᭶䛾%V50 䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 96.9±47.9䠗

62.2±33.9䠗106.9±11.7䚸2017.3 ᭶䛷䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 103.1±40.2䠗77.6±36.4䠗107.1±15.5 䛸

᭷ពᕪ䛿ㄆ䜑䛺䛔䛜䚸᚟⯆ఫᏯ䛷䛿ⱝᖸୖ᪼䛩䜛ഴྥ䜢ㄆ䜑䛯䚹䜎䛯䠂FEV1䚸䠂V50 䛸ᐷල Der 1 㔞䛻䛿᭷ព䛺┦㛵䜢ㄆ䜑䛺䛛䛳䛯䚹

┿⳦䛾䝁䝻䝙䞊ᩘ䛿 1000CFU/m ³ 䜢㉸䛘䜛䛸䜹䝡ởᰁ䛜䛒䜛䛸ุ᩿䛥䜜䜛䛜䚸௬タఫᏯධᒃṔ䛾䛒䜛 89 ྡ䛾ෆ䚸 73 ྡ䠄73.0%䠅䛾⑕౛䛜 1000CFU/m ³ 䜢㉸䛘䛶䛚䜚┿⳦ởᰁ䛜᫂䜙䛛䛸䛺䛳䛯䚹log ┿⳦䝁䝻䝙䞊ᩘ䛿⌧௬タ䠗᚟⯆

ఫᏯ䛷䛿 3.55±1.22䠄ᖹᆒ 3548.1 CFU/m ³ 䠅vs 3.05±1.79䠄ᖹᆒ 1122.0 CFU/m ³ 䠅䛸⌧௬タ䛷┿⳦䝁䝻䝙䞊ᩘ䛜ከ䛔ഴ

ྥ䛿ㄆ䜑䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹2017.2 ᭶䛻 2016.10 ᭶ ᐃ䛾 Der 1 㔞䛾⤖ᯝ䜢㒑㏦䛷㏦௜

䛧䚸ᕼᮃ⪅ 26 ྡ䛻ᑐ䛧 2017.3 ᭶䛻㜵䝎䝙䝅䞊䝒䜢ᥦ౪䛧⎔ቃᩚഛ䝏䜵䝑䜽䝸䝇䝖䜢⏝䛔䛶㞟ᅋ⎔ቃᩚഛᣦᑟ䜢⾜

䛔䚸䛥䜙䛻ಶேᣦᑟ䜢⾜䛳䛯䚹ᣦᑟᚋ䛾ᐷල Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䛾ㄪᰝ䜢⾜䛔䝃䞁䝥䝸䞁䜾䛜⤊஢䛧䛯䚹⎔ቃ

ᩚഛᣦᑟᚋ䛾 Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䛾⤖ᯝ䜢㋃䜎䛘䛶䚸⎔ቃᩚഛ௓ධຠᯝ䜢ᇶ♏䞉⮫ᗋ㠃䛛䜙᳨ド䛩䜛ணᐃ䛷䛒䜛䚹

䛆⪃ᐹ䛇䜰䝺䝹䜼䞊ឤస䛿㧗㱋䛻䛺䜛䛻䛴䜜䛶ῶᑡ䛩䜛䛣䛸䛜▱䜙䜜䛶䛔䜛䛜䚸ᮏ◊✲䛷䛿㧗㱋⪅䛻䛚䛔䛶䜒≉䛻ᚤ ᙅ㝧ᛶ䜢ྵ䜑䜛䛸䜰䝺䝹䜼䞊ឤస⋡䛜㧗䛔䛣䛸䛛䜙䚸䜰䝺䝹䜼䞊ឤస䛜⏕䛨䛻䛟䛔ᖺ௦䛻䛚䛔䛶䜒ఫ⎔ቃኚ໬䛻䜘䜛䜰䝺䝹䝀䞁᭚㟢䛜ᙳ㡪䛩䜛䛸⪃䛘䜙䜜䜛䚹

䛆⤖ㄽ䛇ᐑᇛ┴▼ᕳᕷ䛾ᛂᛴ௬タఫᏯ䛾䜏䛺䜙䛪௬タఫᏯ㌿ฟᚋ䛻䛚䛔䛶䜒㧗⃰ᗘ䛾䝎䝙ᢠཎ᭚㟢䚸┿⳦ởᰁ䛜

☜ㄆ䛥䜜䛯䚹䜎䛯ᛂᛴ௬タఫᏯධᒃṔ䛾䛒䜛ఫẸ䛷䛿ႍᜥ䛾᭷⑕⋡䚸᭷⑓⋡䛜ᮏ㑥䛻䛚䛡䜛㐣ཤ䛾ሗ࿌䛸ẚ㍑䛧䛶㧗್䛷䛒䜛䛣䛸䛜᫂䜙䛛䛸䛺䛳䛯䚹ᮏ◊✲䛾ᑐ㇟䛿ᖹᆒᖺ㱋 65.7 ṓ䛷䛒䜛䛣䛸䛛䜙䚸㧗㱋⪅䛻䛚䛔䛶䜒ఫ⎔ቃኚ໬

䛻䜘䜚䜰䝺䝹䝀䞁ឤస䛜ቑᙉ䛩䜛䛣䛸䛜♧၀䛥䜜䛯䚹䝎䝙ᢠཎ䚸┿⳦ྀ䛻ᑐ䛩䜛⎔ቃᩚഛᣦᑟ䜢᪋⾜䛩䜛䛣䛸䛷ᐷල 䛾ᢠཎ㔞䛜ῶᑡ䛧䚸ႍᜥ䛾᭷⑕⋡䚸᭷⑓⋡䛜ῶᑡ䛩䜛䛣䛸䛜ᮇᚅ䛥䜜䜛䚹

䛆◊✲䛾ලయⓗ䛺ᡂᯝ䞉Ἴཬຠᯝ䛇

ᐑᇛ┴▼ᕳᕷ䛷䛾ᛂᛴ௬タఫᏯ䞉௬タఫᏯ㌿ฟᚋ䛾䛔䛪䜜䛻䛚䛔䛶䜒㧗⃰ᗘ䛾䝎䝙ᢠཎ᭚㟢䚸┿⳦ởᰁ䛜☜ㄆ䛥䜜䚸ႍᜥ䛾᭷⑕⋡䞉᭷⑓⋡ቑຍ䛸㛵㐃䛩䜛䛣䛸䛜⪃䛘䜙䜜䛯䚹㟈⅏ᚋ䛾ఫ⎔ቃኚ໬䛻䜘䜚䝎䝙䚸┿⳦䜰䝺䝹䝀䞁䛜 ቑຍ䛧䚸䜰䝺䝹䜼䞊ឤస䜢ቑᙉ䛩䜛ྍ⬟ᛶ䛜♧၀䛥䜜䜛䚹⎔ቃᩚഛᣦᑟ䛻䜘䜚䝎䝙䚸┿⳦䜰䝺䝹䝀䞁䛜ῶᑡ䛩䜛䛣䛸䛻䜘䜚䚸䜰䝺䝹䜼䞊⑌ᝈ䛾Ⓨ⑕䞉ቑᝏ䜢ᢚไ䛩䜛䛣䛸䛜ᮇᚅ䛥䜜䜛䚹

ᮏ◊✲䛿㟈⅏ᚋ䛾ఫ⎔ቃኚ໬䛻䜘䜛䜰䝺䝹䜼䞊⑌ᝈ䛾Ⓨ⑕䞉ቑᝏ䜢ᢚไ䛩䜛䛯䜑䛾ᣦ㔪䜢☜❧䛩䜛䛣䛸䛻䜘䜚䚸ᡃ

䛜ᅜ䛾⅏ᐖᚋ䛾䜰䝺䝹䜼䞊⑌ᝈ䛾⟶⌮䛻㈉⊩䛩䜛ྍ⬟ᛶ䛜䛒䜛䚹

䛆ᅗ⾲䛇

䠍䞉⛅䛾ᐷල Der1 㔞䠄⚄ዉᕝ┴䛸ẚ㍑䠅㻌䠎䞉⛅䛾ᐷල Der1 㔞䛾⌧௬タධᒃ䚸௬タ㌿ฟ䚸௬タእู䛾ẚ㍑

⅏ᐖ◊ゼၥ᪥ ౑⏝䛧䛯᪋タ䞉タഛ䞉Ꮫ⾡㈨ᩱ䞉

䡿䢚䡬䡼䢉䢚䡬䡹➼ ౑⏝᫬㛫䞉ᖹᡂ 28 ᖺ 10 ᭶ 28 ᪥(2 ྡ) ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤ 2 ᫬㛫

ᘏ䜉ゼၥᅇᩘ㻌㻌㻌 1㻌 ᅇ ྜィ㻌 2 ᫬㛫

ᡂᯝ䛸䛧䛶Ⓨ⾲䛧䛯ㄽᩥ

㛵㐃ㄽᩥ䛾䜏

Tsurikisawa N, Saito A, Oshikata C, Yasueda H, Akiyama K. Effective allergen avoidance for reducing exposure to house dust mite allergens and improving disease management in adult atopic asthmatics. J. Asthma. 2016;8:843-853.ᰝ ㄞ䛒䜚, ᅜ㝿, IF1.854

Oshikata C, Watanabe M, Saito A, Yasueda H, Akiyama K, Kamata Y, Tsurikisawa N. Allergic bronchopulmonary mycosis caused by Penicillium luteum. Med Mycol Case Rep 2017;15:9-11. ᰝㄞ䛒䜚, ᅜ㝿

㔮ᮌ⃝ᑦᐇ䚸ᢲ᪉ᬛஓᏊ䚸㰻⸨᫂⨾䚹䜰䝺䝹䜼䞊⑌ᝈ䛾䛩䜉䛶䚹䜰䝺䝹䜼䞊⑌ᝈ䚸᪻⹸䜰䝺䝹䜼䞊䚸䛂䝎䝙䛃䚹᪥ᮏ

་ᖌ఍㞧ㄅ㻌 2016;14 ᕳ䞉≉ูྕ䠄1䠅:S297-298.ᰝㄞ䛺䛧䚸౫㢗ཎ✏

ᢲ᪉ᬛஓᏊ䚸㰻⸨᫂⨾䚸Ώ㎶㯞⾰Ꮚ䚸㔮㔮ᮌ⃝ᑦᐇ䚹䜰䝺䝹䜼䞊⑌ᝈ䛾ண㜵㻌 ᐊෆᢠཎ䛸ᑐ⟇㻌 ෆ⛉ 2016;118:1093-1096. ᰝㄞ䛺䛧䚸౫㢗ཎ✏

Ꮫ⾡ㄽᩥ㻌 ྜィ䠄0䠅⦅㻌

≉チ䞉ᐇ⏝᪂᱌䞉䛭䛾௚䛾⏘ᴗ㈈⏘ᶒ 䛺䛧

㻌 ྜィ㻌䠄0䠅㻌 ௳䛾䛖䛱䚸㻌 A ฟ㢪㻌ィ䠄㻌㻌䠅௳㻌 B ྲྀᚓ ィ䠄㻌㻌䠅௳

ᖹᡂ䠎䠔ᖺᗘᮾ໭኱Ꮫ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤඹྠ◊✲ሗ࿌᭩

◊ ✲ ㄢ㢟 ྡ

๪ 㒔 ᚰ ᪂ ᐟ 䛾 ᣦ ᐃ 㑊㞴 ᡤ ㏆㞄 ⏫ ఍ 䞉 Ꮫ ᰯ 䞉⾜ ᨻ ➼ 䛸䛾㐃 ᦠ 䛷㻌

㐍䜑䜛⅏ᐖᑐ⟇䠖㻌⿕⅏᫬䛾་⒪䞉ಖ೺䞉⚟♴యไᨭ᥼䝅䝇䝔䝮䛾

ドキュメント内東北大学災害科学国際研究所活動報告書 2016年度（4.62MB） (ページ 81-85)

䠏᫬㛫 䠏᫬㛫

䠏᫬㛫

ᘏ䜉ゼၥᅇᩘ㻌 㻌 㻌 䠎㻌 ᅇ ྜィ㻌 䠒᫬㛫

ᡂᯝ䛸䛧䛶Ⓨ⾲䛧䛯ㄽᩥ

2䠊Masaharu Isshiki, Mitsuteru Asai, Shimon Eguchi, Hideyuki O-tani䛂3D tsunami run-up simulation and visualization using particle method with GIS-based geography model 䛃 , Journal of Earthquake and Tsunami 䠈 ᰝ ㄞ ᭷ 䠈 (doi:

10.1142/S1793431116400200) 䠈2016 ᖺ 12 ᭶䠄ᰝㄞ᭷䠅䠈ᅜ㝿䝆䝱䞊䝘䝹䠈IF=0.33 Ꮫ⾡ㄽᩥ㻌 ྜィ䠄2䠅⦅㻌

≉チ䞉ᐇ⏝᪂᱌䞉䛭䛾௚䛾⏘ᴗ㈈⏘ᶒ㻌 㻌 㻌 䛺䛧

㻌 ྜィ㻌 䠄0䠅㻌 ௳䛾䛖䛱䚸㻌 A ฟ㢪㻌 ィ䠄㻌 㻌 䠅௳㻌 B ྲྀᚓ ィ䠄㻌 㻌 䠅௳

+0'

ิߨŢƅŬƃŘſ

ᖹᡂ䠎䠔ᖺᗘᮾ໭኱Ꮫ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤඹྠ◊✲ሗ࿌᭩

◊ ✲ ㄢ 㢟 ྡ

ᮾ᪥ᮏ኱㟈⅏ᚋ䛾ఫ⎔ቃ䛾ኚ໬䛻䜘䜛䜰䝺䝹䜼䞊⑌ᝈ䛾Ⓨ⑕䞉㻌 ቑᝏ䛻㛵䛩䜛␿Ꮫㄪᰝ䛸┿⳦䞉䝎䝙䜰䝺䝹䝀䞁䛻ᑐ䛩䜛⎔ቃᩚഛ㻌

௓ධ᪉ἲ䛾☜❧

◊✲ㄢ㢟 ղ

◊ ✲ ௦ ⾲ ⪅ 㔮ᮌ⃝ᑦᐇ

ᡤᒓᶵ㛵➼䞉⫋ྡ ᅜ❧⑓㝔ᶵᵓᇸ⋢⑓㝔㻌 ࿧྾ჾෆ⛉㻌 ་ᖌ

◊✲⤌⧊䠄⤌⧊ᵓᡂဨ䛾Ặྡ䞉ᡤᒓᶵ㛵ྡ䠅

▮ෆ㻌 ຾䠄▼ᕳ᪥ᮏ㉥༑Ꮠ⑓㝔䠅

ᮇ㻌 㛫 ᖹᡂ 28 ᖺ 10 ᭶ 1 ᪥䡚ᖹᡂ 29 ᖺ 3 ᭶ 31 ᪥ ⤒㻌 ㈝ 850,000 ෇ 䛆◊✲䛾ᴫせ䛇

ᴗ䛻䛚䛔䛶䚸2016 ᖺ䛻᪋⾜䛧䛯ᐑᇛ┴▼ᕳᕷ䛾ᛂᛴ௬タఫᏯ䜎䛯䛿୍⯡ఫᏯ䛻ᅾఫ䛩䜛 15 ṓ௨ୖ䛾ఫẸ䜢ᑐ

㇟䛸䛧䛯㞟ᅋ᳨デཷ᳨⪅䜢ᑐ㇟䛸䛧ఫᒃ⎔ቃ୰䛾┿⳦ྀㄪᰝ䛸䝎䝙ᢠཎ㔞 ᐃ䜢⾜䛔䚸㜵䝎䝙䝅䞊䝒䜢౑⏝䛧⎔

ቃᩚഛᣦᑟ䜢⾜䛔䚸⎔ቃᩚഛᣦᑟ๓ᚋ䛾䝎䝙ᢠཎ㔞䛾᥎⛣䛸⮫ᗋ⤒㐣䜢㏣㊧䛧䛯䚹

௜╔䝎䝙ᢠཎ㔞䜢ᐃ㔞䛧䛯䚹┿⳦䝁䝻䝙䞊ᩘ䛿䝔䜺䝎䞊䝮䛷᥇ྲྀ䛧䛯ᐷල௜╔⳦䜢ᐮኳᖹᯈᇵᆅ䛷ᇵ㣴ᚋ䚸ᾋ㐟

䛆⤖ᯝ䛇Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䜢 ᐃ䛧䛯⑕౛ᩘ䛿 91 ౛䛷ᖹᆒᖺ㱋 65.7±13.6 ṓ䚸⏨ᛶ 35.2%䛷⌧௬タఫᏯධ ᒃ⪅ 30 ྡ䚸௬タఫᏯ䛛䜙䛾㌿ฟ⪅ 59 ྡ䚸௬タఫᏯእධᒃ⪅ 2 ྡ䛷䛒䛳䛯䚹௬タఫᏯධᒃṔ䛾䛒䜛 89 ྡ䛷䛿ႍ

ᜥ䛾᭷⑕⋡ 22 ྡ/89 ྡ䠄24.7%)䚸᭷⑓⋡䠄⫵Ẽ⭘䞉⫵Ẽ⭘+ႍᜥ䜢㝖䛟䠅18 ྡ/89 ྡ(20.2%)䛷䛒䛳䛯䚹䛭䛾୰䛷⌧௬ タධᒃ䛷䛿᭷⑕⋡ 10 ྡ/30 ྡ䠄33.3%)䚸᭷⑓⋡ 9 ྡ/30 ྡ䠄30%)䚸௬タ㌿ฟ⪅䛷䛿᭷⑕⋡ 12 ྡ/59 ྡ䠄20.3%䠅䚸

᭷⑓⋡ 9 ྡ/59 ྡ(15.3%)䛸᭷ពᕪ䛿䛺䛔䜒䛾䛾௬タ㌿ฟ⪅䛷䛿᭷⑕⋡䚸᭷⑓⋡䛸䜒䛻ᑡ䛺䛔ഴྥ䛜䛒䛳䛯䚹2016 ᖺ 10 ᭶䛻 ᐃ䛧䛯 log ᐷල Der 1 㔞䛿 2009-2012 ᖺ 9-10 ᭶䛻 ᐃ䛧䛯┦ᶍཎ⑓㝔䛻㏻㝔Ṕ䛾䛒䜛ᡂேႍᜥᝈ

2.381±0.964䠄ᖹᆒ 240.4 ng/m 2 䠅䛸⌧௬タ䛷㧗್䛷䛒䜛ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹ECRHS

㉁ၥ⚊䛷ႍᜥ䛒䜚䛿ႍᜥ䛺䛧䛸ẚ㍑䛧䛶 log ᐷල Der 1 㔞䛿䛭䜜䛮䜜 2.630±0.782䠄ᖹᆒ 426.6 ng/m 2 䠅䚸2.431±1.088

䠄ᖹᆒ 269.8 ng/m 2 䠅䛸ႍᜥ䛒䜚䛷ᐷල Der 1 㔞䛜ከ䛔ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹ྠᵝ䛻་

ᖌ䛾デ᩿䛷ႍᜥ䛒䜚䚸ႍᜥ䛺䛧䛾 log ᐷල Der 1 㔞䛿䛭䜜䛮䜜 2.722±0.936䠄ᖹᆒ 527.2 ng/m 2 䠅䚸2.446±1.059䠄ᖹᆒ

279.3 ng/m 2 䠅䛷䛒䜚ႍᜥ䛒䜚䛷ᐷල Der 1 㔞䛜ከ䛔ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹

ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹䜎䛯⌧௬タఫᏯᅾఫ䚸௬タఫᏯ䛛䜙㌿ฟ䛧䚸୍⯡ఫᏯ䜎䛯䛿᚟⯆ఫᏯ䛻ᅾఫ䛾 3 ⩌䛷

2016.6-7 ᭶䚸2017.3 ᭶䛾⾑Ύ⥲ IgE ್䚸䝁䝘䝠䝵䜴䝠䝎䝙䚸䝲䜿䝠䝵䜴䝠䝎䝙䚸䜰䝹䝨䝹䜼䝹䝇≉␗ⓗ IgE ᢠయ౯䜢ẚ

䠄IgE㻌 ᢠయ౯Ӎ0.10䠅䛿ႍᜥ䞉ႍᜥ␲䛔䠄⫵Ẽ⭘ྜేႍᜥ䜢㝖እ䠅䠖㠀ႍᜥ䠙42.9%䠖48.9%䚸䝲䜿䝠䝵䜴䝠䝎䝙䛷䛿ႍ

ᜥ䞉ႍᜥ␲䛔䠖㠀ႍᜥ䠙33.3%䠖40.0%䛸௒ᅇ䛾⑕౛䛷䛿ႍᜥ䞉ႍᜥ␲䛔䛷㧗⋡䛷䛿䛺䛛䛳䛯䛜䚸ᚤᙅ㝧ᛶ౛䜢ྵ䜑 䜛䛸ႍᜥ䞉㠀ႍᜥ䛸䜒䛻䝎䝙䜰䝺䝹䝀䞁㝧ᛶ⋡䛜㧗್䛷䛒䜛䛣䛸䛜᫂䜙䛛䛸䛺䛳䛯䚹

2016.6-7 ᭶䚸2017.3 ᭶䛻⫵ᶵ⬟᳨ᰝ䜢᪋⾜䛧䛯ఫẸ䛿 12 ྡ䛷ෆヂ䛿⌧௬タᅾఫ⪅ 4 ྡ䚸᚟⯆ఫᏯᅾఫ⪅ 6

ྡ䚸୍⯡ఫᏯ䛜 2 ྡ䛷䛒䛳䛯䚹2016.6-7 ᭶䛾%FEV1 䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 100.0±16.4䠗 90.5±20.4䠗113.0±2.6 䛸᭷ពᕪ䛿䛺䛟 2017.3 ᭶䛷䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 105.4±16.3䠗91.1±25.1䠗

108.5±0.3 䛸ኚ໬䛿ㄆ䜑䜙䜜䛺䛛䛳䛯䚹2016.6-7 ᭶䛾%V50 䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 96.9±47.9䠗

62.2±33.9䠗106.9±11.7䚸2017.3 ᭶䛷䛿⌧௬タ䠗᚟⯆ఫᏯ䠗୍⯡ఫᏯ䛷䛭䜜䛮䜜 103.1±40.2䠗77.6±36.4䠗107.1±15.5 䛸

᭷ពᕪ䛿ㄆ䜑䛺䛔䛜䚸᚟⯆ఫᏯ䛷䛿ⱝᖸୖ᪼䛩䜛ഴྥ䜢ㄆ䜑䛯䚹 䜎䛯䠂FEV1䚸䠂V50 䛸ᐷල Der 1 㔞䛻䛿᭷ព䛺┦㛵䜢ㄆ䜑䛺䛛䛳䛯䚹

┿⳦䛾䝁䝻䝙䞊ᩘ䛿 1000CFU/m 3 䜢㉸䛘䜛䛸䜹䝡ởᰁ䛜䛒䜛䛸ุ᩿䛥䜜䜛䛜䚸௬タఫᏯධᒃṔ䛾䛒䜛 89 ྡ䛾ෆ䚸 73 ྡ䠄73.0%䠅䛾⑕౛䛜 1000CFU/m 3 䜢㉸䛘䛶䛚䜚┿⳦ởᰁ䛜᫂䜙䛛䛸䛺䛳䛯䚹log ┿⳦䝁䝻䝙䞊ᩘ䛿⌧௬タ䠗᚟⯆

ఫᏯ䛷䛿 3.55±1.22䠄ᖹᆒ 3548.1 CFU/m 3 䠅vs 3.05±1.79䠄ᖹᆒ 1122.0 CFU/m 3 䠅䛸⌧௬タ䛷┿⳦䝁䝻䝙䞊ᩘ䛜ከ䛔ഴ

ྥ䛿ㄆ䜑䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹2017.2 ᭶䛻 2016.10 ᭶ ᐃ䛾 Der 1 㔞䛾⤖ᯝ䜢㒑㏦䛷㏦௜

䛧䚸ᕼᮃ⪅ 26 ྡ䛻ᑐ䛧 2017.3 ᭶䛻㜵䝎䝙䝅䞊䝒䜢ᥦ౪䛧⎔ቃᩚഛ䝏䜵䝑䜽䝸䝇䝖䜢⏝䛔䛶㞟ᅋ⎔ቃᩚഛᣦᑟ䜢⾜

䛔䚸䛥䜙䛻ಶேᣦᑟ䜢⾜䛳䛯䚹ᣦᑟᚋ䛾ᐷල Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䛾ㄪᰝ䜢⾜䛔䝃䞁䝥䝸䞁䜾䛜⤊஢䛧䛯䚹⎔ቃ

ᩚഛᣦᑟᚋ䛾 Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䛾⤖ᯝ䜢㋃䜎䛘䛶䚸⎔ቃᩚഛ௓ධຠᯝ䜢ᇶ♏䞉⮫ᗋ㠃䛛䜙᳨ド䛩䜛ணᐃ䛷 䛒䜛䚹

䛆⤖ㄽ䛇ᐑᇛ┴▼ᕳᕷ䛾ᛂᛴ௬タఫᏯ䛾䜏䛺䜙䛪௬タఫᏯ㌿ฟᚋ䛻䛚䛔䛶䜒㧗⃰ᗘ䛾䝎䝙ᢠཎ᭚㟢䚸┿⳦ởᰁ䛜

䛻䜘䜚䜰䝺䝹䝀䞁ឤస䛜ቑᙉ䛩䜛䛣䛸䛜♧၀䛥䜜䛯䚹䝎䝙ᢠཎ䚸┿⳦ྀ䛻ᑐ䛩䜛⎔ቃᩚഛᣦᑟ䜢᪋⾜䛩䜛䛣䛸䛷ᐷල 䛾ᢠཎ㔞䛜ῶᑡ䛧䚸ႍᜥ䛾᭷⑕⋡䚸᭷⑓⋡䛜ῶᑡ䛩䜛䛣䛸䛜ᮇᚅ䛥䜜䜛䚹

䛆◊✲䛾ලయⓗ䛺ᡂᯝ䞉Ἴཬຠᯝ䛇

ᮏ◊✲䛿㟈⅏ᚋ䛾ఫ⎔ቃኚ໬䛻䜘䜛䜰䝺䝹䜼䞊⑌ᝈ䛾Ⓨ⑕䞉ቑᝏ䜢ᢚไ䛩䜛䛯䜑䛾ᣦ㔪䜢☜❧䛩䜛䛣䛸䛻䜘䜚䚸ᡃ

䛜ᅜ䛾⅏ᐖᚋ䛾䜰䝺䝹䜼䞊⑌ᝈ䛾⟶⌮䛻㈉⊩䛩䜛ྍ⬟ᛶ䛜䛒䜛䚹

䛆ᅗ⾲䛇

䠍䞉⛅䛾ᐷල Der1 㔞䠄⚄ዉᕝ┴䛸ẚ㍑䠅㻌 䠎䞉⛅䛾ᐷල Der1 㔞䛾⌧௬タධᒃ䚸௬タ㌿ฟ䚸௬タእู䛾ẚ㍑

⅏ᐖ◊ゼၥ᪥ ౑⏝䛧䛯᪋タ䞉タഛ䞉Ꮫ⾡㈨ᩱ䞉

䡿䢚䡬䡼䢉䢚䡬䡹➼ ౑⏝᫬㛫 䞉ᖹᡂ 28 ᖺ 10 ᭶ 28 ᪥(2 ྡ) ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤ 2 ᫬㛫

ᘏ䜉ゼၥᅇᩘ㻌 㻌 㻌 1㻌 ᅇ ྜィ㻌 2 ᫬㛫

ᡂᯝ䛸䛧䛶Ⓨ⾲䛧䛯ㄽᩥ

㛵㐃ㄽᩥ䛾䜏

Tsurikisawa N, Saito A, Oshikata C, Yasueda H, Akiyama K. Effective allergen avoidance for reducing exposure to house dust mite allergens and improving disease management in adult atopic asthmatics. J. Asthma. 2016;8:843-853.ᰝ ㄞ䛒䜚, ᅜ㝿, IF1.854

Oshikata C, Watanabe M, Saito A, Yasueda H, Akiyama K, Kamata Y, Tsurikisawa N. Allergic bronchopulmonary mycosis caused by Penicillium luteum. Med Mycol Case Rep 2017;15:9-11. ᰝㄞ䛒䜚, ᅜ㝿

㔮ᮌ⃝ᑦᐇ䚸ᢲ᪉ᬛஓᏊ䚸㰻⸨᫂⨾䚹䜰䝺䝹䜼䞊⑌ᝈ䛾䛩䜉䛶䚹䜰䝺䝹䜼䞊⑌ᝈ䚸᪻⹸䜰䝺䝹䜼䞊䚸䛂䝎䝙䛃䚹᪥ᮏ

་ᖌ఍㞧ㄅ㻌 2016;14 ᕳ䞉≉ูྕ䠄1䠅:S297-298.ᰝㄞ䛺䛧䚸౫㢗ཎ✏

ᢲ᪉ᬛஓᏊ䚸㰻⸨᫂⨾䚸Ώ㎶㯞⾰Ꮚ䚸㔮 㔮ᮌ⃝ᑦᐇ䚹䜰䝺䝹䜼䞊⑌ᝈ䛾ண㜵㻌 ᐊෆᢠཎ䛸ᑐ⟇㻌 ෆ⛉ 2016;118:1093-1096. ᰝㄞ䛺䛧䚸౫㢗ཎ✏

Ꮫ⾡ㄽᩥ㻌 ྜィ䠄0䠅⦅㻌

≉チ䞉ᐇ⏝᪂᱌䞉䛭䛾௚䛾⏘ᴗ㈈⏘ᶒ 䛺䛧

㻌 ྜィ㻌 䠄0䠅㻌 ௳䛾䛖䛱䚸㻌 A ฟ㢪㻌 ィ䠄㻌 㻌 䠅௳㻌 B ྲྀᚓ ィ䠄㻌 㻌 䠅௳

ᖹᡂ䠎䠔ᖺᗘᮾ໭኱Ꮫ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤඹྠ◊✲ሗ࿌᭩

◊ ✲ ㄢ 㢟 ྡ

๪ 㒔 ᚰ ᪂ ᐟ 䛾 ᣦ ᐃ 㑊 㞴 ᡤ ㏆ 㞄 ⏫ ఍ 䞉 Ꮫ ᰯ 䞉 ⾜ ᨻ ➼ 䛸 䛾 㐃 ᦠ 䛷㻌

㐍䜑䜛⅏ᐖᑐ⟇䠖㻌 ⿕⅏᫬䛾་⒪䞉ಖ೺䞉⚟♴యไᨭ᥼䝅䝇䝔䝮䛾

ᘏ䜉ゼၥᅇᩘ㻌㻌㻌䠎㻌 ᅇ ྜィ㻌䠒᫬㛫

≉チ䞉ᐇ⏝᪂᱌䞉䛭䛾௚䛾⏘ᴗ㈈⏘ᶒ㻌㻌㻌䛺䛧

㻌 ྜィ㻌䠄0䠅㻌 ௳䛾䛖䛱䚸㻌 A ฟ㢪㻌ィ䠄㻌㻌䠅௳㻌 B ྲྀᚓ ィ䠄㻌㻌䠅௳

◊ ✲ ㄢ㢟 ྡ

ᮇ㻌㛫 ᖹᡂ 28 ᖺ 10 ᭶ 1 ᪥䡚ᖹᡂ 29 ᖺ 3 ᭶ 31 ᪥ ⤒㻌㈝ 850,000 ෇ 䛆◊✲䛾ᴫせ䛇

2.381±0.964䠄ᖹᆒ 240.4 ng/m ² 䠅䛸⌧௬タ䛷㧗್䛷䛒䜛ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹ECRHS

㉁ၥ⚊䛷ႍᜥ䛒䜚䛿ႍᜥ䛺䛧䛸ẚ㍑䛧䛶 log ᐷල Der 1 㔞䛿䛭䜜䛮䜜 2.630±0.782䠄ᖹᆒ 426.6 ng/m ² 䠅䚸2.431±1.088

䠄ᖹᆒ 269.8 ng/m ² 䠅䛸ႍᜥ䛒䜚䛷ᐷල Der 1 㔞䛜ከ䛔ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹ྠᵝ䛻་

ᖌ䛾デ᩿䛷ႍᜥ䛒䜚䚸ႍᜥ䛺䛧䛾 log ᐷල Der 1 㔞䛿䛭䜜䛮䜜 2.722±0.936䠄ᖹᆒ 527.2 ng/m ² 䠅䚸2.446±1.059䠄ᖹᆒ

279.3 ng/m ² 䠅䛷䛒䜚ႍᜥ䛒䜚䛷ᐷල Der 1 㔞䛜ከ䛔ഴྥ䛿䛒䜛䜒䛾䛾⤫ィᏛⓗ᭷ពᕪ䛿ㄆ䜑䛺䛛䛳䛯䚹

ᜥ䞉ႍᜥ␲䛔䠖㠀ႍᜥ䠙33.3%䠖40.0%䛸௒ᅇ䛾⑕౛䛷䛿ႍᜥ䞉ႍᜥ␲䛔䛷㧗⋡䛷䛿䛺䛛䛳䛯䛜䚸ᚤᙅ㝧ᛶ౛䜢ྵ䜑䜛䛸ႍᜥ䞉㠀ႍᜥ䛸䜒䛻䝎䝙䜰䝺䝹䝀䞁㝧ᛶ⋡䛜㧗್䛷䛒䜛䛣䛸䛜᫂䜙䛛䛸䛺䛳䛯䚹

᭷ពᕪ䛿ㄆ䜑䛺䛔䛜䚸᚟⯆ఫᏯ䛷䛿ⱝᖸୖ᪼䛩䜛ഴྥ䜢ㄆ䜑䛯䚹䜎䛯䠂FEV1䚸䠂V50 䛸ᐷල Der 1 㔞䛻䛿᭷ព䛺┦㛵䜢ㄆ䜑䛺䛛䛳䛯䚹

┿⳦䛾䝁䝻䝙䞊ᩘ䛿 1000CFU/m ³ 䜢㉸䛘䜛䛸䜹䝡ởᰁ䛜䛒䜛䛸ุ᩿䛥䜜䜛䛜䚸௬タఫᏯධᒃṔ䛾䛒䜛 89 ྡ䛾ෆ䚸 73 ྡ䠄73.0%䠅䛾⑕౛䛜 1000CFU/m ³ 䜢㉸䛘䛶䛚䜚┿⳦ởᰁ䛜᫂䜙䛛䛸䛺䛳䛯䚹log ┿⳦䝁䝻䝙䞊ᩘ䛿⌧௬タ䠗᚟⯆

ఫᏯ䛷䛿 3.55±1.22䠄ᖹᆒ 3548.1 CFU/m ³ 䠅vs 3.05±1.79䠄ᖹᆒ 1122.0 CFU/m ³ 䠅䛸⌧௬タ䛷┿⳦䝁䝻䝙䞊ᩘ䛜ከ䛔ഴ

ᩚഛᣦᑟᚋ䛾 Der 1 㔞䚸┿⳦䝁䝻䝙䞊ᩘ䛾⤖ᯝ䜢㋃䜎䛘䛶䚸⎔ቃᩚഛ௓ධຠᯝ䜢ᇶ♏䞉⮫ᗋ㠃䛛䜙᳨ド䛩䜛ணᐃ䛷䛒䜛䚹

䠍䞉⛅䛾ᐷල Der1 㔞䠄⚄ዉᕝ┴䛸ẚ㍑䠅㻌䠎䞉⛅䛾ᐷල Der1 㔞䛾⌧௬タධᒃ䚸௬タ㌿ฟ䚸௬タእู䛾ẚ㍑

䡿䢚䡬䡼䢉䢚䡬䡹➼ ౑⏝᫬㛫䞉ᖹᡂ 28 ᖺ 10 ᭶ 28 ᪥(2 ྡ) ⅏ᐖ⛉Ꮫᅜ㝿◊✲ᡤ 2 ᫬㛫

ᘏ䜉ゼၥᅇᩘ㻌㻌㻌 1㻌 ᅇ ྜィ㻌 2 ᫬㛫

ᢲ᪉ᬛஓᏊ䚸㰻⸨᫂⨾䚸Ώ㎶㯞⾰Ꮚ䚸㔮㔮ᮌ⃝ᑦᐇ䚹䜰䝺䝹䜼䞊⑌ᝈ䛾ண㜵㻌 ᐊෆᢠཎ䛸ᑐ⟇㻌 ෆ⛉ 2016;118:1093-1096. ᰝㄞ䛺䛧䚸౫㢗ཎ✏

㻌 ྜィ㻌䠄0䠅㻌 ௳䛾䛖䛱䚸㻌 A ฟ㢪㻌ィ䠄㻌㻌䠅௳㻌 B ྲྀᚓ ィ䠄㻌㻌䠅௳

◊ ✲ ㄢ㢟 ྡ

๪ 㒔 ᚰ ᪂ ᐟ 䛾 ᣦ ᐃ 㑊㞴 ᡤ ㏆㞄 ⏫ ఍ 䞉 Ꮫ ᰯ 䞉⾜ ᨻ ➼ 䛸䛾㐃 ᦠ 䛷㻌

㐍䜑䜛⅏ᐖᑐ⟇䠖㻌⿕⅏᫬䛾་⒪䞉ಖ೺䞉⚟♴యไᨭ᥼䝅䝇䝔䝮䛾